A5080791677- Vascular Malformations Diagnosis and Treatment
- Intracerebral and Subarachnoid Hemorrhage Research
- Intracranial Aneurysms: Treatment and Complications
University of Chicago
2022-2025
Harbin Medical University
2023-2024
First Affiliated Hospital of Harbin Medical University
2023-2024
Neurological Surgery
2022-2024
BACKGROUND: Heterogeneity in the severity of cerebral cavernous malformations (CCMs) disease, including brain bleedings and thrombosis that cause neurological disabilities patients, suggests environmental, genetic, or biological factors act as disease modifiers. Still, underlying mechanisms are not entirely understood. Here, we report mild hypoxia accelerates CCM by promoting angiogenesis, neuroinflammation, vascular brains mouse models. METHODS: We used genetic studies, RNA sequencing,...
Introduction: Cerebral microbleeds (CMBs) are age-related manifestations of microangiopathies predisposing patients to hemorrhagic stroke (HS) and cognitive decline. Little work has currently been done elucidate mechanisms in the pathophysiology CMBs. Herein, we report transcriptomic signatures CMBs, as well important location/etiological sex-specific differences, glean mechanistic insights human autopsy tissue a murine E4FAD model. Methods: Fourteen CMB lesions were identified at by...
Abstract Background: Cavernous angiomas (CAs) affect 0.5% of the population, predisposing to serious neurologic sequelae from brain bleeding. A leaky gut epithelium associated with a permissive microbiome, was identified in patients who develop CAs, favoring lipid polysaccharide producing bacterial species. Micro-ribonucleic acids along plasma levels proteins reflecting angiogenesis and inflammation were also previously correlated CA symptomatic hemorrhage. Methods: The metabolome hemorrhage...
Abstract Cerebral cavernous malformation (CCM) is a hemorrhagic neurovascular disease with no currently available therapeutics. Prior evidence suggests that different cell types may play role in CCM pathogenesis. The contribution of each type to the dysfunctional cellular crosstalk remains unclear. Herein, RNA-seq was performed on fluorescence-activated sorted endothelial cells (ECs), pericytes, and neuroglia from lesions non-lesional brain tissue controls. Differentially Expressed Gene...