Willem Dieperink
A5090636377- Intensive Care Unit Cognitive Disorders
- Respiratory Support and Mechanisms
- Sepsis Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Cardiac Arrest and Resuscitation
- Cardiac, Anesthesia and Surgical Outcomes
- Frailty in Older Adults
- Airway Management and Intubation Techniques
- Hemodynamic Monitoring and Therapy
- Thermal Regulation in Medicine
- Family and Patient Care in Intensive Care Units
- Pneumonia and Respiratory Infections
- COVID-19 and healthcare impacts
- Cardiac Health and Mental Health
- Healthcare Technology and Patient Monitoring
- Nosocomial Infections in ICU
- Neonatal Respiratory Health Research
- Health Systems, Economic Evaluations, Quality of Life
- Infrared Thermography in Medicine
- Tracheal and airway disorders
- Intravenous Infusion Technology and Safety
- Palliative Care and End-of-Life Issues
- Antibiotic Use and Resistance
- Antibiotics Pharmacokinetics and Efficacy
University of Groningen
2015-2024
Hanze University of Applied Sciences
2020-2024
University Medical Center Groningen
2015-2024
De Wever-Ziekenhuis
2024
Maastricht University
2024
RELX Group (United States)
2024
Slagelse Hospital
2021
Aalborg University Hospital
2021
Aarhus University Hospital
2021
Hvidovre Hospital
2021
Prophylaxis for gastrointestinal stress ulceration is frequently given to patients in the intensive care unit (ICU), but its risks and benefits are unclear.In this European, multicenter, parallel-group, blinded trial, we randomly assigned adults who had been admitted ICU an acute condition (i.e., unplanned admission) were at risk bleeding receive 40 mg of intravenous pantoprazole (a proton-pump inhibitor) or placebo daily during stay. The primary outcome was death by 90 days after...
Patients with acute hypoxemic respiratory failure in the intensive care unit (ICU) are treated supplemental oxygen, but benefits and harms of different oxygenation targets unclear. We hypothesized that using a lower target for partial pressure arterial oxygen (Pao2) would result mortality than higher target.
Abstract Background The COVID-19 pandemic has led highly developed healthcare systems to the brink of collapse due large numbers patients being admitted into hospitals. One potential prognostic indicators in with is frailty. degree frailty could be used assist both triage intensive care, and decisions regarding treatment limitations. Our study sought determine interaction age elderly ICU patients. Methods A prospective multicentre ≥ 70 years care 138 ICUs from 28 countries was conducted....
Abstract Introduction The relationship between potassium regulation and outcome is not known. Our first aim in the present study was to determine level variability (ICU) stay outcome. second evaluate impact of a computer-assisted protocol. Methods We performed retrospective before-after including all patients >15 years age admitted for more than 24 hours ICU our university teaching hospital 2002 2011. Potassium control fully integrated with computerized glucose (glucose program intensive...
Background: The COVID-19 pandemic has resulted in a major influx of intensive care unit (ICU) admissions. Currently, there is limited knowledge on the long-term outcomes ICU-survivors and impact family members. This study aimed to gain an insight into physical, social psychological functioning their members at three- six-months following ICU discharge. Methods: A single-center, prospective cohort was conducted among Participants received questionnaires three six months after Physical...
In general, sleeping and activity patterns vary between individuals. This attribute, known as chronotype, may affect night shift performance. the intensive care unit (ICR), performance impact patient safety. We have investigated effect of chronotype social demographics on sleepiness, fatigue, nurses. was a prospective observational cohort study which assessed 96 ICU nurses during day shifts in mixed medical–surgical Netherlands. determined behaviour for each nurse prior to starting work...
The intensity of ventilation, reflected by driving pressure (ΔP) and mechanical power (MP), has an association with outcome in invasively ventilated patients or without acute respiratory distress syndrome (ARDS). It is uncertain if a similar exists coronavirus disease 2019 (COVID-19) failure.We aimed to investigate the impact ventilation on patient outcome. PRoVENT-COVID study national multicenter observational COVID-19 receiving invasive ventilation. Ventilator parameters were collected...
Intra-abdominal hypertension (IAH) is frequently present in critically ill patients and an independent predictor for mortality. Better recognition of clinically important thresholds necessary. Increased intra-abdominal pressure (IAP) associated with renal dysfunction, failure one the most consistently described organ dysfunctions IAH. Obesity also kidney injury. The underlying mechanisms are not yet fully understood. IAP may be a link this association. aim study was firstly to find range...
Abstract Background Intra-abdominal hypertension is frequently present in critically ill patients and an independent predictor for mortality. Risk factors intra-abdominal abdominal compartment syndrome have been widely investigated. However, data are lacking on prevalence outcome high-risk patients. Our objectives this study were to investigate of a prospective, observational, single-center cohort study. Results Between March 2014 2016, we included 503 patients, 307 males (61%) 196 females...
Abstract Metformin ( N , -dimethylbiguanide), an inhibitor of gluconeogenesis and insulin sensitizer, is widely used for the treatment type 2 diabetes. In some patients with renal insufficiency, metformin can accumulate cause lactic acidosis, known as metformin-associated acidosis (MALA, defined lactate ≥ 5 mM, pH < 7.35, concentration > 38.7 µM). Here, we report on post-translational modification (PTM) proline (Pro) to 4-hydroxyproline (OH-Pro) in metformin-treated Becker muscular...
Abstract Background Facial appearance, whether consciously or subconsciously assessed, may affect clinical assessment and treatment strategies in the Intensive Care Unit (ICU). Nevertheless, association between objective measurement of facial appearance multi-organ failure is currently unknown. The this study was to examine at admission associated with longitudinal evaluation failure. Methods This a sub-study Simple Studies-II, prospective observational cohort study. All adult patients...
The SpO2/FiO2 is a useful oxygenation parameter with prognostic capacity in patients ARDS. We investigated the of for mortality ARDS due to COVID-19.This was post-hoc analysis national multicenter cohort study invasively ventilated COVID-19. primary endpoint 28-day mortality.In 869 patients, 30.1%. on day 1 had no value. 2 and 3 death, best cut-offs being 179 199, respectively. Both (OR, 0.66 [95%-CI 0.46-0.96]) 0.70 0.51-0.96]) were associated model corrected age, pH, lactate levels kidney...
Family members of patients treated with Extracorporeal Membrane Oxygenation (ECMO) during an Intensive Care Unit (ICU) stay are at risk developing symptoms anxiety, depression and Post-Traumatic Stress Disorder (PTSD). Coping strategies used by family may play important role in the severity some these symptoms.The primary aim this study was to describe coping ECMO-treated ICU admission recovery period. The secondary explore course depression, PTSD, Health Related Quality Of Life (HRQOL) over...
Abstract Background Increasing evidence indicates the potential benefits of restricted fluid management in critically ill patients. Evidence lacks on optimal strategy for invasively ventilated COVID-19 We hypothesized that cumulative balance would affect successful liberation invasive ventilation patients with acute respiratory distress syndrome (ARDS). Methods analyzed data from multicenter observational ‘PRactice VENTilation patients’ study. Patients confirmed and ARDS who required during...
In this study, our aim was to explore how coronary artery bypass grafting affects quality of life, and varies with age, particularly patients at risk deterioration.In a retrospective, multicentre cohort isolated electively operated between January 2011 2015 pre- postoperative quality-of-life data were included. Patients classified into 3 age groups: <65, 65-79 ≥80 years. Quality life measured up 1-year follow-up using the Short Form-12 or Form-36 health survey. A multivariable, linear...
To describe the long-term functioning of patients who survived a COVID-19-related admission to intensive care unit and their family members, in physical, social, mental spiritual domain.A single-centre, prospective cohort study with mixed-methods design.The University Medical Center Groningen Netherlands.To 12 months after discharge several measurements were used, including standardised list physical problems, Clinical Frailty Scale, Outcomes Study Short-Form General Health Survey, McMaster...
Early initiation of continuous positive airway pressure (CPAP) applied by face mask benefits patients with acute cardiogenic pulmonary oedema (ACPE). The simple disposable Boussignac CPAP (BCPAP) has been used in ambulances physicians. In the Netherlands, are manned nurses and not It was hypothesised that ambulance able to identify ACPE can successfully apply BCPAP. A prospective case series presumed treated BCPAP is described.After training nurses, all 33 region were equipped diagnosed on...
Abstract Introduction Intensive care unit (ICU) patients are known to experience severely disturbed sleep, with possible detrimental effects on short- and long- term outcomes. Investigation into the exact causes of sleep has been hampered by cumbersome time consuming methods measuring staging sleep. We introduce a novel method for ICU depth analysis, index (IDOS index), using single channel electroencephalography (EEG) apply it outpatient recordings. A proof concept is shown in non-sedated...