- Neuroscience of respiration and sleep
- Obstructive Sleep Apnea Research
- Non-Invasive Vital Sign Monitoring
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- Asthma and respiratory diseases
- Neonatal Respiratory Health Research
- Sleep and Wakefulness Research
- Neuroendocrine Tumor Research Advances
- Heart Rate Variability and Autonomic Control
- Engineering and Materials Science Studies
- Otolaryngology and Infectious Diseases
- Respiratory and Cough-Related Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Pancreatic and Hepatic Oncology Research
- EEG and Brain-Computer Interfaces
- Neonatal and fetal brain pathology
- Transition Metal Oxide Nanomaterials
- Drug-Induced Adverse Reactions
- Electrical and Bioimpedance Tomography
- Renal and Vascular Pathologies
- Food Allergy and Anaphylaxis Research
- Organ Donation and Transplantation
- Clinical Nutrition and Gastroenterology
- Inhalation and Respiratory Drug Delivery
The University of Melbourne
2024
The Royal Melbourne Hospital
2024
Can Tho University
2024
ResMed (Netherlands)
2024
University Medical Center HCMC
2021-2023
Viet Duc Hospital
2022
Vinh University
2021-2022
Woolcock Institute of Medical Research
2016-2021
The University of Sydney
2016-2021
Neuroscience Research Australia
2016-2018
Hypophosphatemia occurs frequently. Enteral, rather than IV, phosphate replacement may reduce fluid replacement, cost, and waste.
Background Telemonitoring trials for early detection of acute exacerbations chronic obstructive pulmonary disease (AECOPD) have provided mixed results. Day-to-day variations in lung function measured by the forced oscillation technique (FOT) may yield greater insight. We evaluated clinical utility home telemonitoring variability FOT measures terms 1) relationship with symptoms and quality life (QoL); 2) timing symptom changes prior to AECOPD. Methods Daily parameters at 5 Hz (resistance (R)...
Accurate breath detection is crucial in sleep and respiratory physiology research several clinical settings. However, this process technically challenging due to measurement physiological artifacts other factors such as variable leaks the breathing circuit. Recently developed techniques quantify multiple causes of obstructive apnea, require intermittent changes airway pressure applied a mask. This presents an additional unique challenge for detection. Traditional algorithms often drift...
To determine the effects of mild airflow limitation on K-complex frequency and morphology electroencephalogram (EEG) spectral power.
Pulmonary electrical impedance tomography (EIT) is a functional imaging technique that allows real-time monitoring of ventilation distribution. Ventilation heterogeneity (VH) characteristic feature chronic obstructive pulmonary disease (COPD) and has previously been quantified using features derived from tidal variations in the amplitude EIT signal. However, VH may be better described by time-based metrics, measurement which made possible high temporal resolution EIT. We aimed 1) to quantify...
Abstract Despite the decline in mortality rates of extremely preterm infants, intraventricular haemorrhage (IVH) remains common survivors. The need for resuscitation and cardiorespiratory management, particularly within first 24 hours life, are important factors incidence timing IVH. Variability analyses heart rate blood pressure data has demonstrated potential approaches to predictive monitoring. In this study, we investigated early identification infants at a high risk developing IVH,...
Methadone maintenance treatment (MMT) patients have a high prevalence of central sleep apnea and ataxic breathing related to damage respiratory rhythm control. However, the quantification indices requires laborious manual scoring, pattern is subjectively judged by visual recognition. This study proposes semi-automated technique characterize variability in MMT patients.
A negative intrathoracic pressure threshold is one commonly proposed mechanism for triggering respiratory-induced arousals in obstructive sleep apnea (OSA). If so, they should occur during inspiration, shortly after maximal swings. Alternatively, may throughout the respiratory cycle if other mechanisms also contribute. However, arousal timing has been minimally investigated. This study aimed to (1) determine temporal relationship between and breathing phase (2) characterize neuromuscular...
Recently, the concept of phase synchronization two weakly coupled oscillators has raised a great research interest and been applied to characterize phenomenon in physiological data. Phase cardiorespiratory coupling is often studied by synchrogram analysis, graphical tool investigating relationship between instantaneous phases signals. Although several techniques have proposed automatically quantify synchrogram, most them require preselection phase-locking ratio trial error. One technique...
Sighs are thought to have a role in regulating breathing control. They may preceed central apnea (sigh-CA) or pause (sigh-P), particularly quiet sleep. Recent techniques characterizing cardiorespiratory synchronization (CRS) provide sensitive measures of coupling, which is an important factor We speculated that the strength CRS and direction coupling (DC), would differ between sigh-P sigh-CA; before after sigh; with maturation.Prospective study. DC were calculated from respiratory signal...
Abstract Opioid‐related deaths from respiratory depression are increasing but there is only limited information on the effect of morphine breathing during sleep. This study aimed to detect and quantify opioid‐induced cardiorespiratory pattern changes sleep in obstructive apnea (OSA) patients using novel automated methods correlate these with conventional polysomnography (PSG) measures. Under a randomized double‐blind placebo‐controlled crossover design, 60 male OSA attended two one‐night...
Rationale: Poor adherence with asthma controller medication contributes to worse symptom control and increased exacerbation risk. Adherence is often expressed as the mean proportion of prescribed doses taken over a period 6–12 months. New metrics may capture individual day-to-day variability patterns linked distinct clinical outcomes. Objectives: To test hypotheses that novel time- dose-based offer independent value in identifying are associated (Asthma Control Test [ACT] score) risk, using...
Abstract Introduction Many factors impact CPAP adherence, some common issues include trouble falling asleep, difficulty breathing against pressure, and being disturbed by high pressures. Various settings to address comfort have been developed, such as ramp time, reducing pressure during exhalation, APAP response rate, though evidence of their is minimal. We sought develop a machine-learning model recommend personalised combinations at setup with the goal improving adherence in patients newly...
Background Transplant renal artery dissection (TRAD) is a rare and serious event that can cause allograft dysfunction eventually graft loss. Most cases are managed by operative repair. We report case of TRAD in the early postoperative period, which was successfully with intravascular ultrasound-assisted endovascular intervention. Case presentation A 38-year-old man underwent HLA-compatible living kidney transplantation. The had one vein, were anastomosed to internal iliac external...
BACKGROUND:Kounis syndrome is a hypersensitive coronary disorder triggered by drugs, food, and environmental factors. A 38-year-old male patient with acetaminophen-induced type 1 Kounis described. The purpose of this paper to show that serious condition may be linked common medication it should recognized earlier in clinical practice. CASE REPORT:We report case chest discomfort, dyspnea, hypotension following paracetamol continuous infusion, as well ST elevation on numerous leads during the...
<b>Background:</b> Telemonitoring studies to detect acute exacerbations of chronic obstructive pulmonary disease (AECOPD) early have mixed results. Day-to-day variations in lung function measured by forced oscillation technique (FOT) show promise asthma and might also be useful COPD. We assessed day-to-day FOT variability from home monitoring COPD its (i) relationship with symptoms quality life, (ii) timing changes relative symptom onset during AECOPD. <b>Methods:</b> For 8-9 months, we...
<b>Background:</b> Poor adherence with asthma preventer medication contributes to worse symptom control and increased exacerbation risk. Adherence is often expressed as the mean proportion of prescribed puffs taken over a period. New metrics may capture individual variability patterns linked distinct clinical outcomes. <b>Aims Objectives:</b> With electronically-recorded data from 6-month cluster randomised trial (Foster JM et al, 2014. JACI 134:1260-68), we examined novel metrics, their...
Despite the decline in mortality rates for extremely preterm infants, intraventricular haemorrhage (IVH) remains a threat to their survival. In this study, we sought explore logistic regression models predicting IVH as they would be applied clinical setting, using features derived from respiratory and blood pressure signals. Calculated predictors included mean (μ) short- long-term scaling exponents (α <sub xmlns:mml="http://www.w3.org/1998/Math/MathML"...
Introduction: Sighs (deep inspirations) are thought to have an important role in restoring lung volume, resetting the mechanical properties of tissue and neurorespiratory control. In quiet or non-rapid eye movement sleep, sighs often followed by post sigh central apnea. reduce frequency with maturation over first year life. We speculate that cardiorespiratory synchronization (CRS), as a measure control, would differ between without apnea, change maturation. also hypothesize infants chronic...
Recently, novel materials such as semiconductor metal oxide (SMO) nanowires (NWs), carbon nanotubes (CNTs), and hybrid SMO/CNTs have been attractively received attention for gas sensing applications. These are potential candidates improving the well known “3S”: Sensitivity, Selectivity Stability. In this article, we describe our recent studies on synthesis characterizations of nanomaterials gas-sensing The focused topics include are: (i) various system made CNTs SMO; (ii) quasi-one-dimension...
Introduction Significant advances have been made in the diagnosis and treatment of coronary artery disease over years. New generations scaffolds containing novel material eluting drug produced one most significant advancements intervention. The newest generation would be Magmaris with a magnesium frame sirolimus cover. Methods From July 2018 to August 2020, 58 patients treated at University Medical Center Ho Chi Minh City were enrolled this study. Results A total 60 lesions stented, 60.3%...