A5029608114- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Nanoplatforms for cancer theranostics
- Lipid Membrane Structure and Behavior
- Dendrimers and Hyperbranched Polymers
- Porphyrin and Phthalocyanine Chemistry
- Cancer therapeutics and mechanisms
- Advanced biosensing and bioanalysis techniques
- Retinoids in leukemia and cellular processes
- Malaria Research and Control
- Nanomaterials for catalytic reactions
- Curcumin's Biomedical Applications
- Nanocluster Synthesis and Applications
- Immune cells in cancer
- Advanced Nanomaterials in Catalysis
- Phagocytosis and Immune Regulation
- Extracellular vesicles in disease
- Biopolymer Synthesis and Applications
- HIV Research and Treatment
- Autoimmune and Inflammatory Disorders Research
- Medicinal Plants and Neuroprotection
- Gold and Silver Nanoparticles Synthesis and Applications
- 3D Printing in Biomedical Research
- Click Chemistry and Applications
- Plant-derived Lignans Synthesis and Bioactivity
Yantai University
2020-2023
Southeast University
2017-2021
Retinal ischemia-reperfusion (RIR) injury is involved in the pathogenesis of various vision-threatening diseases. The overproduction reactive oxygen species (ROS) thought to be main cause RIR injury. A variety natural products, including quercetin (Que), exhibit potent antioxidant activity. However, lack an efficient delivery system for hydrophobic Que and presence intraocular barriers limit effective retinal clinical settings. In this study, we encapsulated into ROS-responsive...
Rheumatoid arthritis (RA) is an autoimmune inflammatory disorder that has seriously affected human health worldwide and its current management requires more successful therapeutic approaches. The combination of nanomedicines pathophysiology into one system may provide alternative strategy for precise RA treatment. In this work, a practical ROS-mediated liposome, abbreviated as Dex@FA-ROS-Lips comprised synthetic dimeric thioether lipids (di-S-PC) surface functionalized with folic acid (FA),...
Micelles self-assembled from small amphiphilic molecules are unstable in biological fluids, and thus poor drug carriers. In contrast, polymer micelles can encapsulate hydrophobic drugs their core to greatly enhance aqueous solubility extend retention time blood circulation owing hydrophilic shell. However, the major disadvantages of conventional heterogeneity structure premature leakage. Thus, herein, address these shortcomings, disulfide crosslinked composed a molecule,...
Nanomedicines in polymeric therapeutics present a potential treatment for cancers. However, their clinical effectiveness still has room to be improved. Herein, reduction-responsive reversibly core-cross-linked micelles based on the poly(ethylene glycol)-dihydrolipoic acid (MeO-PEG2k-DHLA) conjugate were developed triggered intracellular release of camptothecin (CPT). Coupling two molecules dihydrolipoic (DHLA) methyl-terminated PEG (Mw 2000) through labile ester bond was performed by...
The increasing application of gold nanoparticles (AuNPs) in biomedicine requires extensive investigation surface modification and stabilization to maximize their advantages for the diversity more challenging biological utilization. Herein, a thiol-mediated multifunctional phospholipid ligand was designed while disclosing zwitterionic nature AuNPs. synthesized by attachment two bidentate lipoic acid (LA) anchor groups incorporation phosphatidylcholine (PC) group, allowing excellent...
Aim: A novel amphiphilic prodrug dual podophyllotoxin (PPT) succinate glycerophosphorylcholine (Di-PPT-GPC) assembled liposomes was developed to improve efficiency of PPT. Materials & methods: Di-PPT-GPC were prepared by thin film technique and characterized dynamic light scattering cryo-electron microscopy. Results: In vitro release studies showed that could significantly PPT in weakly acidic environment but had good stability under biological conditions. Methyl tetrazolium assay data...
A liposomal platform self-assembled from a novel and universal synthetic dimeric-drug phospholipid.