A5029065397- Retinoids in leukemia and cellular processes
- Acute Myeloid Leukemia Research
- Vitamin D Research Studies
- Platelet Disorders and Treatments
- Erythrocyte Function and Pathophysiology
- Blood groups and transfusion
- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Cancer Treatment and Pharmacology
- Cell death mechanisms and regulation
- Protein Kinase Regulation and GTPase Signaling
- Coronary Interventions and Diagnostics
- Neuroblastoma Research and Treatments
- Tissue Engineering and Regenerative Medicine
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Neuropeptides and Animal Physiology
- Spine and Intervertebral Disc Pathology
- Acute Lymphoblastic Leukemia research
- Hemophilia Treatment and Research
- Cytokine Signaling Pathways and Interactions
- Glioma Diagnosis and Treatment
- Bone health and osteoporosis research
- Bone and Joint Diseases
- Melanoma and MAPK Pathways
University of North Carolina at Chapel Hill
2025
John Brown University
2025
Hospital for Special Surgery
2020-2023
University of Connecticut
2016-2020
Université Côte d'Azur
2018
Hartford Hospital
2018
University of California, San Diego
1978-2017
University of Missouri
2015-2016
University of California San Diego Medical Center
2016
Rutgers, The State University of New Jersey
2004-2014
Abstract Trans-differentiation of stem cells shows promise for use in tissue repair medicine. Although poorly defined, mesenchymal (MSC) appear useful applications Despite the low frequency MSC, they are relatively easy to expand. The expression MHC class II on however, could deter their medicine, since these molecules stimulate an allogeneic host response. This study sought compare immune stimulatory and suppressive effects MSC. Primary human MSC were cultured from bone marrow aspirates...
Gigaxonin is an intermediate filament (IF)-interacting partner belonging to the Kelch-like (KLHL) protein family. encoded by KLHL16 gene, which mutated in Giant Axonal Neuropathy (GAN). The lack of functional gigaxonin GAN patient cells impairs IF proteostasis, leading focal abnormal accumulations IFs and compromised neuronal function. We hypothesized that forms molecular interactions via specific sequence motifs regulate proteostasis. goal this study was examine how distinct Kelch on...
Acute myelogenous leukemia (AML) is a disease characterized by dysregulated cell proliferation associated with impaired differentiation, and current treatment regimens rarely save the patient. Thus, new mechanism-based approaches are needed to improve prognosis of this disease. We have investigated in preclinical studies potential anti-leukemia use plant-derived polyphenol Silibinin (SIL) combination 1,25-dihydroxyvitamin D3 (1,25D). Although most leukemic blasts ex vivo responded...
Optimal cytoreductive surgery combined with intraoperative hyperthermic chemoperfusion (IHCP) is a therapy that potentially could improve survival in select group of patients advanced ovarian cancer. The purpose this study was to review the results and IHCP for cancer identify factors may predict which maximally benefit from aggressive treatment.Patients treated cytoreduction followed by were identified an database 1/2001 through 3/2004. Several including resection status, peritoneal index...
von Willebrand disease (vWD), the most common inherited bleeding disorder in humans, results from abnormalities plasma clotting protein factor (vWF). Severe (type III) vWD is autosomal recessive inheritance and associated with extremely low or undetectable vWF levels. We report a method designed to distinguish mRNA expression two alleles by PCR analysis of peripheral blood platelet RNA using DNA sequence polymorphisms located within exons gene. This approach was applied severe-vWD pedigree...
Background. Chemotherapy with a doxorubicin-containing regimen results in high overall response rates the treatment of metastatic adenocarcinoma breast; combination doxorubicin, etoposide, and cyclophosphamide has produced rate 84% untreated patients stage IV disease. Recent data suggest that selected groups disease treated high-dose chemotherapy stem cell support may enjoy unmaintained, long-term remission. This study was designed to establish feasibility administering infusional followed...
Kirsten sarcoma virus produced a low incidence of transient morphological transformation in primary cultures rat ovarian granulosa cells. In the presence epidermal growth factor, increased severalfold and two continuous cell lines were established. Epidermal naturally occurring polypeptide hormone, appears to act here as tumor promoter retrovirus-induced mesodermally derived epithelium.
Abstract It is now well known that in the mammalian body vitamin D converted by successive hydroxylations to 1,25‐dihydroxyvitamin (1,25D), a steroid‐like hormone with pleiotropic properties. These include important contributions control of cell proliferation, survival and differentiation, as regulation immune responses disease. Here, we present recent advances current understanding role 1,25D myelopoiesis lymphopoiesis, potential analogs (vitamin derivatives; VDDs) for hematopoietic...
AbstractDifferentiation therapy of cancer is being explored as a potential modality for treatment myeloid leukemia, and derivatives vitamin D are gaining prominence agents this form therapy. Cyclooxygenase (COX) inhibitors have been reported to enhance 1,25-dihydroxyvitamin D3 (1,25D)-induced monocytic differentiation promyeloblastic HL60 cells, but the mechanisms effect not fully elucidated, whether potentiation can occur in other types leukemia known. We found that combination with 1,25D...
Abstract Induction of terminal differentiation is a conceptually attractive approach for the therapy neoplastic diseases. Although vitamin D derivatives (deltanoids) can induce AML cells in vitro , so far deltanoids have not been successfully brought to clinic, due likelihood life‐threatening hypercalcemia. Here, we incubated freshly obtained blood from patients with plant antioxidant (PAOx), silibinin (SIL), alone or together deltanoid. Twenty (all subtypes except M3) were available this...
Mitogen-activated protein kinases (MAPKs) are important transducers of external signals for cell growth, survival, and other cellular responses including differentiation. Several MAPK cascades known with the MEK1/2-ERK1/2, JNK, p38MAPKs receiving most attention, but role MEK5-ERK5 in intracellular signaling deserves more scrutiny, as this pathway transmits that can complement ERK/2 signaling. We hypothesized ERK5 plays a control monocytic differentiation, which is disturbed myeloid leukemia....