Shakeel A. Chowdhry
A5003602122- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Stroke Rehabilitation and Recovery
- Venous Thromboembolism Diagnosis and Management
- Intracranial Aneurysms: Treatment and Complications
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracerebral and Subarachnoid Hemorrhage Research
- Meningioma and schwannoma management
- Peripheral Artery Disease Management
- Vascular Malformations Diagnosis and Treatment
- Moyamoya disease diagnosis and treatment
- Cerebrospinal fluid and hydrocephalus
- History of Medical Practice
- Neurological Disorders and Treatments
- Spinal Fractures and Fixation Techniques
- Neurosurgical Procedures and Complications
- Protease and Inhibitor Mechanisms
- Retinal and Optic Conditions
- Fetal and Pediatric Neurological Disorders
- Head and Neck Surgical Oncology
- Signaling Pathways in Disease
- Ocular Diseases and Behçet’s Syndrome
- Trigeminal Neuralgia and Treatments
- Vascular Procedures and Complications
- Streptococcal Infections and Treatments
NorthShore University HealthSystem
2016-2025
Centro Hospitalar de Lisboa Central
2023
Glenbrook Hospital
2021
University of Chicago
2018-2020
Shaker Heights Public Library
2020
Stanford University
2019
University of Cincinnati
2019
University of Cincinnati Medical Center
2019
Johns Hopkins University
2019
University of Kansas
2019
Abstract BACKGROUND Minimally invasive surgery procedures, including stereotactic catheter aspiration and clearance of intracerebral hemorrhage (ICH) with recombinant tissue plasminogen activator hold a promise to improve outcome supratentorial brain hemorrhage, morbid disabling type stroke. A recently completed Phase III randomized trial showed improved mortality but was neutral on the primary (modified Rankin scale score 0 3 at 1 yr). OBJECTIVE To assess surgical performance its impact...
Recent clinical trials have shown that mechanical thrombectomy is superior to medical management for large vessel occlusion up 24 hours from onset. Our objective examine the safety and efficacy of beyond standard care window.A retrospective review was undertaken multicenter Stroke Thrombectomy Aneurysm Registry (STAR). We identified patients who underwent hours. selected a matched control group in 6-24-hour window. used functional independence at 3 months as our primary outcome measure.We...
Abstract BACKGROUND: Blister aneurysms of the internal carotid artery (ICA) are uncommon. There is a paucity data on long-term outcomes patients. OBJECTIVE: To review our experience with treatment these lesions. METHODS: We retrospectively reviewed all treated at institution between 1994 and 2005. Relevant operative notes, radiology reports, inpatient/outpatient records were reviewed. RESULTS: Seventeen patients (3 male, 14 female) 18 blister ICA identified. The mean age was 44.6 years...
Indocyanine green (ICG) angiography is commonly used to map the vascular configuration of cerebral arteriovenous malformations (AVMs) during resection.To determine whether ICG improves rates resection and clinical outcomes.A retrospective chart review was done for all patients undergoing an AVM by senior author (R.F.S.) between 2007 2011. Operative reports, hospital records, radiographic imaging were use ICG, incidence residual disease, total 130 cases (56 74 non-ICG) identified. Average...
Background Several studies have established the safety and efficacy of balloon guide catheters (BGCs) for large vessel occlusions. However, utility BGCs remains largely unexplored distal medium occlusions (DMVOs). In this study, we aim to compare outcomes BGC vs. Non-BGC in patients undergoing mechanical thrombectomy (MT) DMVO. Method This retrospective study from Stroke Thrombectomy Aneurysm Registry (STAR) encompassed adult with acute anterior cerebral artery, posterior middle...
Background The role for the transradial approach mechanical thrombectomy is controversial. We sought to compare and transfemoral in a large multicenter database of acute ischemic stroke. Methods prospectively maintained Stroke Thrombectomy Aneurysm Registry (STAR) was reviewed patients who underwent an internal carotid artery (ICA) or middle cerebral M1 occlusion. Multivariate regression analyses were performed assess outcomes including reperfusion time, symptomatic intracerebral hemorrhage...
Background The elderly population (≥80 years) were underrepresented in recent trials of endovascular thrombectomy (EVT) for anterior circulation large vessel occlusion acute ischemic stroke (LVO-AIS) with low Alberta Stroke Program Early CT Score (ASPECTS) (≤5). Methods This study analyzed data from a prospectively maintained database 37 centers. primary cohort the comprised patients LVO-AIS aged ≥80 who underwent EVT ASPECTS≤5 2013 to 2023. outcome was favorable modified Rankin Scale (mRS)...
Background The contact aspiration (CA) technique is often used to perform endovascular thrombectomy (EVT) for acute ischemic stroke (AIS); however, rescue strategies are necessary if CA fails achieve recanalization. This study investigates the outcomes of incorporating stent retriever (SR) in strategy following failed CA. Methods EVT patients with attempts were identified from a large multicenter registry and stratified by technique: alone or SR strategy. Outcomes included successful...
OBJECTIVE The definitive influence of prestroke disability on outcomes in patients with a low Alberta Stroke Program Early CT Score (ASPECTS) treated endovascular thrombectomy (EVT) for acute ischemic stroke (AIS) due to large-vessel occlusion (LVO) remains unknown. This study aimed investigate the impact this specific population. METHODS Data from 32 international centers AIS-LVO ASPECTS who underwent EVT between January 2013 and December 2022 were analyzed retrospectively. Low defined as...
INTRODUCTION: Recanalization of occluded intracranial large vessels after endovascular thrombectomy (EVT) is often achieved following multiple attempts. Current literature does not offer any guidance regarding switching to alternative techniques (AT) a futile first attempt. METHODS: We included patients with stroke secondary vessel occlusion (LVO) who failed their attempt at recanalization either ICA or M1 segments utilizing an international multicenter cohort. Propensity score matching was...
Deep-seated periventricular cavernous malformations of the basal ganglia or thalamus can be approached via an interhemispheric craniotomy.To determine surgical efficacy and clinical outcomes contralateral approach.Retrospective chart review was performed on patients undergoing approach for resection deep-seated malformation by senior author (R.F.S.) between 2005 2013. Demographic data were reviewed. Pre- postoperative imaging analyzed lesion location, size, associated venous anomaly,...
Background Recent clinical trials have demonstrated that patients with large vessel occlusion (LVO) and infarction core may still benefit from mechanical thrombectomy (MT). In this study, we evaluate outcomes of MT in LVO presenting extremely Alberta Stroke Program Early CT Score (ASPECTS 0–2). Methods Data the Thrombectomy Aneurysm Registry (STAR) was interrogated. We identified an intracranial internal carotid artery (ICA) or M1 segment middle cerebral A favorable outcome defined by...
The history and evolution of surgical strategies for the treatment Kleeblattschädel deformity are not well described in medical literature. anomaly is one most formidable craniosynostoses, requiring a multidisciplinary team treatment. initial descriptions this cloverleaf detailed present report. Two illustrative cases deformity, syndromic nonsyndromic craniosynostoses treated by senior authors, also along with insights into operative strategies.
ABBREVIATIONS BBB = blood-brain barrier; DHA docosahexaenoic acid; EPA eicosapentaenoic GCS Glasgow Coma Scale; ICP intracranial pressure; O3FA omega-3 polyunsaturated fatty TBI traumatic brain injury.
Background and Purpose Outcomes following mechanical thrombectomy (MT) are strongly correlated with successful recanalization, traditionally defined as modified Thrombolysis in Cerebral Infarction (mTICI) ≥2b. This retrospective cohort study aimed to compare the outcomes of patients low Alberta Stroke Program Early Computed Tomography Score (ASPECTS; 2–5) who achieved mTICI 2b versus those 2c/3 after MT.Methods utilized data from Thrombectomy Aneurysm Registry (STAR), which combined...
Background and purpose Endovascular treatment (EVT) has emerged as an alternative therapeutic strategy for the of intracranial fusiform aneurysms (IFAs), but little is known about safety efficacy deconstructive reconstructive methods, especially in patients presenting with subarachnoid hemorrhage (SAH). The this study to describe radiological clinical outcomes IFAs undergoing EVT. Methods A retrospective analysis was conducted 18 EVT IFAs, 13 whom (72.2%) presented SAH. Radiological were...
The therapeutic properties of plasminogen activators are dictated by their mechanism action. Unlike staphylokinase, a single domain protein, streptokinase, 3-domain (alpha, beta, and gamma) molecule, nonproteolytically activates human (h)-plasminogen protects plasmin from inactivation alpha(2)-antiplasmin. Because streptokinase-like was hypothesized to require the streptokinase gamma-domain, we examined action novel two-domain (alpha,beta) Streptococcus uberis activator (SUPA). Under...