A5103132337- Clinical Nutrition and Gastroenterology
- Nutrition and Health in Aging
- Sepsis Diagnosis and Treatment
- Intensive Care Unit Cognitive Disorders
- Nosocomial Infections in ICU
- Family and Patient Care in Intensive Care Units
- Hip and Femur Fractures
- Disaster Response and Management
- Gaze Tracking and Assistive Technology
- Traumatic Brain Injury and Neurovascular Disturbances
- EEG and Brain-Computer Interfaces
- COVID-19 and healthcare impacts
- Cardiac Arrest and Resuscitation
- Palliative Care and End-of-Life Issues
- Bacterial Identification and Susceptibility Testing
- Antimicrobial Resistance in Staphylococcus
- Respiratory Support and Mechanisms
- Climate Change and Health Impacts
- Neuroscience and Neural Engineering
- Child Nutrition and Feeding Issues
- Antibiotic Use and Resistance
- COVID-19 epidemiological studies
- Hemodynamic Monitoring and Therapy
- Allergic Rhinitis and Sensitization
- Trauma, Hemostasis, Coagulopathy, Resuscitation
The Royal Melbourne Hospital
2015-2025
The University of Melbourne
2016-2024
Clinical Trials New Zealand
2024
Melbourne Health
2014-2020
Murdoch Children's Research Institute
2003
<h3>Importance</h3> The Sepsis-3 Criteria emphasized the value of a change 2 or more points in Sequential [Sepsis-related] Organ Failure Assessment (SOFA) score, introduced quick SOFA (qSOFA), and removed systemic inflammatory response syndrome (SIRS) criteria from sepsis definition. <h3>Objective</h3> Externally validate assess discriminatory capacities an increase score by points, SIRS criteria, qSOFA for outcomes among patients who are critically ill with suspected infection. <h3>Design,...
BackgroundA multidisciplinary collaboration investigated the world's largest, most catastrophic epidemic thunderstorm asthma event that took place in Melbourne, Australia, on Nov 21, 2016, to inform mechanisms and preventive strategies.MethodsMeteorological airborne pollen data, satellite-derived vegetation index, ambulance callouts, emergency department presentations, data hospital admissions for as well leading up following were collected between March 31, 2017, analysed. We contacted...
Background Implantable brain–computer interfaces (BCIs), functioning as motor neuroprostheses, have the potential to restore voluntary impulses control digital devices and improve functional independence in patients with severe paralysis due brain, spinal cord, peripheral nerve or muscle dysfunction. However, reports date had limited clinical translation. Methods Two participants amyotrophic lateral sclerosis (ALS) underwent implant a single-arm, open-label, prospective, early feasibility...
Brain-computer interface (BCI) implants have previously required craniotomy to deliver penetrating or surface electrodes the brain. Whether a minimally invasive endovascular technique recording through jugular vein superior sagittal sinus is safe and feasible unknown.
Abstract Background International guidelines recommend greater protein delivery to critically ill patients than they currently receive. This pilot randomized clinical trial aimed determine whether a volume‐target enteral protocol with supplemental delivered amounts of and energy compared standard care. Methods Sixty participants received either the intervention (volume‐based protocol, supplementation) or nutrition care (hourly‐rate‐based without in intensive unit (ICU). Coprimary outcomes...
Objective: To determine the clinical and epidemiologic characteristics of patients with sepsis admitted to hospitals in Victoria, Australia, including incidence severe sepsis, utilization intensive care unit (ICU) resources, hospital mortality. Design: A population-based morbidity database generated from discharge coding. Setting: State Australia (population, 4.5 million), 4-yr period July 1, 1999, June 30, 2003. Patients: total 3,122,515 overnight hospitalizations. Interventions: None....
The response to the largest institutional outbreak of COVID-19 in health care workers Australia date needed be multidimensional In many countries, high rates with coronavirus disease 2019 (COVID-19) have been associated inadequate personal protective equipment (PPE), exposure large numbers patients COVID-19, worker fatigue, and limited access diagnostic testing.1-3 Australia, during initial phase epidemic, infections were largely attributable international travel, corroborated by genomically...
Hypophosphatemia occurs frequently. Enteral, rather than IV, phosphate replacement may reduce fluid replacement, cost, and waste.
Abstract Background Red blood cell (RBC) transfusion is associated with an increased risk of acute kidney injury (AKI). The extent to which RBC storage affects this association unclear. We aimed evaluate the between duration and occurrence or worsening any degree AKI in critically ill patients. Study Design Methods In pre‐planned sub‐study Standard Issue Transfusion versus Fresher Red‐Cell Use Intensive Care (TRANSFUSE) trial, compared mortality patients receiving either freshest available...
Abstract Background Functional recovery is an important outcome for those who survive critical illness. The present study aimed to assess nutrition provision and nutrition‐related outcomes in a multi‐trauma cohort following intensive care unit (ICU) discharge. Methods investigated prospective of patients discharged from ICU, had been admitted because major trauma required mechanical ventilation at least 48 h. Nutrition‐related outcomes, including body weight, quadriceps muscle layer...
Objective: Trials in critical care have previously used unvalidated systems to classify cause of death. We aimed provide initial validation a method death intensive unit patients. Design, setting and participants: One hundred case scenarios patients who died an ICU were presented online raters, asked select proximate underlying for each, using the Deaths Classifi cation Reason (ICU-DECLARE) system. evaluated two methods categorising (designated Lists A B) one Raters specialists research...
Abstract Background Patients who survive critical illness frequently develop muscle weakness that can impact on quality of life; nutrition is potentially a modifiable risk factor. The present study aimed to explore the associations between cumulative energy deficits (using indirect calorimetry and estimated requirements), nutritional functional outcomes. Methods A prospective single‐centre observational 60 intensive care unit ( ICU ) patients, were mechanically ventilated for at least 48 h,...
Current guidelines for the provision of protein critically ill patients are based on incomplete evidence, due to limited data from randomised controlled trials. The present pilot trial is part a program work expand knowledge about clinical effects delivery patients. primary aim this study determine whether an enteral feeding protocol using volume target, with additional supplementation, delivers greater amount and energy mechanically ventilated than standard nutrition protocol. secondary...
Adequate preparation and support for healthcare workers (HCWs) managing high-consequence infectious diseases (HCIDs) is critical to the overall clinical management of HCIDs. Qualitative studies examining how well prepared supported HCWs feel are lacking despite their key role. This study investigated front-line at an Australian tertiary hospital felt about HCIDs such as viral haemorrhagic fever (VHF).A qualitative research approach was used undertake interviews with 45 Royal Melbourne...
Objectives:To determine the impact of intensity early correction hyperglycaemia on outcomes in patients with diabetic ketoacidosis (DKA) admitted to intensive care unit. Methods:We studied adult DKA 171 ICUs Australia and New Zealand from 2000 2013. We used their blood glucose levels (BGLs) fi rst 24 hours after ICU admission whether hyperglycemia ≤180 mg/dL was independently associated hypoglycaemia, hypokalaemia, hypo-osmolarity or mortality, compared partial > 180 as recommended by...
Objective: To investigate the environmental precipitants, treatment and outcome of critically ill patients affected by largest most lethal reported epidemic thunderstorm asthma. Design, setting participants: Retrospective multicentre observational study. Meteorological, airborne particulate pollen data, a case series 35 admitted to 15 intensive care units (ICUs) due asthma event 21–22 November 2016, in Victoria, Australia, were analysed compared with 1062 total ICU-admitted Australian 2016....
Traumatic brain injury (TBI) can result in cerebral oedema and vascular changes resulting an increase intracranial pressure (ICP), which lead to further secondary damage. Decompressive craniectomy (DC) is a surgical option the management of ICP. We aimed investigate outcomes DC after TBI.We performed retrospective audit 57 adult patients (aged > 15 years) who underwent TBI, at Royal Melbourne Hospital from 1 January 2005 30 June 2011. Our functional outcome measure was Extended Glasgow...
In Australia, antimicrobial stewardship programmes are a compulsory component of hospital accreditation. Good documentation around anti-microbial prescribing aids communication and can improve practice in environments with multiple decision makers.This study aims to develop implement an intervention 24-bed intensive care unit tertiary referral adult hospital.We conducted four-phase (observation, reflection, implementation, evaluation) prospective collaborative before-after quality...