A5017043678- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Retinal and Optic Conditions
- Glaucoma and retinal disorders
- Retinal and Macular Surgery
- Retinal Development and Disorders
- Ocular Diseases and Behçet’s Syndrome
- Intraocular Surgery and Lenses
- Acute Ischemic Stroke Management
- Vascular Malformations Diagnosis and Treatment
- Cold Atom Physics and Bose-Einstein Condensates
- Ophthalmology and Visual Impairment Studies
- Connexins and lens biology
- Ocular Oncology and Treatments
- Advanced Fiber Laser Technologies
- Cerebral Venous Sinus Thrombosis
- Quantum optics and atomic interactions
- Quantum Information and Cryptography
- Laser-Matter Interactions and Applications
- Drug-Induced Ocular Toxicity
- Cerebrovascular and Carotid Artery Diseases
- Optical Coherence Tomography Applications
- Advanced Causal Inference Techniques
- Visual perception and processing mechanisms
- Peripheral Artery Disease Management
Doheny Eye Institute
2016-2025
University of California, Los Angeles
2016-2025
Cleveland Clinic
2023
UCLA Health
2019-2020
University of Miami
2005-2018
University of Wisconsin–Madison
2008-2017
Smith-Kettlewell Eye Research Institute
2017
University of Wisconsin Foundation
2008-2016
American Academy of Ophthalmology
2008-2012
University of Wisconsin System
2010
Error in Figure in: A Randomized Trial Comparing the Efficacy and Safety of Intravitreal Triamcinolone With Observation to Treat Vision Loss Associated Macular Edema Secondary Central Retinal Vein Occlusion: Standard Care vs Corticosteroid for Occlusion (SCORE) Study Report 5
To evaluate effects of intravitreal ranibizumab on diabetic retinopathy (DR) severity over time in 2 phase 3 clinical trials (RIDE, NCT00473382; RISE, NCT00473330) for macular edema.Participants with edema (n=759) were randomized to monthly sham, 0.3-mg ranibizumab, or 0.5-mg injections. Macular laser was available per protocol-specified criteria. Fundus photographs, taken at baseline and periodically, graded by a central reading center; examinations performed monthly. The main outcome...
Studies have established the efficacy and safety of aflibercept for treatment macular edema due to central retinal vein occlusion. Bevacizumab is used off-label treat this condition despite absence supporting data.To investigate whether bevacizumab noninferior secondary or hemiretinal occlusion.The SCORE2 randomized noninferiority clinical trial was conducted at 66 private practice academic centers in United States, included 362 patients with occlusion who were 1:1 receive bevacizumab. The...
To determine the rate of anatomical closure idiopathic macular holes undergoing vitreous surgery with respect to preoperative horizontal diameter as determined by optical coherence tomography (OCT) and correlate postoperative visual acuity, duration symptoms, late reopening initial hole OCT.Forty eyes 40 patients an were examined OCT before after surgery. All treated pars plana vitrectomy, peeling posterior cortical vitreous, dilute perfluoropropane or sulfur hexafluoride gas. Face-down...
Objective: To investigate the safety and efficacy of intravitreal triamcinolone acetonide as treatment for macular edemaassociatedwithcentralretinalveinocclusion(CRVO). Methods:We reviewed medical records 13 consecutive patients (13 eyes) with edema associated CRVO who were treated an injection (4 mg) at University Wisconsin Bascom Palmer Eye Institute.Each was delivered through pars plana using a 27-or 30-gauge needle.Main Outcome Measures: Change in Snellen visual acuity, clinical...
To assess the effects of intravitreal ranibizumab on diabetic retinopathy (DR) severity when administered for up to 3 years, evaluate effect delayed initiation therapy DR severity, and identify baseline patient characteristics associated with development proliferative (PDR).Exploratory analyses phase III, randomized, double-masked, sham-controlled multicenter clinical trials.Adults macular edema (DME) (N = 759), best-corrected visual acuity 20/40 20/320 Snellen equivalent, central foveal...
The purpose of this study was to evaluate the correlation between quantity intraretinal hyperreflective foci (HRF) in eye with intermediate AMD and progression late AMD.Volume optical coherence tomography (OCT) scans from 114 eyes patients were retrospectively reviewed. HRF assessed both qualitatively quantitatively. Five sequential en face slabs midretina thresholded isolate HRF. These five recombined, area measured whole 6 × 6-mm image (HRFTOT) within central 3-mm (HRF3mm) 5-mm (HRF5mm)...
Purpose To evaluate the correlation between choriocapillaris (CC) flow alterations around geographic atrophy (GA) and GA yearly growth rate (yGR) in patients with dry age-related macular degeneration (AMD). Methods We retrospectively reviewed analyzed spectral domain optical coherence tomography (SD-OCT) SD-OCT angiography images of consecutive acquired using Cirrus OCT at Doheny Eye Centers 2015 2017. All eligible had one 6 x mm OCTA scan during first visit (considered as baseline) two...
Aims To evaluate the choriocapillaris (CC) flow alterations around geographic atrophy (GA) in eyes with dry age-related macular degeneration. Methods Using a swept-source optical coherence tomography angiography (SS-OCTA) device, two volume 6×6 mm scans were acquired patients GA presenting between June and December 2017 at Doheny-UCLA Eye Centers. The area of was delineated on en face structural OCT fundus images. For each eye, OCTA slabs level CC from acquisitions averaged compensated for...
<h3>Importance</h3> Change in areas of incomplete retinal pigment epithelium (RPE) and outer atrophy (iRORA) within eyes with geographic (GA) might reflect similar changes among drusen but no GA. <h3>Objective</h3> To evaluate the potential association pegcetacoplan progression iRORA GA secondary to AMD. <h3>Design, Setting, Participants</h3> This post hoc analysis phase 2 multicenter, randomized, single-masked, sham-controlled FILLY trial intravitreal for 12 months took place from February...
To evaluate the effect of monthly intravitreal ranibizumab on hard exudate (HE) area and impact HE visual acuity (VA) outcomes in diabetic macular edema (DME) patients using data from 2 phase III clinical trials.Exploratory analyses III, randomized, double-masked, sham-controlled, multicenter trials.Adults with DME, baseline best-corrected VA 20/40 to 20/320 Snellen equivalent, central foveal thickness ≥275 μm.Between studies, 759 DME were randomized receive 0.3 or 0.5 mg (Lucentis;...
Purpose To evaluate the various patterns of subretinal fluid (SRF) in eyes with age-related macular degeneration (AMD) absence neovascularisation (MNV) and to assess long-term outcomes these eyes. Methods This retrospective study included only non-neovascular AMD associated SRF. Eyes evidence MNV were excluded. Spectral-domain optical coherence tomography (SD-OCT) was obtained at baseline follow-up, qualitative quantitative SD-OCT analysis drusen including drusenoid pigment epithelial...