A5009324442- Viral Infections and Immunology Research
- Advanced MRI Techniques and Applications
- Lymphatic System and Diseases
- Cardiac tumors and thrombi
- Cardiac Imaging and Diagnostics
- Sympathectomy and Hyperhidrosis Treatments
- SARS-CoV-2 and COVID-19 Research
- HIV, Drug Use, Sexual Risk
- Syphilis Diagnosis and Treatment
- Peripheral Neuropathies and Disorders
- Axon Guidance and Neuronal Signaling
- Psychosomatic Disorders and Their Treatments
- Insect and Pesticide Research
- Stroke Rehabilitation and Recovery
- Cytokine Signaling Pathways and Interactions
- Acute Ischemic Stroke Management
- Suicide and Self-Harm Studies
- Medical Imaging Techniques and Applications
- Cardiac Arrhythmias and Treatments
- Inflammatory Myopathies and Dermatomyositis
- Brain Metastases and Treatment
- Autophagy in Disease and Therapy
- Neurological Disorders and Treatments
- Reproductive tract infections research
- Angiogenesis and VEGF in Cancer
MedStar Heart & Vascular Institute
2024
Cleveland Clinic
2023
MedStar Georgetown University Hospital
2023
Georgetown University
2023
MedStar Washington Hospital Center
2023
Northwestern University
2014-2022
Northwestern Memorial Hospital
2020
University of Alabama at Birmingham
2017
Birmingham–Southern College
2017
The lymphatic vasculature is essential for maintaining interstitial fluid homeostasis, and dysfunctional lymphangiogenesis contributes to various pathological processes, including inflammatory disease tumor metastasis. Mutations in FOXC2 are dominantly associated with late-onset lymphedema; however, the precise role of a closely related factor, FOXC1, system remains largely unknown. Here we identified molecular cascade by which FOXC1 regulate ERK signaling vessel growth. In mice, endothelial...
BACKGROUND: The transmembrane receptor Notch1 is a critical regulator of arterial differentiation and blood vessel sprouting. Recent evidence shows that functional blockade its ligand, Dll4, leads to postnatal lymphatic defects in mice. However, the precise role Notch signaling pathway development has yet be defined. Here we show developmental vascular morphogenesis by analyzing endothelial cell (LEC)‐specific conditional knockout mice crossed with an inducible Prox1CreER T2 driver. RESULTS:...
The yeast vacuole plays key roles in cellular stress responses. Here, we show that deletion of lvs1, the fission homolog Chediak-Higashi Syndrome CHS1/LYST gene, increases vacuolar size, similar to Rab4 ypt4. Overexpression lvs1-YFP rescued size ypt4Δ cells, but ypt4-YFP did not rescue lvs1Δ, suggesting lvs1 may act downstream Vacuoles were capable hypotonic shock-induced fusion and recovery both lvs1Δ although be slightly delayed ypt4Δ. Endocytic secretory trafficking affected, strains...
Giant cell myocarditis (GCM) and cardiac sarcoidosis share clinical histologic features, but whether they represent separate processes or lie on an inflammatory cardiomyopathy spectrum is unclear. We present a case of cardiogenic shock thought to be secondary biopsy-proven GCM with subsequent post-transplant diagnosis through 18-fluorodeoxyglucose positron emission tomography biopsy.
Clinical Presentation: A 52-year-old female with metastatic Stage IVB (T4N3M1c) lung adenocarcinoma presented worsening dyspnea. She had just completed her 3 rd round of carboplatin/pemetrexed/pembrolizumab/MK-5890 chemotherapy. Upon examination she was noted to be hypertensive and tachycardic an elevated high-sensitivity troponin T. ECG showed sinus tachycardia, left axis deviation, flattened T waves in lead V5 V6. In the ED, subsequently developed supraventricular tachycardia admitted ICU....
Purpose To develop and evaluate a flexible, Bloch‐equation based framework for retrospective correction to the arterial input function (AIF) obtained with quantitative cardiac perfusion pulse sequences. Methods Our initially calculates gadolinium concentration [Gd] on T 1 measurements alone. Next, is estimated from this initial calculation of while assuming fast water exchange using literature native 2 static magnetic field variation (ΔB 0 ) values. Finally, recalculated after performing...
<h3>Introduction</h3> STI testing is too often separated from HIV services and thus persons who may be at risk for are not adequately screening infection. Data suggest that current infection an indicator of elevated over a short period time (e.g. 3 months). Therefore, detecting important to both treatment management risk-reduction. <h3>Methods</h3> In October 2015 we began offering Birmingham AIDS Outreach, CBO that, among other activities, offers testing, counselling prevention services....
Introduction: Chest pain is common in patients with Post-acute Sequelae of SARS-CoV-2 (PASC), also known as long COVID, but the mechanism unknown. Hypothesis: We hypothesized that PASC chest have impaired myocardial perfusion reserve (MPR) measured by stress cardiovascular magnetic resonance (CMR) imaging. Methods: retrospectively identified first 30 consecutive who underwent clinically ordered adenosine CMR for persisting >4 weeks after infection (PASC). Patients a history coronary...