A5015531406- Polysaccharides and Plant Cell Walls
- Polysaccharides Composition and Applications
- Chemical synthesis and alkaloids
- Metabolism, Diabetes, and Cancer
- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Wound Healing and Treatments
- Cholinesterase and Neurodegenerative Diseases
- Computational Drug Discovery Methods
- Pharmacological Effects of Natural Compounds
- Alkaloids: synthesis and pharmacology
- Animal Nutrition and Physiology
- Biochemical effects in animals
- Cancer-related molecular mechanisms research
- Microbial Metabolites in Food Biotechnology
- Microencapsulation and Drying Processes
- Fungal Biology and Applications
- Microbial Natural Products and Biosynthesis
- Natural product bioactivities and synthesis
- Acupuncture Treatment Research Studies
- Medicinal Plant Pharmacodynamics Research
- Plant Physiology and Cultivation Studies
- Medicinal Plants and Neuroprotection
- Chromatography in Natural Products
- Traditional and Medicinal Uses of Annonaceae
Lanzhou University of Technology
2011-2025
Affiliated Hospital of Nantong University
2024
Nantong University
2024
Nanjing Agricultural University
2021
Lanzhou City University
2020
Wuhan University
2002
The present work describes modifications to an existing TLC bioautographic method for detecting acetylcholinesterase inhibitors from plant extracts. basic principle of the is that enzyme converts 1-naphthyl acetate into naphthol which reacts with Fast Blue B salt make a purple-colored background on plates. Inhibitors acetylcholinesterases produced white spots background. Our involve changes in concentration enzyme, reagents, and time reaction. With these changes, consumption was reduced by...
Predicting the impact of mutations on protein-ligand binding affinity is crucial in drug discovery, particularly addressing resistance and repurposing existing drugs. Current structure-based methods, including deep learning physics-based computational techniques, are constrained by their dependence known complex structures. The lack structural data for mutated proteins, coupled with potential to alter protein conformational states, poses challenges reliable predictions. To address challenge,...
This study was conducted to investigate the effect of anhydrous betaine and hydrochloride on growth performance, meat quality, relaxometry, postmortem glycolysis, antioxidant capacity partridge shank broiler chickens. A total 400 one-day-old male broilers were randomly divided into 5 treatments fed basal diets supplemented with 0 (control), 500 (L-AB) or 1,000 (H-AB) mg/kg betaine, 642.23 (L-HB) 1,284.46 (H-HB) respectively. Compared control group, supplementation significantly increased (P...
Geissoschizine methyl ether (1), a newly discovered strong acetylcholinesterase (AChE) inhibitor, along with six weakly active alkaloids, vallesiachotamine (2), hisuteine (3), hirsutine (4), isorhynchophylline (5), cisocorynoxeine (6) and corynoxeine (7) have been isolated from Uncaria rhynchophylla. (1) inhibited 50% of AChE activity at concentrations 3.7 ± 0.3 µg mL(-1) while the IC(50) value physostigmine as standard was 0.013 0.002 mL(-1). The mode inhibition by 1 reversible...
1. This study investigated the effects of dietary betaine supplementation on growth performance, meat quality, muscle fatty acid composition and antioxidant ability in slow-growing broiler chickens.2. In total, 400, one-day-old female Xueshan chicks were randomly divided into five groups with eight replicates ten chickens each for 102 d. Broilers fed a basal diet supplemented 0, 125, 250, 500 or 1,000 mg/kg betaine.3. had better feed conversion efficiency weight gain (P < 0.05) increased...
The extraction kinetics and thermodynamic parameters of Glycyrrhiza polysaccharide (GP) were studied, its rheological properties antiviral activity evaluated.
The study explored the nature and structure of ultrasonically extracted Codonopsis pilosulae crude polysaccharides (CPCPs) effects CPCPs on hypoglycemic gut flora in a high glucose high-fat feeding STZ-induced T2DM mice model. results showed that consisted mainly polysaccharides, uronic acids, proteins SO42−. β-type pyranose exhibited porous, irregular fibrillation aggregation, inhibited activity α-amylase α-glucosidase. 1 g/kg reduced diabetic symptoms, including modulation body weight...
Biologically active coating materials could promote the growth of granulation tissue as auxiliary materials, while natural polysaccharides vascular regeneration and wound healing. Therefore, in this study, ultrasound-assisted extract Nostoc commune Vaucher (UAP) yield after process optimization was 12.89 ± 0.24%, which used to prepare microcapsules by emulsification cross-linking. The effect alginate/chitosan-UAP composite on healing an experimental rat model for 14 d its physical properties...
In this study, the extraction conditions ofNostoc communeVauch polysaccharide (NCVP) were optimized by single factor and orthogonal experiments. Then, NCVP microcapsules (NCVPM) prepared. After analyzing microcapsule structural thermal characteristics, skin wound healing ability was studied establishing back trauma rat models. Results showed that yield 10.37% under following optimum conditions: 210 min time, solid-liquid ratio of 1:50 temperature 90 °C. The overall performance best when...
Abstract The crude polysaccharide (CPNP) of Codonopsis pilosula was obtained by hot-water extraction technology. kinetic model established according to Fick’s first law diffusion and related parameters studied. CPNP microcapsules were prepared blending with sodium alginate, Ca 2+ ions CPNP. quality control (drug loading rate, embedding rate release etc) analyzed pharmacopeas standards. structure feature also determined various methods. wound healing ability different concentration evaluated...
The extraction condition of crude polysaccharides from Codonopsis pilosula by hot water reflux method was studied and the results analyzed kinetic model. Then, rate maximum temperature were determined. furthermore, thermal pH stability rheological properties polysaccharide also studied. (CCPP) under different conditions extracted method, content determined phenol-sulfuric acid DNS model process established. viscosity solute concentration, salt rotation speed, pH, temperature. determined;...
In this study, after optimizing the extraction process of CPP (Codonopsis pilosula polysaccharides), CPPM (CPP microcapsules) were prepared. Subsequently, structural characteristics and physicochemical properties studied. The results showed that is a hollow sac-like structure with rough folds protuberances comes in spherical or ellipsoidal shapes uniform particle size. has certain swelling degree, low hardness, good adhesion, stability. Then, effect on wounds repair was investigated by rat...
Response surface methodology (RSM) was applied to predict optimum conditions for microwave-assisted extraction (MAE) of crude water-soluble polysaccharides from Piteguo fruit (PTG). A central composite design used optimize microwave power (X1: 400 – 600 W), time (X2: 5 10 min) and ratio water material (W/M ratio, X3: 30:1 50:1 mL/g) obtain a high yield. The statistical analyses indicated that all the three factors had significant effect on yield (p < 0.001). results showed up 7.86% under as...
Abstract Microbial communities that inhabit aging tobacco leaves play a key role in improving products quality. A better understanding of microbial on the could provide an important repository for industrial applications. Here, we examined structural and compositional changes throughout process by 16 S ITS rRNA amplicon sequencing techniques identified potential metabolic pathways bacteria fungi using Functional Annotation Prokaryotic Taxa (FAPROTAX) Fungi Guild (FUNGuild), respectively. The...