A5007279871- Intensive Care Unit Cognitive Disorders
- Hemophilia Treatment and Research
- Antibiotic Use and Resistance
- Respiratory Support and Mechanisms
- Cardiac, Anesthesia and Surgical Outcomes
- Sepsis Diagnosis and Treatment
- Ultrasound in Clinical Applications
- Blood Coagulation and Thrombosis Mechanisms
- Nosocomial Infections in ICU
- Innovations in Medical Education
- Clinical practice guidelines implementation
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Family and Patient Care in Intensive Care Units
- Antifungal resistance and susceptibility
- Hemodynamic Monitoring and Therapy
- COVID-19 Clinical Research Studies
- Pleural and Pulmonary Diseases
- Intracranial Aneurysms: Treatment and Complications
- Frailty in Older Adults
- Pneumonia and Respiratory Infections
- Antibiotic Resistance in Bacteria
- Disaster Response and Management
- Hepatocellular Carcinoma Treatment and Prognosis
- Anesthesia and Sedative Agents
- Radiology practices and education
Technical University of Munich
1994-2025
Klinikum rechts der Isar
2015-2025
Flinders University
2025
Ludwig-Maximilians-Universität München
2019
München Klinik
2019
Children's Hospital of Michigan
1998
Manchester Royal Infirmary
1998
Potters Bar Community Hospital
1998
National Institute for Biological Standards and Control
1998
Cornell University
1998
Scanning tunneling microscopy is based on the flow of an electrical current and thus cannot be used to directly image insulating material. It has been found, however, that a very thin film water (about one monolayer) adsorbed surface exhibits surprisingly high conductivity sufficient allow scanning microscope imaging at currents below 1 picoampere. Hydrophilic insulators, such as glass mica, can imaged in humid air. The same true for biological specimens deposited surfaces, demonstrated by...
Abstract The coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome 2 (SARS-CoV-2) has spread worldwide. Bacterial co-infections are associated with unfavourable outcomes in viral infections; however, microbiological and antibiotic data related to COVID-19 sparse. Adequate use of antibiotics line stewardship (ABS) principles is warranted during pandemic. We performed a retrospective study clinical characteristics 140 patients admitted between February April 2020...
Background Superinfections, including invasive pulmonary aspergillosis (IPA), are well-known complications of critically ill patients with severe viral pneumonia. Aim this study was to evaluate the incidence, risk factors and outcome IPA in COVID-19 Methods We prospectively screened 32 pneumonia for a time period 28 days using standardized protocol oberservation developement associated (CAPA). collected laboratory, microbiological, virological clinical parameters at defined timepoints...
The DIANA study aimed to evaluate how often antimicrobial de-escalation (ADE) of empirical treatment is performed in the intensive care unit (ICU) and estimate effect ADE on clinical cure day 7 following initiation. Adult ICU patients receiving therapy for bacterial infection were studied a prospective observational from October 2016 until May 2018. was defined as (1) discontinuation an case combination or (2) replacement with intention narrow spectrum, within first 3 days therapy. Inverse...
Abstract Background Acute kidney injury is a common complication after major surgery. In this study, we investigated whether an algorithm-guided goal-directed haemodynamic therapy (GDT) can improve renal outcome compared to good standard clinical care. Methods A total of 180 patients undergoing abdominal surgery were prospectively and randomly assigned one two groups: in the GDT group, treated with algorithm using transpulmonary thermodilution while care was applied control patients. Change...
Background and Purpose: Delayed cerebral ischemia (DCI) is the most important cause for a poor clinical outcome after subarachnoid hemorrhage. The aim of this study was to assess whether goal-directed hemodynamic therapy (GDHT), as compared standard care, reduces rate DCI Methods: We conducted prospective randomized controlled trial. Patients >18 years age with an aneurysmal hemorrhage were enrolled randomly assigned or GDHT. Advanced monitoring predefined GDHT algorithms applied in...
Severe COVID-19 induced acute respiratory distress syndrome (ARDS) often requires extracorporeal membrane oxygenation (ECMO). Recent German health insurance data revealed low ICU survival rates. Patient characteristics and experience of the ECMO center may determine intensive care unit (ICU) survival. The current study aimed to identify factors affecting patients.673 ARDS patients treated in 26 centers between January 1st 2020 March 22nd 2021 were included. Data on clinical characteristics,...
Abstract Purpose Timely and accurate data on the epidemiology of sepsis are essential to inform policy decisions research priorities. We aimed investigate validity inpatient administrative health (IAHD) for surveillance quality assurance care. Methods conducted a retrospective validation study in disproportional stratified random sample 10,334 cases age ≥ 15 years treated 2015–2017 ten German hospitals. The accuracy coding risk factors mortality IAHD was assessed compared reference standard...
Background Clinical practice guidelines are important tools for clinical decision support, but monitoring guideline adherence manually is highly resource-intensive. Therefore, we developed an automated system evaluating based on computer-interpretable representations of guidelines. We implemented the across multiple university hospitals and assessed its validity performance by comparing evaluations to those conducted medical professionals. Methods selected six representative recommendations...
Lung ultrasound (LUS) is a well-established method that can exclude pneumothorax by demonstration of pleural sliding and the associated artifacts. The positive diagnosis more difficult to obtain relies on detection edge pneumothorax, called "lung point." Yet, anesthesiologists are not widely taught these techniques, even though their patients susceptible either through trauma or as result central line placement regional anesthesia techniques performed near thorax. In anticipation an...
Sepsis is as a life-threatening organ dysfunction caused by dysregulated host response to an infection. The mortality of sepsis and particular septic shock very high. Treatment mostly focuses on infection control but specific intervention that targets the underlying pathological lacking present time. investigators hypothesize early therapeutic plasma exchange (TPE) will dampen maladaptive removing injurious mediators thereby limiting improving survival in patients with shock. Although small...
To assess the prevalence of Herpes simplex and Cytomegalovirus infection in respiratory samples critically-ill COVID-19 patients, its role outcome mortality influence dexamethasone treatment early stage SARS-CoV-2 infection.All mechanically ventilated patients treated on ICU between March 2020 January 2021 were included. Respiratory specimens tested for virus (HSV) type 1, 2 (CMV) by quantitative real-time PCR. Clinical parameters compared cohorts with without HSV-1- infection.134 a median...
Herpes simplex virus (HSV) is frequently detected in the respiratory tract of mechanically ventilated patients and associated with a worse outcome. The aim this study to determine whether antiviral therapy HSV-positive improves Prospective, multicentre, open-label, randomised, controlled trial parallel-group design. Adult, pneumonia HSV type 1 bronchoalveolar lavage (≥105 copies/mL) are eligible for participation will be randomly allocated (1:1) receive acyclovir (10 mg/kg body weight every...
Summary. In view of reports FVIII assay discrepancies in post‐infusion plasma samples depending on methods used, we compared results run by each four different following infusion rFVIII (Kogenate®). Nine persons with haemophilia A were infused two lots product. Plasma obtained at baseline, and 10 min, 30 1, 2, 4, 8, 12, 14, 48 h for measurement FVIII. chromogenic, one‐stage APTT using three types activators: micronized, silica, ellagic acid, kaolin. The same reference standard was used...
Intensive care unit (ICU) capacity is a scant and precious resource in hospitals. Therefore, an optimal occupancy rate as well detailed occupation planning of great importance. Most literature deals with admission to the ICU, while only few discuss discharge from ICU. Specifically, delay transfer ICU can cause shortness beds, jeopardize urgent patient treatment lead decrease quality economic downsides. This study examined incidence, costs reasons for delayed analyzed influence department was...
Background: Coronavirus disease 2019 (COVID-19) has become a pandemic. Bacterial superinfections seem to be associated with higher mortality in COVID-19 patients intensive care units (ICUs). However, details on the prevalence and species distribution of secondary infections are limited. Moreover, increasing use dexamethasone may pose an additional risk superinfections.Methods: We performed single-center retrospective study clinical microbiological characteristics 154 admitted ICU between...
Abstract Background Infections caused by third generation cephalosporin-resistant Enterobacteriaceae (3GCREB) are an increasing healthcare problem. We aim to describe the 3GCREB infection incidence and compare it prevalence upon admission. In addition, we infections 3GCREB, which also carbapenem resistant (CRE). Methods 2014–2015, performed prospective surveillance in clinically relevant patient specimens (screening excluded). counted as hospital-acquired (HAI) when was detected after day...