A5031060612- Textile materials and evaluations
- Advancements in Transdermal Drug Delivery
- Cellular Mechanics and Interactions
- Skin Protection and Aging
- Glaucoma and retinal disorders
- Wound Healing and Treatments
- Religious Freedom and Discrimination
- Theology and Canon Law Studies
- Bone fractures and treatments
- 3D Printing in Biomedical Research
- Engineering Technology and Methodologies
- Advanced Drug Delivery Systems
- Elasticity and Material Modeling
- Geotechnical and Geomechanical Engineering
- Drug Solubulity and Delivery Systems
- Tendon Structure and Treatment
- Ocular Diseases and Behçet’s Syndrome
- Laser Applications in Dentistry and Medicine
- Biochemical and Structural Characterization
- Bacterial Identification and Susceptibility Testing
- Retinal Diseases and Treatments
- Microfluidic and Bio-sensing Technologies
- Religion and Society Interactions
- Plant Surface Properties and Treatments
ETH Zurich
2021-2024
Delaware Academy of Medicine
1988
University of Cambridge
1968
Abstract The present study investigates the multiphasic nature of mechanical behavior human dermis. Motivated by experimental observations and consideration its composition, a quadriphasic model dermis is proposed, distinguishing solid matrix components, interstitial fluid charged constituents moving within fluid, i.e., anions cations. Compression tensile experiments with without change osmolarity bath are performed to characterize chemo-mechanical coupling in Model parameters determined...
The present study investigates the layer-specific mechanical behavior of human skin. Motivated by skin's histology, a biphasic model is proposed which differentiates between epidermis, papillary and reticular dermis, hypodermis. Inverse analysis ex vivo tensile in suction experiments yields parameters for each layer predicts stiff dermis successively softer epidermis Layer-specific simulations underlines dominating role loading. Furthermore, it shows that observed out-of-plane deflection...
Abstract Conventional venipuncture is invasive and challenging in low middle‐income countries. Conversely, point‐of‐care devices paired with fingersticks, although less invasive, suffer from high variability blood volume collection. Recently approved microsampling address some of these issues but remain cost‐prohibitive for resource‐limited settings. In this work, a cost‐effective device described the collection liquid minimal invasiveness sufficient retrieval laboratory analyses or...
Peptides represent a rapidly expanding class of drugs with broad therapeutic potential. However, due to their large molecular weight and susceptibility degradation in the gastrointestinal tract, most peptide are administered via subcutaneous (SC) injections. Despite extensive research, painless delivery platform for these is still lacking. Recently, an octopus-inspired buccal patch has shown promise addressing this challenge by leveraging synergistic combination mechanical stretching...
Abstract Supraphysiological stretches are exploited in skin expanders to induce tissue growth for autologous implants. As pregnancy is associated with large levels of sustained stretch, we investigated whether occurs pregnancy. Therefore, combined a mechanical model and the observations from suction experiments on several body locations five pregnant women at different gestational ages. The measurements show continuous increase stiffness, largest change observed during last trimester. A...
Aging leads to biochemical and biomechanical changes in skin, with biological functional consequences. Despite extensive literature on skin aging, there is a lack of studies which investigate the maturation tissue connect microscopic its macroscopic behavior as it evolves over time. The present work addresses this knowledge gap using multiscale characterization murine model considering newborn, adult aged mice. Monotonic uniaxial loading, tension relaxation change bath, loading failure tests...
Abstract The buccal mucosa is a highly interesting site for non-invasive drug delivery due to its relatively permeable epithelium and good accessibility. Recently, device-based systems have enabled the of macromolecular drugs by leveraging mechanical stretching forces on tissue assist diffusion. Despite successful exploitation route with such systems, biomechanics are still poorly characterized understood lack adequate characterization methods. Therefore, we propose combination physiological...
Human skin equivalents (HSEs) serve as important tools for mechanistic studies with human cells, drug discovery, pre-clinical applications in the field of tissue engineering and transplantation on defects. Besides cellular extracellular matrix (ECM) components used HSEs, physical constraints applied scaffold during HSEs maturation influence organization, functionality, homogeneity. In this study, we introduce a 3D-printed culture insert that exposes bi-layered to static radial constraint...