A5062531425- Vascular Procedures and Complications
- Cardiac Arrest and Resuscitation
- Pancreatic function and diabetes
- Diabetes and associated disorders
- Acute Myocardial Infarction Research
- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Endoplasmic Reticulum Stress and Disease
- Coronary Interventions and Diagnostics
- Heart Failure Treatment and Management
- Central Venous Catheters and Hemodialysis
- Liver Disease Diagnosis and Treatment
- Venous Thromboembolism Diagnosis and Management
- Ultrasound in Clinical Applications
University of Ottawa
2018-2025
Ottawa Hospital
2018-2019
Ottawa Hospital Research Institute
2018-2019
It is unknown whether there a gene signature in pancreas which associated with type 1 diabetes (T1D). We performed partial pancreatectomies on 30-day preinsulitic, diabetes-prone BioBreeding (BBdp) rats to prospectively identify factors involved early prediabetes. Microarrays of the biopsies revealed downregulation endoplasmic reticulum (ER) stress, metabolism and apoptosis. Based these results, additional investigations compared expression control (BBc) BBdp age ~8, 30 60 days using...
Transradial access (TRA) has rapidly emerged as the preferred vascular site for coronary angiography and percutaneous intervention. Radial artery occlusion (RAO) remains an important complication of TRA it precludes future ipsilateral transradial procedures. While intraprocedural anticoagulation been studied extensively, definitive role postprocedural not yet established.The Rivaroxaban Post-Transradial Access Prevention Artery Occlusion trial is a multicentre, prospective, randomised,...
Abstract In a previous study we reported that prediabetic rats have unique gene signature was apparent even in neonates. Several of the changes observed, including enhanced expression pro-inflammatory genes and dysregulated UPR metabolism were first observed liver followed by pancreas. present investigated further early hepatic innate immunity two models type 1 diabetes (T1D), BBdp rat NOD mouse. There striking increase lipid deposits liver, particularly neonatal rats, with less but...
IntroductionType I myocardial infarction (T1MI) or Type II MI (T2MI) have different underlying mechanisms, however in the setting of cardiogenic shock (CS), it is not understood if patients experience resultantly outcomes. The objective this study was to determine clinical features, biomarker patterns, and outcomes these subgroups.MethodsPatients from CAPITAL-DOREMI trial presenting with acute (AMI) associated CS (n=103) where classified as T1MI (n=61) T2MI (n=42). primary endpoint a...