Agnieszka Stadnik
A5067014628- Intracerebral and Subarachnoid Hemorrhage Research
- Vascular Malformations Diagnosis and Treatment
- Intracranial Aneurysms: Treatment and Complications
- Neurosurgical Procedures and Complications
- Acute Ischemic Stroke Management
- Cerebrospinal fluid and hydrocephalus
- MRI in cancer diagnosis
- Traumatic Brain Injury and Neurovascular Disturbances
- Glioma Diagnosis and Treatment
- Genetic diversity and population structure
- Extracellular vesicles in disease
- Genomics and Phylogenetic Studies
- Radiomics and Machine Learning in Medical Imaging
- Identification and Quantification in Food
- Brain Tumor Detection and Classification
- Advanced MRI Techniques and Applications
- Moyamoya disease diagnosis and treatment
- Diversity and Career in Medicine
- Spinal Hematomas and Complications
- Epigenetics and DNA Methylation
- Reproductive biology and impacts on aquatic species
- CNS Lymphoma Diagnosis and Treatment
- Global Health and Surgery
- Medical and Biological Ozone Research
- Medical Image Segmentation Techniques
University of Chicago
2016-2025
Neurological Surgery
2018-2025
Rosalind Franklin University of Medicine and Science
2023
University of Illinois Chicago
2019
Johns Hopkins University
2017-2019
Stanford University
2019
University of Cincinnati
2019
University of Cincinnati Medical Center
2019
University of New Mexico
2018-2019
University of Kansas
2019
Increases in mean lesional iron content by quantitative susceptibility mapping (QSM) ≥6% and/or vascular permeability dynamic contrast enhanced perfusion (DCEQP) ≥40% on MRI have been associated with new symptomatic hemorrhage (SH) cerebral cavernous malformations (CCMs). It is not known if plasma biomarkers can reflect these changes within the lesion proper. This cohort study enrolled 46 CCM patients SH prior year. Plasma samples, QSM and DCEQP were simultaneously acquired at beginning end...
Abstract BACKGROUND Minimally invasive surgery procedures, including stereotactic catheter aspiration and clearance of intracerebral hemorrhage (ICH) with recombinant tissue plasminogen activator hold a promise to improve outcome supratentorial brain hemorrhage, morbid disabling type stroke. A recently completed Phase III randomized trial showed improved mortality but was neutral on the primary (modified Rankin scale score 0 3 at 1 yr). OBJECTIVE To assess surgical performance its impact...
Arctic charr have a circumpolar distribution, persevere under extreme environmental conditions, and reach ages unknown to most other salmonids. The Salvelinus genus is primarily composed of species with genomes that are structured more like the ancestral salmonid genome than Oncorhynchus Salmo sister genera. It thought this aspect may be important for local adaptation (due increased recombination) anadromy (the migration fish from saltwater freshwater). In study, we describe generation new...
Abstract BACKGROUND More than a million Americans harbor cerebral cavernous angioma (CA), and those who suffer prior symptomatic hemorrhage have an exceptionally high rebleeding risk. Preclinical studies show that atorvastatin blunts CA lesion development through inhibiting RhoA kinase (ROCK), suggesting it may confer therapeutic benefit. OBJECTIVE To evaluate whether produces difference compared to placebo in lesional iron deposition as assessed by quantitative susceptibility mapping (QSM)...
The clinical course of cerebral cavernous malformations is highly unpredictable, with few cross-sectional studies correlating proinflammatory genotypes and plasma biomarkers prior disease severity.We hypothesize that a panel 24 candidate biomarkers, reported role in the physiopathology malformations, may predict subsequent clinically relevant activity.Plasma were assessed nonfasting peripheral venous blood collected from consecutive malformation subjects followed for 1 year after initial...
Abstract BACKGROUND Minimally invasive thrombolytic evacuation of intracerebral hematoma is being investigated in the ongoing phase III clinical trial Invasive Surgery plus recombinant Tissue plasminogen activator for Intracerebral hemorrhage Evacuation (MISTIE III). OBJECTIVE To assess accuracy catheter placement and efficacy relation to surgical approach surgeon experience. METHODS We performed a midpoint interim assessment 123 cases that underwent procedure. Accuracy was prospectively...
<h3>Objective:</h3> To investigate the temporal pattern and relevant associations of CSF inflammatory measures after intraventricular hemorrhage (IVH). <h3>Methods:</h3> We analyzed prospectively collected cell counts protein glucose levels from participants in Clot Lysis Evaluation Accelerated Resolution IVH phase III (CLEAR III) trial. Corrected leukocyte count index were calculated to adjust for leukocytes attributable circulating blood. Data chronologically plotted. (daily, mean, median,...
The extent of intracerebral hemorrhage (ICH) removal conferred survival and functional benefits in the minimally invasive surgery with thrombolysis evacuation (MISTIE) III trial. It is unclear whether this similarly impacts outcome craniotomy (open surgery) or timing from ictus to intervention influences either procedure.To compare volume relation outcomes MISTIE STICH (Surgical Trial Intracerebral Hemorrhage) trials.Postoperative scans were performed II, but not I; therefore, surgical cases...
Introduction and Hypothesis: New bleeding in cerebral cavernous malformations (CCM) heralds increased risk of future hemorrhage for several years, yet conventional imaging only detects new that occurred the prior weeks. A biomarker could help identifying high lesions. An increase mean lesional quantitative susceptibility mapping (QSM) ≥6% on MRI has been adjudicated as reflecting CCM during longitudinal follow-up. However, QSM from a single acquisition not diagnose or prognosticate bleed. We...
Introduction: Familial cerebral cavernous malformations (FCCM), Sturge-Weber Syndrome (SWS), and hereditary hemorrhagic telangiectasia with brain arteriovenous (HHT) are neurovascular disorders driven by genetic mutations while microbleeds (CMBs) primarily associated the aging process. All different vascular dysmorphisms and/or propensity to bleed. Hypothesis: We hypothesized that common distinct circulating microribonucleic acids (miRNAs), reflecting shared pathobiology, can serve as...
OBJECTIVE The American Association of Neurological Surgeons (AANS) and Congress (CNS) Section on Pediatric Surgery domestic traveling fellowship was created to cover the travel living expenses for a North neurosurgery resident 1 month at another institution gain experience in pediatric neurosurgery. objective this work guide future direction by surveying past recipients about its impact their training career. METHODS Historical data have been maintained AANS/CNS Executive Committee current...
Abstract BACKGROUND Brain cavernous angiomas with symptomatic hemorrhage (CASH) are uncommon but exact a heavy burden of neurological disability from recurrent bleeding, for which there is no proven therapy. Candidate drugs to stabilize the CASH lesion and prevent rebleeding will ultimately require testing safety efficacy in multisite clinical trials. Much progress has been made understanding epidemiology CASH, novel biomarkers have linked biological mechanisms activity lesions. Yet, ability...
BACKGROUNDCerebral cavernous angiomas (CAs) with a symptomatic hemorrhage (CASH) have high risk of recurrent and serious morbidity.METHODSEighteen plasma molecules mechanistic roles in CA pathobiology were investigated 114 patients 12 healthy subjects. The diagnostic biomarker CASH the prior year was derived as that minimizing Akaike information criterion validated using machine learning, compared prognostic predicting bleeding subsequent year. Biomarkers longitudinally followed subset...
Abstract Cavernous angiomas (CA) are common vascular anomalies causing brain hemorrhage. Based on mouse studies, roles of gram-negative bacteria and altered intestinal homeostasis have been implicated in CA pathogenesis, pilot study had suggested potential microbiome differences between non-CA individuals based 16S rRNA gene sequencing. We here assess a larger cohort human subjects with without CA, among different clinical features, conduct more definitive microbial analyses using...
Abstract Background: Cavernous angiomas (CAs) affect 0.5% of the population, predisposing to serious neurologic sequelae from brain bleeding. A leaky gut epithelium associated with a permissive microbiome, was identified in patients who develop CAs, favoring lipid polysaccharide producing bacterial species. Micro-ribonucleic acids along plasma levels proteins reflecting angiogenesis and inflammation were also previously correlated CA symptomatic hemorrhage. Methods: The metabolome hemorrhage...
Background Quantitative Susceptibility Mapping (QSM) MRI allows accurate assessment of iron content in cerebral cavernous malformations (CCM), and a threshold increase by 6% QSM has been shown to reflect new symptomatic hemorrhage (SH) previously stable lesions. Purpose/Hypothesis It is unclear how lesional evolves CCMs after recent SH, whether this could serve as monitoring biomarker clinical trials aimed at preventing rebleeding these Study Type This prospective observational cohort study....
Cerebral cavernous angioma (CA) is a capillary microangiopathy predisposing more than million Americans to premature risk of brain hemorrhage. CA with recent symptomatic hemorrhage (SH), most likely re-bleed serious clinical sequelae, the primary focus therapeutic development. Signaling aberrations in include proliferative dysangiogenesis, blood-brain barrier hyperpermeability, inflammatory/immune processes, and anticoagulant vascular domain. Plasma levels molecules reflecting these...
After this article [1] was published, further analysis revealed that the sample used for reported genome more likely from closely related species, Dolly Varden (Salvelinus malma), or may have been a hybrid between two species.We stand by and transcriptome assembly as scientifically valid representative of analyzed.However, identity individual is now in question consequently article's title, results, conclusions attributing sequences to Arctic charr are not upheld.In light issue, we retract...
Abstract Cerebral cavernous malformation (CCM) is a hemorrhagic neurovascular disease with no currently available therapeutics. Prior evidence suggests that different cell types may play role in CCM pathogenesis. The contribution of each type to the dysfunctional cellular crosstalk remains unclear. Herein, RNA-seq was performed on fluorescence-activated sorted endothelial cells (ECs), pericytes, and neuroglia from lesions non-lesional brain tissue controls. Differentially Expressed Gene...