A5007940145- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Cardiac Fibrosis and Remodeling
- Cardiac Structural Anomalies and Repair
- Graphene and Nanomaterials Applications
- Traumatic Brain Injury and Neurovascular Disturbances
- Cerebrospinal fluid and hydrocephalus
Sanford Consortium for Regenerative Medicine
2020-2023
University of California, San Diego
2019-2023
La Jolla Bioengineering Institute
2022-2023
A first-in-man clinical study on a myocardial-derived decellularized extracellular matrix hydrogel suggested the potential for efficacy in chronic myocardial infarction (MI) patients. However, little is understood about mechanism of action MI. In this study, authors investigated and by which can mitigate negative left ventricular (LV) remodeling rat MI model. Assessment cardiac function via magnetic resonance imaging demonstrated preservation LV volumes apical wall thickening. Differential...
Traumatic brain injury (TBI) affects millions of people each year and, in many cases, results long-term disabilities. Once a TBI has occurred, there is significant breakdown the blood-brain barrier resulting increased vascular permeability and progression injury. In this study, use an infusible extracellular matrix-derived biomaterial (iECM) for its ability to reduce modulate gene expression injured investigated. First, pharmacokinetics iECM administration mouse model characterized, robust...
Summary A first-in-man clinical study on a myocardial-derived decellularized extracellular matrix (ECM) hydrogel yielded evidence for potential efficacy in ischemic heart failure (HF) patients. However, little is understood about the mechanism of action chronic myocardial infarction (MI). In this we investigated and by which can mitigate negative left ventricular (LV) remodeling model MI. Assessment cardiac function via magnetic resonance imaging (MRI) demonstrated preservation LV volumes...
Abstract Biomaterials, such as extracellular matrix (ECM) hydrogels, have been widely used in preclinical studies injectable tissue engineering therapies; however, therapies are limited they can cause localized trauma or organ perforation. We developed a new ECM therapy, the low molecular weight fraction derived from decellularized, digested ECM, for intravascular infusion. This form of be infused after injury, specifically localize to injured tissues by coating leaky microvasculature, and...