A5034627659- Radiopharmaceutical Chemistry and Applications
- Atherosclerosis and Cardiovascular Diseases
- Cardiovascular Disease and Adiposity
- Spectroscopy and Quantum Chemical Studies
- Protein Structure and Dynamics
- Mass Spectrometry Techniques and Applications
- Monoclonal and Polyclonal Antibodies Research
- Microfluidic and Capillary Electrophoresis Applications
- Cardiac Structural Anomalies and Repair
- Biomarkers in Disease Mechanisms
- Cancer Immunotherapy and Biomarkers
- Peptidase Inhibition and Analysis
- Natural Antidiabetic Agents Studies
- Plant Stress Responses and Tolerance
- Cardiomyopathy and Myosin Studies
- Microencapsulation and Drying Processes
- Proteins in Food Systems
- Obsessive-Compulsive Spectrum Disorders
- Microfluidic and Bio-sensing Technologies
- Metabolism, Diabetes, and Cancer
- Drug Solubulity and Delivery Systems
- Botanical Research and Applications
- Angiogenesis and VEGF in Cancer
- Cardiac tumors and thrombi
- Medical Imaging and Pathology Studies
MedStar Georgetown University Hospital
2023-2024
Georgetown University
2023-2024
MedStar Health
2024
Cleveland Clinic
2024
MedStar Washington Hospital Center
2024
Actinium Pharmaceuticals (United States)
2022-2023
University of Virginia
1994-2022
Erlanger Health System
2022
Iowa State University
2017
Virginia Tech
2014
The effects of leaf developmental age on the expression three nuclear gene families in pea (Pisum sativum L.) coding for enzymes chlorophyll and heme biosynthesis have been examined. steady-state levels mRNAs encoding aminolevulinic acid (ALA) dehydratase, porphobilinogen (PBG) deaminase, NADPH:protochlorophyllide reductase were measured by RNA gel blot quantitative slot-blot analyses foliar leaves embryos that had imbibed 12 to 18 h developing seedlings grown either total darkness or under...
The objective of this study was to examine the influence intra- and extragranular microcrystalline cellulose (MCC) on drug dissolution from tablets made by high-shear granulation. Granulations were in a Littleford Model W-10-B (10-liter) mixer dried fluid bed dryer (Niro Inc.). A Plackett-Burman screening design 23 factorial employed how type, MCC (intra- or extra-), filler type (lactose dicalcium phosphate), disintegrant (sodium starch glycolate croscarmellose sodium) level, proportion...
Highly flexible proteins present a special challenge for structure determination because they are multi-structured yet not disordered, so their conformational ensembles essential understanding function. Because spectroscopic measurements of multiple populations often provide sparse data, experiment selection is limiting factor in refinement. A molecular simulations- and information-theory based approach to select which experiments best refine has been developed. This was tested on three...
Objective: Positron emission tomography (PET) imaging is a powerful non-invasive method to determine the in vivo behavior of biomolecules. Determining biodistribution and pharmacokinetic (PK) properties targeted therapeutics can enable better understanding drug mechanisms such as tumor uptake, off target accumulation clearance. Zirconium-89 (89Zr) readily available tetravalent PET-enabling radiometal that has been used evaluate PK monoclonal antibodies. In current study, we performed vitro...
Animal models are essential for developing effective drugs treating human cancer. Examination of the formation lung surface foci B16-F10 melanoma cells is a widely used animal model studying cancer metastasis and drug intervention. This model, however, suffers from several drawbacks, including its non-quantitative nature inability to yield information on cell load inside target organ. Here we report development highly sensitive, bioluminescence-based method quantifying in mouse lungs...
Abstract Background: HER3 is a unique member of the EGFR family that collaborates with other receptors to induce tumorigenesis and drug resistance. Moreover, expression linked poor survival for patients solid tumors. Despite being rational cancer therapeutic target, no HER3-directed therapies have been approved clinical use. However, new strategies such as antibody conjugates (ADCs) are investigated. Targeted radiotherapy, including radiolabeled antibodies (ARCs), mechanistically by inducing...
Abstract Highly flexible proteins present a special challenge for structure determination because they are multi‐structured yet not disordered, so their conformational ensembles essential understanding function. Because spectroscopic measurements of multiple populations often provide sparse data, experiment selection is limiting factor in refinement. A molecular simulations‐ and information‐theory based approach to select which experiments best refine has been developed. This was tested on...
We present a case of post-myocardial infarction free-wall rupture in critically ill patient presenting to the emergency department. Through our we highlight prompt evaluation, diagnosis, and management necessary improve survival with this life-threatening condition. (Level Difficulty: Beginner.).