A5006943251- Cancer Immunotherapy and Biomarkers
- Neuroscience and Neuropharmacology Research
- Cardiac tumors and thrombi
- Cellular transport and secretion
- Liver Disease and Transplantation
- Infective Endocarditis Diagnosis and Management
- Lipid Membrane Structure and Behavior
- Peptidase Inhibition and Analysis
- Pericarditis and Cardiac Tamponade
- Brain Metastases and Treatment
- Transplantation: Methods and Outcomes
- Infectious Aortic and Vascular Conditions
- Retinal Development and Disorders
- COVID-19 and healthcare impacts
- Liver Disease Diagnosis and Treatment
- Cardiac Structural Anomalies and Repair
- Parkinson's Disease Mechanisms and Treatments
- Organ Transplantation Techniques and Outcomes
- Colorectal Cancer Treatments and Studies
- Vasculitis and related conditions
- Folate and B Vitamins Research
- Gun Ownership and Violence Research
- Disaster Response and Management
- Aldose Reductase and Taurine
- Myasthenia Gravis and Thymoma
MedStar Georgetown University Hospital
2024
Georgetown University
2020-2024
MedStar Health
2024
Cleveland Clinic
2024
Meredith College
2023
MedStar Washington Hospital Center
2021
University at Buffalo, State University of New York
2021
University of Michigan
2016-2020
Wayne State University
2016
Neural networks engaged in high-frequency activity rely on sustained synaptic vesicle recycling and coordinated recruitment from functionally distinct (SV) pools. However, the molecular pathways matching neural to SV dynamics release requirements remain unclear. Here we identify unique roles of SNARE-binding Tomosyn1 (Tomo1) proteins as activity-dependent substrates that regulate pool partitioning at rat hippocampal synapses. Our analysis is based monitoring changes defined pools via...
Members of the Rab3 gene family are considered central to membrane trafficking synaptic vesicles at mammalian excitatory synapses. Recent evidence, however, indicates that Rab27B-GTPase, which is highly homologous family, also enriched on SV membranes and co-localize with Rab3A Synaptotagmin presynaptic terminals. While functional roles have been well-established, little information exists role Rab27B in transmission. Here we report effects SC-CA1 DG-MF hippocampal The data establish...
Clinical Presentation: A 52-year-old female with metastatic Stage IVB (T4N3M1c) lung adenocarcinoma presented worsening dyspnea. She had just completed her 3 rd round of carboplatin/pemetrexed/pembrolizumab/MK-5890 chemotherapy. Upon examination she was noted to be hypertensive and tachycardic an elevated high-sensitivity troponin T. ECG showed sinus tachycardia, left axis deviation, flattened T waves in lead V5 V6. In the ED, subsequently developed supraventricular tachycardia admitted ICU....