A5009387699- Drug Solubulity and Delivery Systems
- Analytical Methods in Pharmaceuticals
- Pharmaceutical studies and practices
- Advanced Drug Delivery Systems
- Antibiotics Pharmacokinetics and Efficacy
- Crystallization and Solubility Studies
- Analytical Chemistry and Chromatography
- Powder Metallurgy Techniques and Materials
- Polymer Science and PVC
- Neurotransmitter Receptor Influence on Behavior
- Food Science and Nutritional Studies
- Surfactants and Colloidal Systems
- Attention Deficit Hyperactivity Disorder
- Medical Device Sterilization and Disinfection
- Blood disorders and treatments
- Asphalt Pavement Performance Evaluation
- Anesthesia and Sedative Agents
- Advanced Statistical Process Monitoring
- Analytical Chemistry and Sensors
- Polysaccharides Composition and Applications
- Advancements in Transdermal Drug Delivery
- Polymer Nanocomposites and Properties
University of Maryland, Baltimore
1995-1999
MCPHS University
1989-1995
The purpose of this investigation was to examine the impact formulation and process changes on dissolution bioavailability/bioequivalency metoprolol tartrate tablets manufactured using a high-shear granulation process. A half-factorial (24-1, Res TV) design undertaken study selected processing variables during scale-up. Levels ranges for excipients studied represented level 2 or greater as indicated by SUPAC-IR Guidance. Blend tableting properties were evaluated. Changes in sodium starch...
The main objective of this study was to investigate the release kinetics and mechanism involved in transport an ionizable drug through polymeric films applied drug-loaded beads. influence factors such as loading membrane thickness on were also investigated. Beads containing propranolol hydrochloride coated with either two commercially available aqueous dispersions, Aquacoat® or Sure lease®, using Wurster-Process. Analysis data suggest that followed zero-order kinetics. plots constants versus...
The purpose of this study was to evaluate the effect formulation and processing changes on dissolution bioavailability propranolol hydrochloride tablets. Directly compressed blends 6 kg (20,000 units) were prepared by mixing in a 16-qt V blender tablets an instrumented Manesty D3B tablet press. A half-factorial (25–1, Resolution V) design used following variables: filler ratio (lactose/dicalcium phosphate), sodium starch glycolate level, magnesium stearate lubricant blend time, compression...
The objective of this study was to examine the influence intra- and extragranular microcrystalline cellulose (MCC) on drug dissolution from tablets made by high-shear granulation. Granulations were in a Littleford Model W-10-B (10-liter) mixer dried fluid bed dryer (Niro Inc.). A Plackett-Burman screening design 23 factorial employed how type, MCC (intra- or extra-), filler type (lactose dicalcium phosphate), disintegrant (sodium starch glycolate croscarmellose sodium) level, proportion...
Abstract Purpose —The objective of this study was to evaluate the in vitro dissolution and vivo absorption D , L ‐ threo ‐methylphenidate (MPH) from a novel bimodal release formulation (Ritalin ® LA capsule) compared with an immediate‐release IR tablet) healthy volunteers. Methods contains 50% dose (IR) beads polymethacrylate‐coated, delayed‐release (DR) beads. To better understand impact DR on oral MPH, three Ritalin formulations different profiles for (referred as slow‐, medium...
Abstract The influence of formulation and extrinsic factors has been investigated for the in-vitro release propranolol hydrochloride from controlled-release beads prepared using aqueous polymeric dispersions, Aquacoat Surelease. A single-dose three-way crossover bioavailability study two extended-release experimental formulations (80 mg), Inderal LA mg) an immediate-release dosage form (2 × 40 was also conducted a comparative analysis pharmacokinetic parameters profiles performed to assess...
AbstractTablets containing sodium salicylate were prepared by direct compression and coated with ethylcellulose polyethylene glycol 3350. The effect of drug loading, carrier type, polymer ratio in the coating solution, pH dissolution medium, agitation speed on release investigated using USP XXI paddle method. It was observed that carriers, ethyl cellulose to glycol, amount present tablet, used did not have any influence from tablets, while medium (gastric vs. intestinal fluids) found affect release.