A5020819225- Cardiac Valve Diseases and Treatments
- Aortic Disease and Treatment Approaches
- Infective Endocarditis Diagnosis and Management
- Cardiac Structural Anomalies and Repair
- Cardiac and Coronary Surgery Techniques
- Aortic aneurysm repair treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Congenital Heart Disease Studies
- Cardiac pacing and defibrillation studies
- Coronary Artery Anomalies
- Mechanical Circulatory Support Devices
- Coronary Interventions and Diagnostics
- Cardiovascular Issues in Pregnancy
- Cardiac Arrhythmias and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Cardiac Imaging and Diagnostics
- Blood transfusion and management
- Cardiomyopathy and Myosin Studies
- Atrial Fibrillation Management and Outcomes
- Cardiac tumors and thrombi
- Single-cell and spatial transcriptomics
- Tissue Engineering and Regenerative Medicine
- Infectious Aortic and Vascular Conditions
- Trauma Management and Diagnosis
- Muscle activation and electromyography studies
University Hospital Frankfurt
2018-2025
Goethe University Frankfurt
2018-2025
Klinikum Frankfurt Höchst
2024
Cardiovascular Center Frankfurt
2023
Society of Thoracic Surgeons
2020
Kerckhoff Klinik
2016-2018
University of Zurich
2014-2017
University Hospital of Zurich
2013-2017
Charles University
2009-2016
University Hospital Hradec Králové
2009-2016
BACKGROUND Patient blood management (PBM) measures have been shown to be effective in reducing transfusions while maintaining patient outcome. The issuance of transfusion guidelines is seen as being key the success PBM programs. As introduction alone did not visibly reduce our center, a monitoring and feedback program was established. aim study show effectiveness such cost. STUDY DESIGN AND METHODS We designed prospective, interventional cohort with 3‐year time frame (January 1, 2012...
Abstract OBJECTIVES The goal was to develop a scoring system predict the 30-day mortality rate for patients undergoing surgery acute type A aortic dissection on basis of German Registry Acute Type Aortic Dissection (GERAADA) data set and provide Web-based application standard use. METHODS total 2537 enrolled in GERAADA who underwent between 2006 2015 were analysed. Variable selection performed using R-package FAMoS. robustness results confirmed via bootstrap procedure. coefficients final...
Left atrial appendage (LAA) occlusion has emerged as an interesting alternative to oral anticoagulation (OAC) for stroke prevention in patients with fibrillation (AF). We report the safety, efficacy, and durability of concomitant device-enabled epicardial LAA during open-heart surgery. In addition long-term follow-up, we evaluate impact on risk this selected population. A total 291 AtriClip devices were deployed epicardially (mean CHA2DS2-VASc-Score: 3.1 ± 1.5) undergoing surgery (including...
Pathological cardiac hypertrophy is a leading cause of heart failure, but knowledge the full repertoire cells and their gene expression profiles in human hypertrophic missing. Here, by using large-scale single-nucleus transcriptomics, we present transcriptional response cardiomyocytes to pressure overload caused aortic valve stenosis describe major alterations cellular crosstalk. Hypertrophied had reduced input from endothelial fibroblasts. Genes encoding Eph receptor tyrosine kinases,...
We present our surgical management of a mechanical transcatheter aortic valve replacement (TAVR) complication an anterior mitral leaflet (AML) perforation with infective endocarditis. Management consisted TAVR explantation, transaortic patch plasty the AML perforation, laceration by valve, and replacement. In cases high operative risk in technically demanding situation, surgeon should aim to operate early avoid extensive trauma long operation time addressing through aorta choosing repair...
The replacement of the aortic root and valve with a composite graft (Bentall-de Bono procedure) is valid treatment option for patients an aneurysm pathology. standard approach still full sternotomy. In this video tutorial, we present Bentall-de procedure using self-made in minimally invasive technique through upper ministernotomy.
Background: The German registry of aortic dissections type A (GERAADA) is a large European documenting patients with dissection who have undergone surgical repair. This analysis investigated potential association between the incidence (AADA) and lunar cycles, day week, or weather conditions. Methods: Data from 2,388 were analysed for two endpoints: AADA surgery per (analysed using Poisson regression to account overdispersed data) early mortality after logistic mixed centre heterogeneity). In...
Abstract Objectives Mycobacterium chelonae is a rapid-growing non-tuberculous mycobacterium that has occasionally been described in connection with foreign material infections, e.g. after orthopaedic joint replacement or cosmetic surgery. In recent outbreak, several cases of M. endocarditis associated biological heart valve prostheses were reported. Case history A 64-year-old female patient myalgia and recurrent swelling presented to our hospital. Initially suspected for rheumatoid...
In patients after aortic valve surgery, the quality of life is hypothesized to be influenced by type procedure. A cross-sectional study on postoperative was carried out in valve-sparing surgery (with regards age patient), Ross procedure and mechanical replacement.Quality studied 139 divided into four groups (Y - at below 50 years, mean 36.2 years; O years over, 59.2 R procedure, 37.8 M replacement 39.2 years). SF-36 Short Form valve-specific questionnaires were mailed 6 months or later...
The Ascyrus Medical Dissection Stent (AMDS) has been recently introduced as an alternative for total arch replacement in acute aortic dissection type A (AADA). aim of this study was to evaluate the postoperative outcomes after AMDS treatment a large contemporary cohort AADA patients.Data acquisition performed retrospectively at 2 German centres between 2020 and 2022 comprised perioperative parameters results all patients. All patients treated with were included study. primary end point...
Abstract Aims Cardiac fibrosis drives the progression of heart failure in ischaemic and hypertrophic cardiomyopathy. Therefore, development specific anti-fibrotic treatment regimens to counteract cardiac is high clinical relevance. Hence, this study examined presence persistent fibroblast activation during longstanding human disease at a single-cell resolution identify putative therapeutic targets pathological patients. Methods results We used single-nuclei RNA sequencing with tissues from...
Diagnostic laboratory tests are an integral part of managing hospitalized patients. In particular, patients in the intensive care units (ICUs) can experience a concerning amount blood loss due to diagnostic testing, which increase risk developing iatrogenic anemia. Several interventions exist curtail avoidable loss, for example computerized decision support, smaller phlebotomy tubes, and other conservation devices. Nevertheless, use these is not standardized. Therefore, objective our study...
Objective Ventricular secondary mitral regurgitation (SMR) (Carpentier type IIIb) results from left ventricular (LV) remodelling, displacement of papillary muscles and tethering leaflets. The most appropriate treatment approach remains controversial. We aimed to assess the safety efficacy standardised relocation both (subannular repair) at 1-year follow-up (FU). Methods REFORM-MR (Reform-Mitral Regurgitation) is a prospective, multicentre registry that enrolled consecutive patients with SMR...
Abstract OBJECTIVES Several short-term analyses from German Registry for Acute Aortic Dissection Type A (GERAADA) have been published. This study investigated whether risk factors are transferable to the long-term prognosis of patients. METHODS Thirty-three centres with 2686 patients participated in follow-up. total 1164 died, 1063 survived and 459 were lost follow-up during timeframe (mean duration: 10.2 years). Long-term mortality cohort was compared an age-stratified, population. RESULTS...
Abstract OBJECTIVES The aim of this multicentre study was to demonstrate the safety and clinical performance E-vita OPEN NEO Stent Graft System (Artivion, Inc.) in treatment aneurysm or dissection, both acute chronic, ascending aorta, aortic arch descending thoracic aorta. METHODS In observational 12 centres performed Europe Asia patients were enrolled between December 2020 March 2022. All underwent frozen elephant trunk using System. Primary end point rate all-cause mortality at 30 days...
The objective of the European Multicenter Registry to Assess Outcomes in coronary artery bypass grafting (CABG) patients (DuraGraft Registry) was determine clinical outcomes and quality life (QoL) after contemporary CABG that included isolated combined CABG/valve procedures, using an endothelial damage inhibitor (DuraGraft) intraoperatively for conduit preservation. Here, we report patient cohort undergoing CABG.The primary outcome composite all-cause death, myocardial infarction (MI), or...