A5061915282- Mechanical Circulatory Support Devices
- Cardiac Arrest and Resuscitation
- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Ultrasound in Clinical Applications
- Acute Myocardial Infarction Research
- Cardiac Structural Anomalies and Repair
- Vascular Procedures and Complications
- Cardiac, Anesthesia and Surgical Outcomes
- Sex and Gender in Healthcare
- Lipoproteins and Cardiovascular Health
- Optical Coherence Tomography Applications
- Pituitary Gland Disorders and Treatments
- Animal testing and alternatives
- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Central Venous Catheters and Hemodialysis
- Heart Failure Treatment and Management
- Hormonal Regulation and Hypertension
- Peripheral Artery Disease Management
- Adenosine and Purinergic Signaling
- Cardiovascular Issues in Pregnancy
- Molecular Biology Techniques and Applications
- Cardiac electrophysiology and arrhythmias
- Diversity and Career in Medicine
University of Ottawa
2016-2025
Ottawa Hospital
2024
Ottawa Hospital Research Institute
2024
Ottawa University
2022
Capital Group (United States)
2022
Ottawa Heart Institute
2018-2022
Society of Interventional Radiology
2022
University of Calgary
2019-2021
Icahn School of Medicine at Mount Sinai
2018
University of California, San Diego
2018
<h3>BACKGROUND:</h3> Radial artery access is commonly performed for coronary angiography and invasive hemodynamic monitoring. Despite limitations in diagnostic accuracy, the modified Allen test (manual occlusion of radial ulnar arteries followed by release latter assessment palmar blush) used routinely to evaluate collateral circulation hand and, therefore, determine patient eligibility access. We sought whether a smartphone application may provide superior alternative test....
Abstract Background Cardiogenic shock (CS) is associated with significant morbidity and mortality. The impact of beta-blocker (BB) use on patients who develop CS remains unknown. We sought to evaluate the clinical outcomes hemodynamic response profiles in treated BB 24 h prior development CS. Methods Patients enrolled DObutamine compaREd MIlrinone trial were analyzed. primary outcome was a composite all-cause mortality, resuscitated cardiac arrest, need for transplant or mechanical...
Background Adenosine is a ubiquitous regulatory molecule known to modulate signaling in many cells and processes vital vascular homeostasis. While studies of adenosine receptors have dominated research the field, quantification systemically locally remains limited owing largely technical restrictions. Given potential clinical implications biology, there need for adequately powered examining role plasma health. We sought describe analytical biological factors that affect humans large,...
Abstract Focused cardiac ultrasound (FoCUS) is becoming standard practice in a wide spectrum of clinical settings. There limited data evaluating the real-world use FoCUS with artificial intelligence (AI). Our objective was to determine accuracy AI-assisted left ventricular ejection fraction (LVEF) assessment and compare its between novice experienced users. In this prospective, multicentre study, participants requiring transthoracic echocardiogram (TTE) were recruited have done by or user....
Background The randomized DOREMI (Dobutamine Compared to Milrinone) clinical trial evaluated the efficacy and safety of milrinone dobutamine in patients with cardiogenic shock. Whether results remain consistent when stratified by acute myocardial infarction remains unknown. In this substudy, we sought evaluate differences management outcomes complicated shock (AMICS) versus non-AMICS. Methods Results Patients (n=192) were 1:1 or milrinone. primary composite end point subgroup analysis was...
BACKGROUND: It is unclear whether sex-based differences in cardiovascular outcomes exist late-onset hypertension. METHODS: This a population-based cohort study Ontario, Canada of 266 273 adults, aged ≥66 years with newly diagnosed We determined the incidence primary composite outcome (myocardial infarction, stroke, and congestive heart failure), all-cause mortality, death by sex using Cox proportional hazard models adjusted for demographic factors comorbidities. RESULTS: The mean age total...
Sex-based disparities in cardiovascular outcomes may be improved with appropriate hypertension management.
• In this analysis of 3,396 preclinical studies published in 5 leading cardiovascular journals over a 10-year period, women accounted for 24 ± 17% authors per manuscript. Female authorship is increasing science, but the proportions articles with first and senior different sex have remained unchanged, which suggests that segregation by mentorship relationships exists persists. reported animals used, female was positively associated studying animals, using both sexes, reporting sex-specific...
An individual's perceived need to improve their physical health (PNIPH) is an essential precursor adopting healthy behaviors. Nine potentially modifiable risk factors (PMRFs) for myocardial infarction collectively account ≥90% of the population attributable risk. Though widely recognized, impact on individuals' perceptions unclear.Residents from 6 provinces were administered a module changes as part 2011-2012 Canadian Community Health Survey, yielding relevant data 8 9 PMRFs sought. The...
Cardiogenic shock is associated with poor clinical outcomes. There a paucity of prospective data examining the efficacy and safety inotropic therapy in patients cardiogenic renal dysfunction. This study sought to examine treatment effect milrinone compared dobutamine relation function. In this post hoc analysis DOREMI (Milrinone as Compared Dobutamine Treatment Shock) trial, we examined outcomes after stratification based on baseline estimated glomerular filtration rate (eGFR) 60 ml/min/1.73...
Introduction and objective: Target lesion failure continues to limit the efficacy of percutaneous coronary intervention despite advancements in stent design medical therapy. Identification biomarkers risk stratify patients after has potential focus therapies on cohorts with increased benefits. Plasminogen activator inhibitor-1 been identified as a candidate biomarker. Herein, we evaluate biological variables which impact plasminogen levels analytical characteristics its utility biomarker...