A5056738043- Wound Healing and Treatments
- Mesenchymal stem cell research
- Electrospun Nanofibers in Biomedical Applications
- Algal biology and biofuel production
- 3D Printing in Biomedical Research
- Tissue Engineering and Regenerative Medicine
- Planarian Biology and Electrostimulation
- Zebrafish Biomedical Research Applications
- Mitochondrial Function and Pathology
- Spaceflight effects on biology
- Angiogenesis and VEGF in Cancer
- Nanoplatforms for cancer theranostics
- Periodontal Regeneration and Treatments
- Erythropoietin and Anemia Treatment
- Nerve injury and regeneration
- Bone Metabolism and Diseases
- Reconstructive Surgery and Microvascular Techniques
- Alzheimer's disease research and treatments
- Aquatic Ecosystems and Phytoplankton Dynamics
- ATP Synthase and ATPases Research
- Lymphatic System and Diseases
- Pluripotent Stem Cells Research
- Diabetic Foot Ulcer Assessment and Management
- Micro and Nano Robotics
- Cardiac Ischemia and Reperfusion
Pontificia Universidad Católica de Chile
2015-2024
Technical University of Munich
2008-2022
Klinikum rechts der Isar
2008-2022
University of Chile
2003-2015
University of Tübingen
2012
University of Lübeck
2005-2009
München Klinik
2009
University Hospital Schleswig-Holstein
2005-2008
Milwaukee School of Engineering
2008
Universitäres Kinderwunschzentrum Lübeck
2007
Insufficient oxygen supply represents a relevant issue in several fields of human physiology and medicine. It has been suggested that the implantation photosynthetic cells can provide to tissues absence vascular supply. This approach demonstrated be successful vitro vivo models; however, no data is available about their safety patients. Here, an early phase-1 clinical trial (ClinicalTrials.gov identifier: NCT03960164, https://clinicaltrials.gov/ct2/show/NCT03960164) presented evaluate...
All engineered bioartificial structures developed for tissue regeneration require oxygen and nutrients to establish proper physiological functions. Aiming improve vascularization during dermal regeneration, we combined the use of a collagen scaffold defined human mesenchymal cell (MC) line. This line, termed V54/2, exhibits typical morphologic immunohistochemical characteristics MC. V54/2 cells seeded in were able survive, proliferate, secrete significant amounts vascular endothelial growth...
Smokers frequently suffer from impaired fracture healing often due to poor bone quality and stability. Cigarette smoking harms cells their homeostasis by increased formation of reactive oxygen species (ROS). The aim this study was investigate whether Quercetin, a naturally occurring antioxidant, can protect osteoblasts the toxic effects smoking. Human exposed cigarette smoke medium (CSM) rapidly produced ROS viability decreased concentration- time-dependently. Co-, pre- postincubation with...
Mesenchymal stem cells (MSCs) have been shown to improve tissue regeneration in several preclinical and clinical trials. These used combination with three-dimensional scaffolds as a promising approach the field of regenerative medicine. We compare behavior human adipose-derived MSCs (AdMSCs) on four different biomaterials that are awaiting or already received FDA approval determine suitable scaffold for delivering these dermal wounds increasing healing potential. AdMSCs were isolated,...
Abstract Mesenchymal stem cells (MSCs) are known to play a key role in tissue regeneration, while smoking cigarettes is described impair it. This work focuses on the effect cigarette smoke extract (CSE) has migration, differentiation and paracrine potential of human adipose derived MSCs (AdMSCs). To mimic native conditions vitro, AdMSCs were cultured either monolayer or three-dimensional pellet cultures. While constant exposure high concentrations CSE had lethal effects AdMSCs, lower...
Delayed wound healing and scar formation are among the most frequent complications after surgical interventions. Although biodegradable sutures present an excellent drug delivery opportunity, their primary function is tissue fixation. Mesenchymal stem cells (MSC) act as trophic mediators successful in activating biomaterials. Here were filled with adipose-derived mesenchymal (ASC) to provide a pro-regenerative environment at injured site. Results showed that filling, ASCs attach suture...
Many therapies using mesenchymal stem cells (MSC) rely on their ability to produce and release paracrine signals with chemotactic pro-angiogenic activity. These characteristics, however, are mostly studied under standard in vitro culture conditions. In contrast, various novel cell-based imply pre-seeding MSC into bio-artificial scaffolds. Here we describe human bone marrow-derived seeded Integra matrices, a common type of scaffold for dermal regeneration (SDR). We show measured the...