A5103115154- Cancer Cells and Metastasis
- Cell Adhesion Molecules Research
- Endoplasmic Reticulum Stress and Disease
- Immune cells in cancer
- Hippo pathway signaling and YAP/TAZ
- Renal and related cancers
- Cancer, Hypoxia, and Metabolism
- Congenital Heart Disease Studies
- Bioinformatics and Genomic Networks
- Advanced Breast Cancer Therapies
- Cancer-related Molecular Pathways
- Epigenetics and DNA Methylation
- Genomics and Chromatin Dynamics
- Breast Cancer Treatment Studies
- Cancer Genomics and Diagnostics
- Renal cell carcinoma treatment
- Lung Cancer Research Studies
- Gene expression and cancer classification
- Cancer Treatment and Pharmacology
- Lung Cancer Treatments and Mutations
- Prostate Cancer Treatment and Research
- Cancer Immunotherapy and Biomarkers
China Medical University
2020-2025
Abstract HA121-28, a promising multikinase inhibitor, mainly targets rearranged during transfection (RET) fusions and selectively vascular endothelial growth factor receptor-2, receptor, fibroblast receptor 1-3. The safety, pharmacokinetics, efficacy of HA121-28 were assessed in advanced solid tumors (phase 1, ClinicalTrials.gov NCT03994484) RET fusion-positive non-small-cell lung cancer (RET-TKI naive NSCLC, phase 2, NCT05117658). was administered orally doses range from 25 to 800 mg under...
Background: Integrin family are known as key gears in focal adhesion for triple-negative breast cancer (TNBC) metastasis. However, the integrin independent factor TLN1 remains vague TNBC. Methods: Bioinformatics analysis was performed based on TCGA database and Shengjing Hospital cohort. Western blot RT-PCR were used to detect expression of pathway cells. A small-molecule C67399 screened blocking β1 through a novel computational screening approach by targeting protein-protein binding...
The Glycine N-acyltransferase (GLYAT) gene encodes a protein that catalyzes the transfer of acyl groups from CoA to glycine, resulting in glycine and coenzyme A. Aberrant GLYAT expression is associated with several malignant tumors, but its clinical importance human breast cancer (BC), has yet be fully addressed. This study aims evaluate function BC patients.GLYAT was determined by immune blot immunohistochemistry three cell lines primary tissues. MDA-MB 231 line used for knockdown...
Purpose: The role of heat shock protein 70 (HSC70) in the progression clear cell renal carcinoma (ccRCC) is unclear. This study explored effect HSC70 on survival ccRCC patients. Methods: Immunohistochemical analysis was performed to determine expression samples obtained from 121 patients with at least 5 years follow-up. We also analyzed association between and clinicopathological characteristics. Furthermore, overall (OS) using Kaplan-Meier curves. Finally, we used Oncomine CCLE databases...
The occurrence and development of breast cancer has a strong correlation with person's genetics. Therefore, it is important to analyze the genetic factors for future potential targeted therapies from level. In this study, we complete an analysis relevant protein-protein interaction network relating cancer. This includes three steps, which are cancer-relevant genes selection using mutual information method, reconstruction based on STRING database, vital calculating by nodes centrality...
e12604 Background: Despite cyclin dependent kinase 4/6 (CDK4/6) inhibitors having revolutionized treatment for advanced hormone receptor (HR)-positive, HER2-negative (HR+/HER2-) breast cancer, it still has limited efficacy in the neoadjuvant setting. Preclinical studies have indicated radiotherapy followed by CDK4/6 can enhance antineoplastic effects. Stereotactic body (SBRT) is more effective than conventional fractionation. This MUKDEN 03 pilot study aimed to explore and safety of a...