A5058927067- Streptococcal Infections and Treatments
- Pneumonia and Respiratory Infections
- Antimicrobial Resistance in Staphylococcus
- Infective Endocarditis Diagnosis and Management
- COVID-19 epidemiological studies
- Bioinformatics and Genomic Networks
- Inflammasome and immune disorders
- Antifungal resistance and susceptibility
- Cardiac, Anesthesia and Surgical Outcomes
- Data-Driven Disease Surveillance
- Bacterial Infections and Vaccines
- Privacy, Security, and Data Protection
- Cell death mechanisms and regulation
- Plant Virus Research Studies
- Respiratory Support and Mechanisms
- Mental Health Research Topics
- Immune Response and Inflammation
- Hemodynamic Monitoring and Therapy
- Animal Virus Infections Studies
- Complex Network Analysis Techniques
- Oral microbiology and periodontitis research
- Probiotics and Fermented Foods
- Dermatology and Skin Diseases
- Metabolomics and Mass Spectrometry Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Houston Health and Human Services Department
2022-2024
The University of Texas Health Science Center at Houston
2019-2020
Columbia University
2015-2016
The University of Texas Health Science Center at San Antonio
2014-2015
Hospitalization of the elderly for invasive pneumococcal disease is frequently accompanied by occurrence an adverse cardiac event; these are primarily new or worsened heart failure and arrhythmia. Herein, we describe previously unrecognized microscopic lesions (microlesions) formed within myocardium mice, rhesus macaques, humans during bacteremic Streptococcus pneumoniae infection. In (IPD) severity correlated with levels serum troponin, a marker damage, development aberrant...
Staphylococcus aureus triggers inflammation through inflammasome activation and recruitment of neutrophils, responses that are critical for pathogen clearance but associated with substantial tissue damage. We postulated necroptosis, cell death mediated by the RIPK1/RIPK3/MLKL pathway, would function to limit pathological inflammation. In models skin infection or sepsis, Mlkl-/- mice had high bacterial loads, an inability interleukin-1b (IL-1b) production, excessive Similarly, treated RIPK1...
Skin is the most common site of Staphylococcus aureus infection. While these infections are self-limited, recurrent common. Keratinocytes and recruited immune cells participate in skin defense against We postulated that S. able to adapt milieu within human keratinocytes avoid keratinocyte-mediated clearance. From a collection isolated from chronically infected patients with atopic dermatitis, we noted 22% had an agr mutant-like phenotype. Using several models infection, demonstrate...
, a Gram-positive bacterium, and
Enterococcus faecalis is a significant cause of hospital-acquired bacteremia. Herein, the discovery reported that cardiac microlesions form during severe bacteremic E. infection in mice. The were identical appearance to those formed by Streptococcus pneumoniae invasive pneumococcal disease. However, does not encode virulence determinants implicated microlesion formation. Rather, disulfide bond forming protein A (DsbA) was found be required for Caenorhabditis elegans model and necessary...
During bacteremia Streptococcus pneumoniae can translocate across the vascular endothelium into myocardium and form discrete bacteria-filled microscopic lesions (microlesions) that are remarkable due to absence of infiltrating immune cells. Due their release cardiotoxic products, S. within microlesions thought contribute heart failure is frequently observed during fulminate invasive pneumococcal disease in adults. Herein demonstrated a protocol for experimental mouse infection leads...
Latent classification model is a class of statistical methods for identifying unobserved membership among the study samples using some observed data. In this study, we proposed latent that takes censored longitudinal binary outcome variable and uses its changing pattern over time to predict individuals' membership. Assuming time-dependent variables follow continuous-time Markov chain, method has two primary goals: (1) estimate distribution classes membership, (2) class-specific transition...
Abstract Objectives Pre-exposure prophylaxis (PrEP) is a key biomedical intervention for ending the HIV epidemic in United States, but its uptake impeded by systemic barriers, including fragmented workflows and ineffective data coordination. This study aims to design PrEPLinker, blockchain-based, client-centered platform enhance care address these challenges improving coordination enabling clients securely manage their identity PrEP-related data. Materials Methods Using Houston, Texas, as...
During bacteremia Streptococcus pneumoniae can translocate across the vascular endothelium into myocardium and form discrete bacteria-filled microscopic lesions (microlesions) that are remarkable due to absence of infiltrating immune cells. Due their release cardiotoxic products, S. within microlesions thought contribute heart failure is frequently observed during fulminate invasive pneumococcal disease in adults. Herein demonstrated a protocol for experimental mouse infection leads...
Abstract This study evaluates the scale-free network assumption commonly used in COVID-19 epidemiology, using empirical social data from SARS-CoV-2 Delta variant molecular local clusters Houston, Texas. We constructed genome-informed networks contact and co-residence data, tested them for power-law distributions that imply highly connected hubs, compared to alternative models (exponential, log-normal, with exponential cutoff, Weibull) suggest more evenly distributed connections. Although...
Abstract Background Viral genomes contain records of geographic movements and cross-scale transmission dynamics. However, the impact regional heterogeneity, particularly among rural urban centers, on viral spread epidemic trajectory has been less explored due to limited data availability. Intensive widespread efforts collect sequence SARS-CoV-2 samples have enabled development comparative genomic approaches reconstruct spatial history understand across different scales. Methods We proposed a...
A bstract The ongoing SARS-CoV-2 pandemic has highlighted the difficulty in integrating disparate data sources for epidemiologic surveillance. To address this challenge, we have created a graph database to integrate phylogenetic trees, associated metadata, and community surveillance phylodynamic inference. As an example use case, divided 22,713 samples into 5 groups, generated maximum likelihood inferred potential transmission network from forest of minimum spanning trees built on patristic...
Abstract Enterococcus faecalis is a significant cause of hospital-acquired bacteremia. Herein, the discovery reported that cardiac microlesions form during severe bacteremic E. infection in mice. The were identical appearance to those formed by Streptococcus pneumoniae invasive pneumococcal disease (IPD). However, does not encode virulence determinants implicated microlesion formation. Rather, disulfide bond forming protein DsbA was found be required for C. elegans model and necessary...