A5002193980- Coronary Interventions and Diagnostics
- Acute Myocardial Infarction Research
- Cardiac, Anesthesia and Surgical Outcomes
- Turbomachinery Performance and Optimization
- Antiplatelet Therapy and Cardiovascular Diseases
- Peripheral Artery Disease Management
- Cardiac Valve Diseases and Treatments
- Vascular Procedures and Complications
- Cardiac Imaging and Diagnostics
- Central Venous Catheters and Hemodialysis
- Pericarditis and Cardiac Tamponade
- Refrigeration and Air Conditioning Technologies
- Heat Transfer Mechanisms
- Cardiovascular Issues in Pregnancy
- Computational Fluid Dynamics and Aerodynamics
- 3D Printing in Biomedical Research
- Cardiac Arrhythmias and Treatments
- Fluid Dynamics and Turbulent Flows
- Optical Coherence Tomography Applications
- Infective Endocarditis Diagnosis and Management
- COVID-19 and healthcare impacts
- Cutaneous lymphoproliferative disorders research
- Spondyloarthritis Studies and Treatments
- Cardiac Arrest and Resuscitation
- Cardiovascular Function and Risk Factors
Prince of Wales Hospital
2016-2025
UNSW Sydney
2014-2025
Gosford Hospital
2024
Central Coast Local Health District
2024
Analysis Group (United States)
2024
University of Ottawa
2018-2023
Australian Centre for Heart Health
2022
Barts Health NHS Trust
2021
Port Macquarie Base Hospital
2017
Sutherland Hospital
2017
Background Adenosine is a ubiquitous regulatory molecule known to modulate signaling in many cells and processes vital vascular homeostasis. While studies of adenosine receptors have dominated research the field, quantification systemically locally remains limited owing largely technical restrictions. Given potential clinical implications biology, there need for adequately powered examining role plasma health. We sought describe analytical biological factors that affect humans large,...
BackgroundThe optimal strategy for large bore vascular closure following TAVR is a matter of contention as major bleeding and complications remain challenge. We compared three strategies post-TAVR in terms safety efficacy: dual ProGlide-based strategy, hybrid ProGlide Angio-Seal, MANTA strategy.MethodsPatients were enrolled one the strategies: two ProGlides, single with an 8 F or 18 MANTA.ResultsIn total, 172 patients this study: 86 group, 40 ProGlide/Angio-Seal 46 group. Hemostasis was...
The role of compound heterozygous genetic haemochromatosis (CHGH) (C282Y/H63D) mutations in the manifestations iron overload is known; however, extent these and their associated management remain unclear.This study evaluates phenotypic CHGH using laboratory radiological biomarkers including serum ferritin/transferrin saturation, liver function tests (LFT), thyroid tests, blood sugar level, abdominal ultrasound (US) or computed tomography. also effects venesection therapy on markers its...
ObjectiveTo ensure compliance with optimal secondary prevention strategies and document the residual risk of patients following revascularization, we established a postrevascularization clinic for risk-factor optimization at 1 year, outcomes recorded in web-based registry. Although coronary revascularization can reduce ischemia, medical treatment artery disease (CAD) remains cornerstone ongoing reduction. While standardized referral pathways protocols are prevalent well studied,...
Background: The 1.5mm ‘Baby J’ hydrophilic narrow J tipped wire is a development of the standard 0.035” 3mm peripheral guidewire, designed to improve efficiency transradial coronary procedures by safely navigating small caliber radial arteries aorta. There currently lack evidence comparing procedural success and safety different guidewires used in cardiac procedures. We compared efficacy (intervention - Radifocus™ TERUMO Co., Tokyo, Japan). versus fixed core (FC) (control). Methods:...
Abstract Background and Purpose The standard J tip peripheral guidewire used to perform coronary angiography was originally designed for transfemoral access large vascular interventions over 70 years ago. 3mm on the wire is larger than typical radial artery diameter has limited ability navigate smaller tortuous arteries increasing risk of vessel spasm, potentially reducing procedural success. We compared efficacy safety a hydrophilic 1.5mm (intervention - ‘baby wire’) upfront versus fixed...
Background Coronary revascularization using imaging guidance is rapidly becoming the standard of care. Intravascular optical coherence tomography uses near-infrared light to obtain high resolution intravascular images. Standard technique employs iodinated contrast dye achieve required blood clearance during acquisition. We sought systematically evaluate technical performance saline as an alternative for assessment. Methods and results performed bench top analysis on nylon tubing with...
Adenosine, a purine nucleoside, is produced broadly and implicated in the homeostasis of many cells tissues. It signals predominantly via 4 purinergic adenosine receptors (ADORs) - ADORA1, ADORA2A, ADORA2B ADOosine signaling, both through design as specific ADOR agonists antagonists offtarget effects existing anti-platelet medications. Despite this, has yet to be firmly established either therapeutic or prognostic tool clinical medicine date. Herein, we provide bench-to-bedside review...
A fan performance analysis method based upon three-dimensional steady Navier–Stokes equations is presented in this paper. Its accuracy established through extensive code validation effort. Validation data comparisons ranging from a two-dimensional compressor cascade to fans are shown paper highlight the and reliability of code. The overall design procedure using then presented. Typical results process for current engine design. This new introduces major improvement over conventional methods...
Clozapine-induced myopericarditis is a well-described adverse drug reaction. Clozapine also the most effi cacious agent in refractory schizophrenia. We report case of patient who was successfully re-trialled on clozapine two years after developing myopericarditis, which multiple lines alternative treatment failed. propose protocol for safely attempting re-trial such cases.
A three-dimensional inviscid time-marching calculation solving the unsteady Euler equations in a coordinate system rotating with blade row has been developed, based on Denton flow solver. This was used to compute field through rotor of transonic axial compressor and compared measurements made an advanced laser velocimeter at DFVLR. The comparison is design speed pressure ratio corresponding peak efficiency. Comparisons calculated experimentally determined Mach number contours indicate...
Stent thrombosis remains an infrequent but significant complication following percutaneous coronary intervention. Preclinical models to rapidly screen and validate therapeutic compounds for efficacy are lacking. Herein, we describe a reproducible, high throughput cost-effective method evaluate candidate therapeutics devices either treatment or propensity develop stent in vitro bench-top model. Increasing degree of malapposition (0.00 mm, 0.10 0.25 mm 0.50 mm) was associated with increasing...
The increasing demand for electric vehicles (EVs) presents significant challenges energy grids, particularly in balancing and supply during peak charging periods. This paper proposes an Adaptive Energy Management System (EMS) EV stations that leverages artificial intelligence (AI) techniques to optimize power distribution enhance grid stability. By integrating fuzzy logic reinforcement learning algorithms, the proposed system dynamically adjusts allocation based on real-time conditions...