A5051619670- 3D Printing in Biomedical Research
- Electrospun Nanofibers in Biomedical Applications
- Tissue Engineering and Regenerative Medicine
- Cellular Mechanics and Interactions
- Additive Manufacturing and 3D Printing Technologies
- Advanced Cellulose Research Studies
- Mechanical Circulatory Support Devices
- Optical Imaging and Spectroscopy Techniques
- Cardiac Structural Anomalies and Repair
- Platelet Disorders and Treatments
- Body Contouring and Surgery
- Dermatologic Treatments and Research
- Biomedical and Engineering Education
- Thermoregulation and physiological responses
- Antimicrobial agents and applications
- Fluid Dynamics and Turbulent Flows
- Planarian Biology and Electrostimulation
- Advanced Materials and Mechanics
- Heat Transfer Mechanisms
- Silk-based biomaterials and applications
- Cardiovascular and Diving-Related Complications
- Heat Transfer and Optimization
- Bone Tissue Engineering Materials
- Polydiacetylene-based materials and applications
- Antimicrobial Peptides and Activities
Zurich University of the Arts
2023
ETH Zurich
2014-2021
Wyss Center for Bio and Neuroengineering
2019
Polytechnic University of Turin
2014
Recent advances in biomaterials, thin film processing, and nanofabrication offer the opportunity to design electronics with novel unique capabilities, including high mechanical stability biodegradation, which are relevant medical implants, environmental sensors, wearable disposable devices. Combining reliable electrical performance deformation chemical degradation remains still challenging. This work reports temperature sensors whose material composition enables full biodegradation while...
Experimental evidences are reported on the potential of direct metal laser sintering (DMLS) in manufacturing flat and finned heat sinks with a remarkably enhanced convective transfer coefficient, taking advantage artificial roughness fully turbulent regime. To best our knowledge, this is first study where by DMLS investigated terms such thermal performances. On rough surfaces, we experience peak 73% for enhancement (63% average) compared to smooth surfaces. (single) performance found be 40%...
A powerful replica molding methodology to transfer on-demand functional topographies the surface of bacterial cellulose nanofiber textures is presented. With this method, termed guided assembly-based biolithography (GAB), a surface-structured polydimethylsiloxane (PDMS) mold introduced at gas-liquid interface an Acetobacter xylinum culture. Upon fermentation, generated nanofibers are assembled in three-dimensional network reproducing geometric shape imposed by mold. Additionally, GAB yields...
The micron-scale surface topography of implanted materials represents a complementary pathway, independent the material biochemical properties, regulating process biological recognition by cells which mediate inflammatory response to foreign bodies. Here we explore rational design modifications in micron range optimize comprised symmetrical array hexagonal pits interfering with focal adhesion establishment and maturation. When implemented on silicones hydrogels vitro, anti-adhesive...
Abstract Progressive antibiotic resistance is a serious condition adding to the challenges associated with skin wound treatment, and antibacterial dressings alternatives antibiotics are urgently needed. Cellulose‐based membranes increasingly considered as dressings, necessitating further functionalization steps. A bifunctional peptide, combining an antimicrobial peptide (AMP) cellulose binding (CBP), designed. AMPs affect bacteria via multiple modes of action, thereby reducing evolutionary...
Upon cardiac implantable electronic device (CIED) exchange, upgrade, or revision surgery patients are exposed to a considerable risk of adverse events. The presence firm fibrotic tissue endangers these procedures. Leads can be damaged in the attempt freeing them from tissue. Hematoma form as result capsulectomy, pocket debridement and leads dissection. Due increasing number CIED upgrade surgeries, incidence related complications is expected rise near future.The aim study was evaluate...
In this study, a medical device made of surface microstructured bacterial cellulose was produced using cellulose-producing acetic acid bacteria wild-type strains in combination with guided assembly-based biolithography. The aims at interfering the cell's focal adhesion establishment and maturation around implantable devices placed soft tissues by symmetrical array on its surface. A total 25 Komagataeibacter evaluated over three-step selection. first step, ability to produce suitable layer...
The generation of a confluent and functional endothelium at the luminal surface cardiovascular devices represents ideal solution to avoid contact between blood synthetic materials thus allowing long-term body integration implants. Due foreseen paucity source cells in patients, engineering strategies achieve full endothelialization, while minimizing amount endothelial required seed leading prompt coverage with an are necessary. A stable endothelialization is result interplay cells,...
Autologous epidermis grafts generated in vitro represent a promising option for the treatment of burn wounds. The procedure relies on sufficient number cells harvested from healthy tissue, which are then sparsely seeded target surface. time required to reconstitute fully confluent and mature monolayer limited availability cell seeds hinder broad clinical application this procedure. Here, novel engineering approach enhance expansion epithelial tissues is designed experimentally validated....
Abstract Bacterial colonization of drivelines represents a major adverse event in the implantation left ventricular assist devices (L-VADs) for treatment congestive heart failure. From external driveline interface and through skin breach, pathogens can ascend to pump pocket, endangering device function patient’s life. Surface Micro-Engineered Biosynthesized cellulose (BC) is an implantable biomaterial, which minimizes fibrotic tissue deposition promotes healthy regeneration. The topographic...