A5036319128- Acute Ischemic Stroke Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Atrial Fibrillation Management and Outcomes
- Cerebrovascular and Carotid Artery Diseases
- Venous Thromboembolism Diagnosis and Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Stroke Rehabilitation and Recovery
- Blood Coagulation and Thrombosis Mechanisms
- Peripheral Artery Disease Management
- Pharmacological Effects and Assays
- Cardiac Arrhythmias and Treatments
- Intracranial Aneurysms: Treatment and Complications
- Pesticide Residue Analysis and Safety
- Facilities and Workplace Management
- Health Systems, Economic Evaluations, Quality of Life
- Antibiotics Pharmacokinetics and Efficacy
- Inhalation and Respiratory Drug Delivery
- Design Education and Practice
- Acute Myocardial Infarction Research
- Infection Control and Ventilation
- Parkinson's Disease and Spinal Disorders
- Innovation and Knowledge Management
- Urban Design and Spatial Analysis
- Housing, Finance, and Neoliberalism
Royal Prince Alfred Hospital
1995-2024
Ingham Institute
2011-2021
South Western Sydney Local Health District
2011-2020
UNSW Sydney
2010-2020
Neuroscience Research Australia
2019
University of Washington
2015
Manly Hospital
2011-2012
Sydney South West Area Health Service
2007-2012
Health Net
2012
Liverpool Hospital
2006-2011
<h3>Importance</h3> Intravenous thrombolysis with tenecteplase improves reperfusion prior to endovascular thrombectomy for ischemic stroke compared alteplase. <h3>Objective</h3> To determine whether 0.40 mg/kg of safely before vs 0.25 in patients large vessel occlusion stroke. <h3>Design, Setting, and Participants</h3> Randomized clinical trial at 27 hospitals Australia 1 New Zealand using open-label treatment blinded assessment radiological outcomes. Patients were enrolled from December...
Background and hypothesis Intravenous thrombolysis with alteplase remains standard care prior to thrombectomy for eligible patients within 4.5 h of ischemic stroke onset. However, only succeeds in reperfusing large vessel arterial occlusion a minority patients. We hypothesized that tenecteplase is non-inferior achieving reperfusion at initial angiogram, when administered onset, planned undergo endovascular therapy. Study design EXTEND-IA TNK an investigator-initiated, phase II, multicenter,...
Atrial fibrillation (AF) is increasing in prevalence and associated with significant morbidity mortality. The optimal diagnostic treatment strategies for AF are continually evolving care patients requires confidence integrating these new developments into practice. These clinical practice guidelines will assist Australian practitioners the diagnosis management of adult AF. Main recommendations: provide advice on standardised assessment atrial regarding: screening, prevention work-up; acute...
The incidence and natural history of large vessel occlusion (LVO) stroke in children is largely unknown. These knowledge gaps limit the uptake reperfusion therapies reduce efficiency pediatric acute pathways.To determine LVO stroke.This retrospective population-based cohort study was conducted between January 2010 December 2019, with a mean (SD) follow-up 37.0 (28.8) months. Admissions from all hospitals state New South Wales, Australia, final diagnosis arterial ischemic (AIS) patients 1...
Pediatric large vessel occlusion (LVO) stroke has a poor natural history. However, uptake of mechanical thrombectomy is hindered by lack clinical trial data in children. A randomized not feasible due to small sample sizes and absence equipoise.
In the past decade prevalence of atrial fibrillation (AF) has been increasing in ageing populations while stroke prevention and management have advanced. To inform clinician practice, health service planning further research, it is timely to reassess burden AF-related ischaemic stroke.We identified patients aged 18+ years with a primary or stay diagnosis (ICD-10-AM I63.x), from July 1, 2000 June 30, 2006, using an administrative dataset all hospitalisations New South Wales (population ∼7...
Background and purpose: Existing epidemiological studies of Myasthenia Gravis have generally examined small populations. Few national been conducted, published incidence prevalence rates vary widely. We report one the largest Gravis, first for Australia. Methods: Prescriptions Pyridostigmine Bromide in 2009 were utilized from a prescribing database to estimate symptomatic treated disease. Crude age‐standardized WHO world population. compared standardized recent Norway Taiwan. Results: In...
<h3>Background and Objectives</h3> Detailed study of tenecteplase (TNK) in patients older than 80 years is limited. The objective our was to assess the safety efficacy TNK at 0.25 0.40 mg/kg doses with large vessel occlusion. <h3>Methods</h3> We performed a pooled analysis EXTEND-IA randomized controlled trials (n = 502). Patients were adults presenting ischemic stroke due occlusion intracranial internal carotid, middle cerebral, or basilar artery within 4.5 hours symptom onset. compared...
There is a lack of modern-day data quantifying the effect transient ischemic attack (TIA) on survival, and recent do not take into account expected survival.Data for 22 157 adults hospitalized with TIA from July 1, 2000, to June 30, 2007, in New South Wales, Australia, were linked registered deaths 2009. We estimated survival relative age- sex-matched general population up 9-years after hospitalization comparing risk excess death between selected subgroups.At 1 year, 91.5% patients survived...
In randomized trials, acute stroke units are associated with improved patient outcomes. However, it is unclear whether this evidence can be successfully translated into routine clinical practice. We aimed to determine the effect of a coordinated rollout funding for 22 on outcomes in Australia.A multicenter observational study was undertaken using health administrative data recording admissions primary diagnosis ischemic from July 2000 June 2006. Analyses were stratified by hospital type...
SUMMARY Sulfaquinoxaline was administered orally to broilers, 4 6 weeks old, at a prophylactic dose level (0.025%) and laying hens cockerels therapeutic (0.05%). Sulfonamide residues were determined in muscle, liver, kidneys, skin, fat 0, 3, 5, 7 days post-treatment, as well eggs. Residue depletion most rapid between 0 3 after the drug withdrawn, with faster occurring muscle tissues. Residues persisted for longest time renal tissue. concentrations egg yolks still extremely high 5 withdrawal....
Background and Purpose: Subarachnoid haemorrhage (SAH) is associated with a high risk of mortality disability in survivors. We examined the epidemiology burden SAH our population during time services were re-organised to facilitate access evidence-based endovascular coiling neurosurgical care. Methods: hospitalisations from 2001 2009, New South Wales, Australia linked death registrations June 30, 2010. assessed variability admission rates, fatal rates case fatality over according patient...
Rationale Haematoma growth is common early after intracerebral haemorrhage (ICH), and a key determinant of outcome. Tranexamic acid, widely available antifibrinolytic agent with an excellent safety profile, may reduce haematoma growth. Methods design Stopping tranexamic acid for hyperacute onset presentation including mobile stroke units (STOP-MSU) phase II double-blind, randomised, placebo-controlled, multicentre, international investigator-led clinical trial, conducted within the estimand...
To evaluate engineering control measures to prevent nosocomial transmission of diseases such as tuberculosis, we studied four portable high-efficiency air filtration units, including three particulate (HEPA) for their ability remove aerosolized particles.Studies were conducted in either a nonventilated aerosol chamber or hospital isolation room that met CDC guidelines TB (negative pressure, > = 6 changes per hour, exhausted directly the outside). The rooms challenged with mineral oil size...
Objective: To compare outcomes at 28 days and 1 year between patients admitted to hospital those discharged after presenting the emergency department (ED) with transient ischaemic attack (TIA). Design setting: All TIA presentations EDs in a large metropolitan rural region of Sydney its surroundings, New South Wales, 2001 2005 were extracted from state health databases followed up over year. Admission discharge data subsequent or stroke identified. Main outcome measures: recurrence stroke....
<i>Background:</i> It is important to establish the validity of diagnostic coding in administrative datasets used stroke and transient ischemic attack (TIA) research. This study examines accuracy emergency department (ED) TIA diagnosis final after hospital admission. <i>Methods:</i> Using datasets, we identified all patients with an ED (435.9; ICD-9) admitted Liverpool Hospital from January 2003 December 2007. admission records were matched codes (ICD-10-AM) recorded....