A5070642310- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Venous Thromboembolism Diagnosis and Management
- Chemotherapy-induced cardiotoxicity and mitigation
- Cardiovascular Syncope and Autonomic Disorders
- ECG Monitoring and Analysis
- Takotsubo Cardiomyopathy and Associated Phenomena
- Silicon Carbide Semiconductor Technologies
- HER2/EGFR in Cancer Research
- Cardiac tumors and thrombi
- Public Administration and Political Analysis
- Microbial Inactivation Methods
- Electrostatic Discharge in Electronics
- Parkinson's Disease and Spinal Disorders
- Receptor Mechanisms and Signaling
- Cardiomyopathy and Myosin Studies
- Toxin Mechanisms and Immunotoxins
- Heart Failure Treatment and Management
- Cancer Treatment and Pharmacology
- Optical Coherence Tomography Applications
- Pericarditis and Cardiac Tamponade
- Cardiac Structural Anomalies and Repair
- Cardiovascular Effects of Exercise
Mita Hospital
2022-2024
International University of Health and Welfare
2021-2022
Mount Sinai Hospital
2022
Icahn School of Medicine at Mount Sinai
2017-2022
Foundation of Cardiac Surgery Development
2022
Tsuchiura Kyodo General Hospital
2014-2017
Tokyo Medical and Dental University
2016-2017
Mount Sinai Medical Center
2017
Mount Sinai Hospital
2016
Abbott (Sweden)
2015
Background: Pulsed field ablation (PFA) is a uniquely tissue-selective, nonthermal cardiac modality. Delivery parameters such as the electrical waveform composition and device design are critical to PFA’s efficacy safety, particularly tissue specificity. In series of preclinical studies, we sought examine electrophysiological histological effects PFA compare safety feasibility durable pulmonary vein superior vena cava (SVC) isolation between radiofrequency waveforms. Methods: A femoral...
Pulsed field ablation (PFA) is a novel, non-thermal modality that selectively ablates myocardium with ultra-short electrical impulses while sparing collateral tissues. In proof-of-concept study, the safety and feasibility of ventricular PFA were assessed using prototype steerable, endocardial catheter.
The post-second-generation cryoballoon (CB) ablation isolation area during the chronic phase has not been described. aim of this study was to quantitatively evaluate chronic-phase after 28-mm second-generation CB and compare it estimated conventional radiofrequency circumferential pulmonary vein (CPVI) line.Thirty-two patients with paroxysmal atrial fibrillation underwent (PV) using CB. After a median 6.0 (4.0-9.0) months, PV evaluated high-resolution mapping (1-mm electrode, 2-mm...
Although percutaneous left ventricular assist devices (pLVADs) facilitate mapping and ablation of hemodynamically unstable tachycardia (VT), there is limited data whether clinical outcomes are improved. We sought to retrospectively compare the patients undergoing scar-related VT with without pLVAD support.The study population comprised 194 (109 85 non-pLVAD). The group more often had dilated cardiomyopathy (33% versus 13%; P=0.001), New York Heart Association heart failure class ≥III (51%...
Atrial fibrillation is a clinically important arrhythmia. There are some reports on machine learning models for AF diagnosis using electrocardiogram data. However, few have proposed an eXplainable Artificial Intelligence (XAI) model to enable physicians easily understand the model's results.
Inflammation plays a prominent role in the etiology of early recurrence atrial fibrillation (ERAF). We prospectively compared proportion ERAF and time-course patterns biomarkers between radiofrequency (RF) cryoballoon (CB) ablation.We enrolled 82 consecutive paroxysmal AF patients undergoing pulmonary vein (PV) isolation, performed with either 28-mm 2nd-generation CB 3-min freeze technique or point-by-point RF ablation. Each group had 41 patients. In group, all PVs were successfully isolated...
Esophagus‐Related Complications After Cryoablation Background Monitoring luminal esophageal temperatures (LETs) helps predict thermal lesions (ETLs) after catheter ablation. This study aimed to evaluate esophagus‐related complications second‐generation cryoballoon ablation under simultaneous LETs monitoring from 2 probes. Methods Forty consecutive paroxysmal atrial fibrillation patients undergoing conscious sedation followed by esophagogastroscopy were prospectively included. Two temperature...
Periesophageal vagal nerve injury is recognized as a rare complication in atrial fibrillation ablation procedures. We investigated the factors associated with occurrence of symptomatic periesophageal after pulmonary vein antrum isolation.Overall, 535 consecutive patients who underwent sole isolation were included. Point-by-point radiofrequency applications applied using irrigated-tip catheters under minimal sedation without esophageal temperature monitoring. In initial 165 patients, settings...
Bilateral Diaphragmatic CMAPs During Cryoablation Background Left phrenic nerve injury (PNI) can occur during cryoballoon ablation of the left pulmonary veins (PVs). This study aimed to evaluate feasibility monitoring bilateral function atrial fibrillation (AF). Methods Fifty consecutive paroxysmal AF patients undergoing using one 28‐mm second‐generation balloon were prospectively enrolled. diaphragmatic compound motor action potentials (CMAPs) obtained from modified surface electrodes by...
Atrial fibrillation ablation is associated with substantial risks of silent cerebral events (SCEs) or lesions. We investigated which procedural processes during cryoballoon procedures carried a risk.Forty paroxysmal atrial patients underwent pulmonary vein isolation using second-generation cryoballoons single 28-mm balloon 3-minute freeze techniques. Microembolic signals (MESs) were monitored by transcranial Doppler throughout all procedures. Brain magnetic resonance imaging was obtained...
Background:Early recurrence of atrial fibrillation (ERAF) is common after pulmonary vein antrum isolation (PVAI); however, the definition, study population, and lesion set are not uniform in prior studies. We examined ERAF for paroxysmal AF while complying with definition latest guidelines.Methods Results:We included 471 patients undergoing empirical PVAI AF. was observed 180 (38.2%) including 49, 16, 115 within 3, 4–7 days, 8–90 respectively, index procedure. (hazard ratio 6.872; 95%...
Clinical outcomes after atrial fibrillation (AF) ablation are evaluated using standard 24-h Holter monitoring, and the large spontaneous variability of AF episodes incidence silent major limitations. Further, symptoms generally decrease ablation. METHODS AND RESULTS: Newly developed extended external auto-trigger loop recorders (ELR) were used for 14-day consecutive monitoring to detect tachyarrhythmia (ATa). Continuous tracings stored initial 24h. Among 500 examinations in 342 patients, 40...
Impact of Cryoballoon Ablation on SVC Potentials Background Radiofrequency ablation the right superior pulmonary vein (RSPV) can lead to inadvertent vena cava (SVC) isolation due close anatomical proximity. This study aimed evaluate impact PV potentials with a second‐generation cryoballoon. Methods Thirty‐one consecutive paroxysmal atrial fibrillation patients who underwent exclusively 28 mm cryoballoon and single 3‐minute freeze technique were prospectively enrolled. The produced potential...
The mini electrodes (ME) placed on the tip of ablation electrode provide more precise local signal. We evaluated whether ME catheter was effective for cavotricuspid isthmus (CTI)-dependent atrial flutter. Eighty-five consecutive patients (68 men; 62 ± 10 years) underwent CTI either using a equipped with 8 mm (ME catheter) in 25 (Group A), dumbbell-shaped (DS) (DS 30 B), or cryothermal (Cryo C). In cases failed block, changed to other catheter, but remained original group following...
Right phrenic nerve injury (PNI) is a major concern during superior vena cava (SVC) isolation due to the anatomical close proximity. The functional and histological severity of PNI parallels degree reduction in compound motor action potential (CMAP) amplitude. This study aimed evaluate feasibility monitoring CMAPs SVC anticipate atrial fibrillation (AF) ablation.Thirty-nine paroxysmal AF patients were prospectively enrolled. Radiofrequency energy was delivered point-by-point for 30 seconds...
Dormant Conduction After Cryothermal PVI Background Adenosine triphosphate (ATP) testing reveals dormant pulmonary vein (PV) conduction after electrical PV isolation (PVI). This study aimed to evaluate the incidence of latent cryothermal PVI. Methods Fifty‐four consecutive paroxysmal atrial fibrillation patients undergoing were prospectively enrolled. was performed with one 28‐mm second‐generation balloon using a 3‐minute freeze technique, and touch‐up lesions created by focal applications....
Background:Deep sedation or general anesthesia is generally used during atrial fibrillation (AF) ablation. The aim of this study was to report the safety and feasibility minimal AF ablation.Methods Results:One thousand fifty-two ablation procedures in 819 patients (62±11 years, 621 men, 506 paroxysmal) were included. Boluses intravenous hydroxyzine pamoate pentazocine administered, with a maximal dose 100 mg 60 response pain. If pain intolerable requested deeper sedation, moderate using...