A5054898825- Clostridium difficile and Clostridium perfringens research
- Infection Control in Healthcare
- Nosocomial Infections in ICU
- Antibiotic Use and Resistance
- Viral gastroenteritis research and epidemiology
- Microscopic Colitis
- Infection Control and Ventilation
- Food Safety and Hygiene
- Probiotics and Fermented Foods
- Salmonella and Campylobacter epidemiology
- Antimicrobial Resistance in Staphylococcus
- Primary Care and Health Outcomes
- Gut microbiota and health
- Airway Management and Intubation Techniques
- Anesthesia and Sedative Agents
- Patient Safety and Medication Errors
- Intensive Care Unit Cognitive Disorders
- Antibiotic Resistance in Bacteria
- Global Maternal and Child Health
- Listeria monocytogenes in Food Safety
- Gastrointestinal motility and disorders
- Diet and metabolism studies
- Patient-Provider Communication in Healthcare
- Electronic Health Records Systems
- Sleep and Wakefulness Research
University of Michigan
2020-2025
Animal and Plant Health Agency
2021
Zoetis (United States)
2021
University of Wisconsin–Madison
2014-2020
Michigan United
2020
Biology of Infection
2018
Engineering Associates (United States)
2016-2018
Evans Analytical Group (United States)
2018
Wisconsin Division of Public Health
2017
Iowa City Public Library
2016
Objectives There are only 0.70 licensed physicians per 1000 people in India. Thus, pharmacies a primary source of healthcare and patients often seek their services directly, especially village settings. However, there is wide variability pharmacy employee's training, which contributes to inappropriate antibiotic dispensing misuse. These practices increase the risk resistance poor patient outcomes. This study seeks better understand factors that drive among employees India's communities....
Antibiotic resistance is a global public health crisis. In India alone, multi-drug resistant organisms are responsible for over 58,000 infant deaths each year. A major driver of drug antibiotic misuse, which pervasive phenomenon worldwide. Due to shortage trained doctors, access licensed allopathic doctors limited in India's villages. Pharmacists and unlicensed medical providers commonly the primary sources healthcare. Patients themselves also key participants decision treat an illness with...
Clostridium difficile is the most common cause of hospital-acquired infections, responsible for >450000 infections annually in USA. Probiotics provide a promising, well-tolerated adjunct therapy to standard C. infection (CDI) treatment regimens, but there paucity data regarding their effectiveness an initial CDI. We conducted pilot randomized controlled trial 33 participants from February 2013 2015 determine feasibility and health outcomes probiotic use patients with mild moderate The...
Hospital acquired infections occur at higher rates in low- and middle-income countries, like India, than high-income countries. Effective implementation of infection control practices is crucial to reducing the transmission hospital hospitals worldwide. Yet, no comprehensive assessments barriers sustained, successful interventions have been performed Indian healthcare settings date. The Systems Engineering Initiative for Patient Safety (SEIPS) model examines problems through lens...
Despite intensified efforts to reduce hospital-onset Clostridium difficile infection (HO-CDI), its clinical and economic impacts continue worsen. Many institutions have adopted bundled interventions that vary considerably in composition, strength of evidence, effectiveness. Considerable gaps remain our knowledge intervention effectiveness disease transmission, which hinders HO-CDI prevention. We developed an agent-based model C. transmission a 200-bed adult hospital using studies from the...
Infection by Staphylococcus aureus (S. aureus) is a major cause of morbidity and mortality. Colonization S. increases the risk infection. Little known about decolonization strategies for beyond antibiotics, however probiotics represent promising alternative. A randomized controlled trial was conducted to determine efficacy Lactobacillus rhamnosus (L. rhamnosus) HN001 in reducing carriage at multiple body sites. One hundred thirteen subjects, positive carriage, were recruited from William...
Perturbations in the gastrointestinal microbiome caused by antibiotics are a major risk factor for Clostridium difficile infection (CDI). Probiotics often recommended to mitigate CDI symptoms; however, there exists only limited evidence showing probiotic efficacy CDI. Here, we examined changes GI microbiota study population where treatment was associated with significantly reduced duration of diarrhea. Subjects being treated standard care primary episode were randomized or placebo 4 weeks....
Abstract Background ICU readmissions are associated with increased morbidity, mortality, and healthcare costs. As patient complexity increases care practices evolve, the contemporary epidemiology of remains unclear. We aimed to examine readmission rates timing across multiple health systems, focusing on unplanned occurring within 24, 48, 72 hours after discharge. Methods performed a retrospective cohort study using federated data from Common Longitudinal Format (CLIF) Consortium, comprising...
<h3>Importance</h3> <i>Clostridioides difficile</i>infection is the most common hospital-acquired infection in United States, yet few studies have evaluated cost-effectiveness of control initiatives targeting<i>C difficile</i>. <h3>Objective</h3> To compare 9<i>C difficile</i>single intervention strategies and 8 multi-intervention bundles. <h3>Design, Setting, Participants</h3> This economic evaluation was conducted a simulated 200-bed tertiary, acute care, adult hospital. The study relied...
The prevalence of colonization with toxigenic Clostridium difficile among patients hematological malignancies and/or bone marrow transplant at admission to a 566-bed academic medical care center was 9.3%, and 13.3% colonized developed symptomatic disease during hospitalization. This population may benefit from targeted C. infection control interventions. Infect Control Hosp Epidemiol 2017;38:718–720
We examine factors associated with hand hygiene practices of hospital patients. Hygiene in the decreased compared to that at home, and home were strongly practices. Understanding leveraging intrinsic value some patients associate may be important for improving overall decreasing healthcare-associated infections.
Healthcare facilities in low- and middle-income countries, including the Philippines, face substantial challenges achieving effective infection control. Early stages of interventions should include efforts to understand perceptions held by healthcare workers who participate control programs. We performed a qualitative study examine facilitators barriers at an 800-bed, private, tertiary hospital Manila, Philippines. Semi-structured interviews were conducted with 22 nurses, physicians,...
Abstract Objective: Clostridioides difficile infection (CDI) is rapidly increasing in children’s hospitals nationwide. Thus, we aimed to compare the effectiveness of 9 prevention interventions and 6 multiple-intervention bundles at reducing hospital-onset CDI asymptomatic C. colonization. Design: Agent-based simulation model transmission. Setting: Computer-simulated, 80-bed freestanding, tertiary-care pediatric hospital, including 8 identical wards with 10 single-bed patient rooms each....