A5090475286- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Blood transfusion and management
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Arrest and Resuscitation
- Trauma and Emergency Care Studies
- Mechanical Circulatory Support Devices
- Erythropoietin and Anemia Treatment
- Blood donation and transfusion practices
- Cardiac Structural Anomalies and Repair
- Venous Thromboembolism Diagnosis and Management
- Healthcare Technology and Patient Monitoring
- Heart Failure Treatment and Management
- Atrial Fibrillation Management and Outcomes
- Airway Management and Intubation Techniques
- Iron Metabolism and Disorders
- Anesthesia and Pain Management
- Trauma Management and Diagnosis
- Burn Injury Management and Outcomes
- Abdominal Trauma and Injuries
- Acute Kidney Injury Research
- Acute Ischemic Stroke Management
- Hemodynamic Monitoring and Therapy
- Intracerebral and Subarachnoid Hemorrhage Research
- Healthcare Operations and Scheduling Optimization
- Obstructive Sleep Apnea Research
University Hospital of Zurich
2016-2025
University of Zurich
2017-2024
University Hospital Münster
2023-2024
Outcomes Research Consortium
2023
Bristol-Myers Squibb (Switzerland)
2021
B. Braun (Switzerland)
2021
Pharmacosmos (Denmark)
2021
Alexion Pharma (Switzerland)
2021
International Rescue Committee
2018
Summary Trauma promotes trauma‐induced coagulopathy, which requires urgent treatment with fixed‐ratio transfusions of red blood cells, fresh frozen plasma and platelet concentrates, or goal‐directed administration coagulation factors based on viscoelastic testing. This retrospective observational study compared two time periods before (2005–2007) after (2012–2014) the implementation changes in trauma management protocols included: use management; admission patients to designated centres;...
Background Patient monitoring is indispensable in any operating room to follow the patient’s current health state based on measured physiological parameters. Reducing workload helps free cognitive resources and thus influences human performance, which ultimately improves quality of care. Among many methods available assess perceived workload, National Aeronautics Space Administration Task Load Index (NASA-TLX) provides most widely accepted tool. However, only few studies have investigated...
A Patient Blood Management programme was established at the University Hospital of Zurich, along with a monitoring and feedback programme, beginning 2014 first analysis reported in 2015. Our study aimed to investigate further impact this on transfusion requirements related costs. We included adult patients discharged between 2012 2017. total 213,882 underwent analysis: 66,659 baseline period (2012-2013); 35,309 year after introduction (2014) 111,914 continued sustainability (2015-2017). The...
Objectives: To investigate the optimal duration of venoarterial extracorporeal membrane oxygenation (ECMO) for cardiogenic shock refractory to medical therapies after cardiac surgery and whether its prolonged use is justified. Data Sources: Previously published articles on postcardiotomy ECMO. Study Selection: Articles reporting early outcome ECMO in adult patients were identified through a systematic review literature. Extraction: prespecified patients’ characteristics, operative variables,...
Pain is frequently encountered in the prehospital setting and needs to be treated quickly sufficiently. However, incidences of insufficient analgesia after treatment by emergency medical services are reported as high 43%. The purpose this analysis was identify modifiable factors a specific patient cohort that influence pain suffered patients when admitted hospital.For purpose, retrospective observational study included all with significant Swiss physician-staffed helicopter service between...
Background A significant proportion of patients with coronavirus disease 19 (COVID-19) suffer from excessive coagulation activation and coagulopathy which is associated an increased risk venous arterial thromboembolism adverse outcome. Our study investigates markers the incidence thromboembolic events in COVID-19 receiving recommended anticoagulation strategies. Methods In a retrospective single-center analysis at University Hospital Zurich, Switzerland, we investigated 31 adult between...
Extracorporeal life support (ECLS) therapy is increasingly used for cardiac and respiratory postcardiotomy, refractory cardiogenic shock cardiopulmonary resuscitation. This study aims to describe in-hospital mortality of patients requiring ECLS, identify independent predictors associated with analyze changes over time.This retrospective includes all adult ECLS cases at the University Hospital Zurich, a designated center in Switzerland, period 2007 2019.ECLS was required 679 (median age 60...
The use of veno-venous extracorporeal membrane oxygenation (V-V ECMO) has rapidly increased in recent years. Today, applications V-V ECMO include a variety clinical conditions such as acute respiratory distress syndrome (ARDS), bridge to lung transplantation and primary graft dysfunction after transplantation. purpose the present study was investigate in-hospital mortality adult patients undergoing therapy determine independent predictors associated with mortality.This retrospective...
Rivaroxaban (RXA) is a direct oral factor Xa (Xa) antagonist with short half-life and fast onset offset of effect. Before elective surgery, discontinuation recommended an interval at least > 24 hours. In clinical practice, this is, however, not always sufficient to achieve residual RXA plasma concentration deemed appropriate for defined as ≤ 50 mcg/L. Our study aimed identifying factors associated higher-than-expected in large group real-life patients.This retrospective single-centre...
BACKGROUND This study investigates the impact of preoperative calculated rivaroxaban (RXA) plasma concentration on perioperative red blood cell (RBC) loss. STUDY DESIGN AND METHODS In this retrospective single‐center study, we identified patients with RXA intake according to a determination levels within 96 hours before surgery. at beginning surgery was then from last using single‐compartment pharmacokinetic model four categories (≤20, 21‐50, 51‐100, and >100 μg/L). Patients were...
At the University Hospital Zurich (USZ) and Cantonal of Lucerne (LUKS) an individualized goal-directed coagulation transfusion algorithm was introduced implemented before 2012 (Coagulation USZ: USZ-Alg; LUKS: LUKS-Alg). Main differences between both algorithms are: 1) A target haematocrit-range 0.21–0.24 (USZ-Alg) vs. a lower haematocrit limit only (LUKS-Alg). 2) Blind coagulation-package in selected cases (LUKS-Alg only). 3) Factor XIII substitution is considered earlier according to...
Summary In patients with pre‐operative anaemia undergoing cardiac surgery, combination treatment intravenous iron, subcutaneous erythropoietin alpha, vitamin B12 and oral folic acid reduces allogeneic blood product transfusions. It is unclear if certain types of particularly benefit from this treatment. We performed a post‐hoc analysis anaemic randomised trial on the ‘Effect ultra‐short‐term iron deficiency or surgery’. used linear regression analyses to examine efficacy compared placebo...
BACKGROUND Approximately every third surgical patient is anemic. The most common form, iron deficiency anemia, results from persisting iron‐deficient erythropoiesis (IDE). Zinc protoporphyrin (ZnPP) a promising parameter for diagnosing IDE, hitherto requiring blood drawing and laboratory workup. STUDY DESIGN AND METHODS Noninvasive ZnPP (ZnPP‐NI) measurements are compared to reference determination of the ZnPP/heme ratio by high‐performance liquid chromatography (ZnPP‐HPLC) analytical...