A5057998743- Glaucoma and retinal disorders
- Corneal surgery and disorders
- Intraocular Surgery and Lenses
- Ocular Surface and Contact Lens
- Ophthalmology and Visual Impairment Studies
- Cerebral Venous Sinus Thrombosis
- Ophthalmology and Eye Disorders
- Retinal Diseases and Treatments
- Retinopathy of Prematurity Studies
- Older Adults Driving Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Visual perception and processing mechanisms
- Retinal Imaging and Analysis
- Retinal and Macular Surgery
- Retinal Development and Disorders
- Advanced Drug Delivery Systems
- Advancements in Transdermal Drug Delivery
- Ocular Diseases and Behçet’s Syndrome
- Photoreceptor and optogenetics research
- Ocular Infections and Treatments
- Acute Ischemic Stroke Management
- Pharmaceutical Economics and Policy
- Drug-Induced Ocular Toxicity
- Retinal and Optic Conditions
- Optical Coherence Tomography Applications
Emory University
2005-2024
University of Nebraska Medical Center
2008-2022
Emory and Henry College
2022
Visual Sciences (United States)
2019-2021
Nebraska Medical Center
2007-2020
Sunnybrook Health Science Centre
2020
Health Sciences Centre
2020
University of Toronto
2020
University of Kentucky
2011-2013
University of Mississippi Medical Center
2009-2011
To test the hypothesis that coated microneedles can deliver drugs into eye via intrascleral and intracorneal routes in a minimally invasive manner.Solid metal measuring 500 to 750 microm length were with model drugs, protein, DNA; inserted nonpreserved human cadaveric sclera; imaged. Microneedles sodium fluorescein then rabbit cornea vivo. After needle removal, concentration anterior segment of was measured for 24 hours. Similar experiments performed using pilocarpine-coated microneedles,...
To compare the intraocular pressure (IOP)-lowering efficacy and safety of netarsudil once daily (QD) timolol twice (BID).Double-masked, randomized, phase 3, noninferiority study.Patients with open-angle glaucoma or ocular hypertension (unmedicated baseline IOP >20 to <30 mm Hg at 8:00 AM) were randomized ophthalmic solution 0.02% QD (PM) 0.5% BID. The primary endpoint was mean AM, 10:00 4:00 PM week 2, 6, month 3 in patients <25 (per-protocol population). Safety recorded over 6-month...
To evaluate the pharmacokinetics of periocular injections: posterior subtenon (PST), retrobulbar (RB), and subconjunctival (SC) injection.Two sodium fluorescein (NaF) concentrations, 2.5 mg in 0.1 mL (NaF1) 0.5 (NaF2) were injected into live rabbits by PST (NaF1 n = 4, NaF2 3), RB 10), SC 6), intravenous (IV, NaF1 6) routes euthanatized 8) route. NaF concentrations choroid/retina, vitreous, anterior segment measured ocular fluorophotometry. The level contralateral choroid/retina was used as...
Iontophoresis is an electrical-current-based, noninvasive drug-delivery technology, which particularly suitable for intraocular drug delivery. Current ocular iontophoresis devices use low current intensities that significantly limit macromolecule and nanoparticle (NP) delivery efficiency. Increasing intensity leads to tissue damage. Here, device based on a hydrogel ionic circuit (HIC), high-efficiency NP delivery, described. The HIC-based capable of minimizing Joule heating, effectively...
Objectives: To investigate the daytime vs nighttime differences in intraocular pressure (IOP), aqueous humor dynamics, central cornea thickness, and blood among a cohort of healthy volunteers.Methods: Thirty volunteers (mean [SD] age, 57.0 [8.6] years) were enrolled study.Individuals underwent 1 visit for measurement dynamics.Measurements included IOP by pneumatonometry, flow fluorophotometry, outflow facility fluorophotometry tonography, uveoscleral mathematical calculation, thickness...
In this work, the biomechanical responses of optic nerve head (ONH) to acute elevations in intracranial pressure (ICP) were systematically investigated through numerical modeling. An orthogonal experimental design was developed quantify influence ten input factors that govern anatomy and material properties ONH on peak maximum principal strain (MPS) lamina cribrosa (LC) postlaminar neural tissue (PLNT). Results showed sensitivity various region-specific. LC, MPS most strongly dependent...
To evaluate risk factors for sclerotomy leakage in 23-gauge sutureless pars plana vitrectomy 219 patients.Nested case-control study involving 48 patients with wound leaks (visible on-table requiring sutures) and 171 control subjects without leaks. Patients received either a conventional incision at 45°, which was then changed to 90° midincision, or an extremely oblique (OSI) 10°, 30° midincision. Risk studied included age, gender, laterality, surgical duration, (OSI vs. incision),...
Axonopathy is a hallmark of many neurodegenerative diseases including glaucoma, where elevated intraocular pressure (ocular hypertension, OHT) stresses retinal ganglion cell (RGC) axons as they exit the eye and form optic nerve. OHT causes early changes in nerve such axon atrophy, transport inhibition, gliosis. Importantly, these appear to occur prior irreversible neuronal loss, making them promising points for diagnosis glaucoma. It unknown whether has similarly effects on function RGC...
Introduction: Aqueous humor and its dynamics (AHD) serve numerous functions to sustain ocular health clear vision. Current methods assess AHD have led improved understanding of physiology, pathologies caused by abnormal intraocular pressures (IOP), treatments return IOP healthy levels. However, the assumptions limitations inherent in these been problematic. New on horizon are showing promise greatly advance field.Areas covered: This review summarizes assessment techniques use today including...
Current knowledge of traumatic ocular injury is still limited as most studies have focused on the injuries that happened at anterior part eye, whereas damage to optic nerve known neuropathy (TON) poorly understood. The goal this study understand mechanism TON following primary blast through a fluid-structure interaction model. An axisymmetric three-dimensional (3D) eye model with detailed orbital components was developed capture dynamics under wave. Our numerical results demonstrated...
To characterize the relative contributions of intraocular pressure (IOP) and intracranial (ICP) on lamina cribrosa (LC) behavior, specifically LC depth (LCD) peak strain. An axially symmetric finite element model posterior eye was constructed with an elongated optic nerve retro-orbital subarachnoid space ensheathed by pia dura mater. The mechanical environment in evaluated ICP ranging from 5 to 15 mmHg IOP 10 45 mmHg. LCD strains at various levels were estimated using full factorial...
Purpose: The Water-Drinking Test (WDT) has been shown to predict the diurnal IOP change. This study evaluates factors that may affect WDT results. Methods: was conducted on 203 glaucoma patients who had undergone trabeculectomy (53) or tube surgery (31), a medically controlled open-angle (82) closed-angle (37) glaucoma. measured at baseline and then every 15 minutes over one-hour period after drinking water. main outcome measures were change (increase in from baseline) all measurement time...
Purpose Orbital veins such as the retinal and episcleral drain into cavernous sinus, an intracranial venous structure. We studied effects of acute pressure (ICP) elevation on pressure, intraocular vein diameter in established non-survival pig model.Methods In six adult female domestic pigs, we increased ICP 5 mm Hg increments using saline infusion through a lumbar drain. measured (using parenchymal monitor), pneumatonometer), venomanometer), OCT images) arterial blood at each stable...
To study the refractive and visual outcomes, including surgically induced astigmatism, of laser in situ keratomileusis (LASIK) after flap buttonholes incomplete flaps.Rajendra Prasad Center for Ophthalmic Sciences, All India Institute Medical New Delhi, India.This was a retrospective case series 15 patients (15 eyes) who had LASIK complications (6 eyes with 9 flaps). The second surgery performed refraction stable 2 months. outcomes were studied.After complication, spheroequivalent did not...