A5056683708- Stress Responses and Cortisol
- Neuroendocrine regulation and behavior
- Inhalation and Respiratory Drug Delivery
- Drug Solubulity and Delivery Systems
- Regulation of Appetite and Obesity
- Advanced Drug Delivery Systems
- Transplantation: Methods and Outcomes
- Hormonal Regulation and Hypertension
- Circadian rhythm and melatonin
- Adipose Tissue and Metabolism
- Protein purification and stability
- Microencapsulation and Drying Processes
- Crystallization and Solubility Studies
- Organ Transplantation Techniques and Outcomes
- Hypothalamic control of reproductive hormones
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Nanoparticle-Based Drug Delivery
- Adrenal Hormones and Disorders
- Biochemical effects in animals
- Electrolyte and hormonal disorders
- Pulmonary Hypertension Research and Treatments
- Asthma and respiratory diseases
- Renal Transplantation Outcomes and Treatments
- Pharmaceutical studies and practices
- Advancements in Transdermal Drug Delivery
Catalent (United States)
2022
The University of Texas at Austin
2010-2020
University of Southern California
2001-2018
Austin College
2008-2017
The University of Texas Health Science Center at San Antonio
2008-2015
Audie L. Murphy Memorial VA Hospital
2015
Russells Hall Hospital
2015
Southern California University for Professional Studies
2007-2011
Pediatrics and Genetics
2007-2009
Massachusetts General Hospital
2000
Corticotropin-releasing hormone (CRH)-containing neurons in the paraventricular nucleus of hypothalamus (PVN) initiate and control neuroendocrine responses to psychogenic physical stress. Investigations into physiology CRH neurons, however, have been hampered by lack tools for adequately targeting or visualizing this cell population. Here we characterize PVN mice that express tdTomato fluorophore, generated crosses recently developed Crh-IRES-Cre driver Ai14 Cre-reporter mouse strains....
Hindbrain norepinephrine (NE) and epinephrine (E) neurons play a pivotal role in the central distribution of sensory signals derived from internal environment. Their projections influence various secretory patterns hypothalamo-pituitary-adrenal axis are essential for feeding adrenal medullary responses to glucoprivation. NE E terminals paraventricular nucleus hypothalamus (PVH) associated hindbrain cell bodies can be virtually eliminated by PVH microinjection retrogradely transported...
1. We have determined in adrenalectomized male rats the effects of clamping plasma corticosterone and aldosterone at various concentrations on corticotropin‐releasing hormone (CRH), neurotensin/neuromedin N (NT/N) proenkephalin (pENK) mRNAs hypothalamus amygdala using semi‐quantitative situ hybridization. 2. Corticosterone differentially regulated levels CRH NT/N but not pENK mRNA. These were cell specific. mRNA was reduced hypothalamic paraventricular nucleus (PVH), increased central bed...
Journal Article Diurnal Variations in the Content of Preprocorticotropin-Releasing Hormone Messenger Ribonucleic Acids Hypothalamic Paraventricular Nucleus Rats Both Sexes as Measured by Situ Hybridization Get access A. G. WATTS, WATTS 1Neural Systems Laboratory, The Salk Institute for Biological Studies, Howard Hughes Medical InstituteLa Jolla, California 92037 Search other works this author on: Oxford Academic Google Scholar L. W. SWANSON Endocrinology, Volume 125, Issue 3, 1 September...
CSP7, a caveolin-1–derived peptide, targets injured alveolar epithelial cells and activated lung fibroblasts to mitigate pulmonary fibrosis.
Described here is the development of gadolinium(III) texaphyrin-platinum(IV) conjugates capable overcoming platinum resistance by 1) localizing to solid tumors, 2) promoting enhanced cancer cell uptake, and 3) reactivating p53 in platinum-resistant models. Side side comparative studies these Pt(IV) clinically approved platinum(II) agents previously reported platinum(II)-texaphyrin demonstrate that present are more stable against hydrolysis nucleophilic attack. Moreover, they display high...
To drive the daily ACTH secretory rhythm from anterior pituitary corticotropes signals circadian clock schedule CRH and, to lesser extent, arginine vasopressin (AVP) release neuroendocrine terminals. In turn, releasable pools of and AVP in terminals are sustained by synthetic mechanisms medial parvicellular paraventricular nucleus, a critical component which involves transcribing primary (heteronuclear (hn)) RNA transcripts their cognate genes. determine fundamental patterns secretagogue...
The development of many endocrine, metabolic, and behavioral abnormalities characteristic genetically obese Zucker rats is dependent upon the presence glucocorticoids, secretion which regulated by a neuroendocrine cascade initiated hypothalamic release CRF. Recent reports have inferred alterations in central CRF tone as putative factor contributing to dysregulation pituitary-adrenal axis metabolic processes this phenotype. In current study system lean (FA/?) (fa/fa) phenotypes was...
Invasive pulmonary aspergillosis is a deadly fungal infection with high mortality rate, particularly in patients having undergone transplant surgery. Voriconazole, triazole antifungal pharmaceutical product, considered as first-line therapy for invasive aspergillosis, and exhibits efficacy even who have failed other drug therapies. The objective of this study to develop potency nanoaggregates crystalline voriconazole composition dry powder inhalation using the particle engineering process,...