A5037471440- Mechanical Circulatory Support Devices
- Cardiac Arrest and Resuscitation
- Coronary Interventions and Diagnostics
- Acute Myocardial Infarction Research
- Cardiac Structural Anomalies and Repair
- Cardiac Imaging and Diagnostics
- Nuclear Materials and Properties
- Nuclear reactor physics and engineering
- Cardiac Valve Diseases and Treatments
- Vascular Procedures and Complications
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac, Anesthesia and Surgical Outcomes
- Heart Failure Treatment and Management
- Cardiac Arrhythmias and Treatments
- Ultrasound in Clinical Applications
- Atrial Fibrillation Management and Outcomes
- Cerebrovascular and Carotid Artery Diseases
- Lipoproteins and Cardiovascular Health
- Nuclear and radioactivity studies
- Venous Thromboembolism Diagnosis and Management
- Central Venous Catheters and Hemodialysis
- Nuclear Physics and Applications
- Sex and Gender in Healthcare
- Animal testing and alternatives
- Health Systems, Economic Evaluations, Quality of Life
University of Ottawa
2017-2025
Ottawa Hospital
2022-2024
Capital Group (United States)
2020-2022
Faculty (United Kingdom)
2021
Icahn School of Medicine at Mount Sinai
2018
University of California, San Diego
2018
Centre for Global Health Research
2017
Jungheinrich (Germany)
2012-2013
Royal College of Physicians of Edinburgh
2010
Agaplesion Markus Hospital
2001
Cardiogenic shock is associated with substantial morbidity and mortality. Although inotropic support a mainstay of medical therapy for cardiogenic shock, little evidence exists to guide the selection agents in clinical practice.
Cardiogenic shock secondary to acute myocardial infarction (AMI-CS) is associated with substantial short-term mortality; however, there are limited data on long-term outcomes and trends.This study sought examine of AMI-CS patients.This was a population-based, retrospective cohort in Ontario, Canada critically ill adult patients who were admitted hospitals between April 1, 2009 March 31, 2019. Outcome captured using linked health administrative databases.A total 9,789 consecutive from 135...
Background: Chronic activation of the innate immune system drives inflammation and contributes directly to atherosclerosis. We previously showed that macrophages in atherogenic plaque undergo RIPK3 (receptor-interacting serine/threonine-protein kinase 3)-MLKL (mixed lineage domain-like protein)–dependent programmed necroptosis response sterile ligands such as oxidized low-density lipoprotein damage-associated molecular patterns is active advanced atherosclerotic plaques. Upstream RIPK3-MLKL...
The aim of this study was to evaluate the outcome transcatheter mitral valve repair (TMVr) in patients with cardiogenic shock and significant regurgitation (MR). Patients severe MR have a poor prognosis setting conventional medical therapy. Because its favorable safety profile, TMVr is being increasingly used as an acute therapy population, though efficacy remains unknown. A multicenter, collaborative, patient-level analysis conducted. moderate (3+) or (4+) who were not surgical candidates...
Background Recent studies have shown improved outcomes in cardiogenic shock through protocols directed toward early identification and initiation of mechanical circulatory support. However, objective therapeutic targets-based on clinical and/or laboratory data-to guide real-time decision making are lacking. Lactate clearance has been suggested as a potential treatment target because its independent association with mortality. Methods Results In post hoc analysis the DOREMI (Dobutamine...
<h3>BACKGROUND:</h3> Radial artery access is commonly performed for coronary angiography and invasive hemodynamic monitoring. Despite limitations in diagnostic accuracy, the modified Allen test (manual occlusion of radial ulnar arteries followed by release latter assessment palmar blush) used routinely to evaluate collateral circulation hand and, therefore, determine patient eligibility access. We sought whether a smartphone application may provide superior alternative test....
Abstract Background Cardiogenic shock (CS) is associated with significant morbidity and mortality. The impact of beta-blocker (BB) use on patients who develop CS remains unknown. We sought to evaluate the clinical outcomes hemodynamic response profiles in treated BB 24 h prior development CS. Methods Patients enrolled DObutamine compaREd MIlrinone trial were analyzed. primary outcome was a composite all-cause mortality, resuscitated cardiac arrest, need for transplant or mechanical...
In light of the lack any prior systematic evaluations prevalence and types pain syndromes treatments found in patients with AIDS, a chart review study was undertaken to evaluate this issue. Fifty-two 96 charts reviewed (54%) had at least one note on nonprocedural or analgesic prescription. Although chest most prevalent location (22%), presumably because high incidence Pneumocystis carinii pneumonia, other possible AIDS-related entities, such as peripheral neuropathy thrombophlebitis, were...
Cardiogenic shock (CS) is a state of low cardiac output resulting in end-organ hypoperfusion. Despite high in-hospital mortality rates, little evidence exists regarding the optimal mean arterial pressure (MAP) target CS. We therefore evaluated relationship between achieved MAP and clinical outcomes patients with CS.We performed post hoc analysis CAPITAL DOREMI trial: randomized, double-blind trial comparing dobutamine to milrinone divided into group (average ≥ 70 mmHg over 36 h following...
Cardiogenic shock due to acute myocardial infarction (AMI-CS) is associated with significant short- and long-term morbidity mortality. Despite this, little known about cost.
Background Adenosine is a ubiquitous regulatory molecule known to modulate signaling in many cells and processes vital vascular homeostasis. While studies of adenosine receptors have dominated research the field, quantification systemically locally remains limited owing largely technical restrictions. Given potential clinical implications biology, there need for adequately powered examining role plasma health. We sought describe analytical biological factors that affect humans large,...
Abstract Focused cardiac ultrasound (FoCUS) is becoming standard practice in a wide spectrum of clinical settings. There limited data evaluating the real-world use FoCUS with artificial intelligence (AI). Our objective was to determine accuracy AI-assisted left ventricular ejection fraction (LVEF) assessment and compare its between novice experienced users. In this prospective, multicentre study, participants requiring transthoracic echocardiogram (TTE) were recruited have done by or user....