A5115593145- Advanced Battery Materials and Technologies
- Advancements in Battery Materials
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Advanced Battery Technologies Research
- Metabolism, Diabetes, and Cancer
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Conducting polymers and applications
- Cancer-related molecular mechanisms research
- Breast Cancer Treatment Studies
- Chronic Kidney Disease and Diabetes
- Renal and related cancers
- Protein Kinase Regulation and GTPase Signaling
- Advanced battery technologies research
- Thermal Expansion and Ionic Conductivity
- Cancer Cells and Metastasis
- Genetic and Kidney Cyst Diseases
- Nuclear Structure and Function
- ATP Synthase and ATPases Research
- Ferroptosis and cancer prognosis
- Crustacean biology and ecology
- Electrocatalysts for Energy Conversion
- Frailty in Older Adults
- Marine and fisheries research
Dalian University of Technology
2025
Merck & Co., Inc., Rahway, NJ, USA (United States)
2024
China Medical University
2019-2024
Ocean University of China
2024
Zhejiang University
2024
Shanghai Jiao Tong University
2021-2024
Xuzhou Medical College
2023-2024
Qingdao University
2024
Henan Agricultural University
2023
Sheng Jing Hospital
2022-2023
Abstract Lithium metal batteries (LMBs) suffer severe capacity deterioration due to sluggish ionic transport kinetics at extremely low temperatures, which limits their practical operation. Selecting solvents with desolvation energy, and promoting interfacial Li + in solid electrolyte interphase (SEI) are regarded as effective methods improve electrochemical performances. Herein, 1,3‐dioxolane (DOL) weak solvating power is adopted for designing a DOL‐based localized high concentration (DLHCE)...
We investigated whether microRNA-150 (miR-150)-based RNA interference (RNAi) ameliorates tubular injury and tubulointerstitial fibrosis. Mice injected with folic acid developed fibrosis at day 30. miR-150 levels were increased 7 peaked At 30, protein of α-smooth muscle actin, fibronectin (FN), collagen 1 (COL-1) increased, while suppressor cytokine signal (SOCS1) was decreased. Kidneys manifested macrophage numbers expression potential mediators: interferon-γ, interleukin-6, tumor necrosis...
Breast cancer stem-like cells (BCSCs) have been suggested as the underlying cause of tumor recurrence, metastasis and drug resistance in triple-negative breast (TNBC). Here, we report discovery biological evaluation a highly potent small-molecule antagonist exportin-1, LFS-1107. We ascertained that exportin-1 (also named CRM1) is main cellular target LFS-1107 by nuclear export functional assay, bio-layer interferometry binding assay C528S mutant cell line. found significantly inhibited TNBC...
Background/Objectives: In a tonal language like Chinese, phonologically contrasting tones signify word meanings at the syllable level. Although development of lexical tone perception ability has been examined in many behavioral studies, its developmental trajectory from childhood to adulthood neural level remains unclear. This cross-sectional study aimed examine issue by measuring mismatch negativity (MMN) response Chinese contrast three groups. Methods: The MMN flat-falling (Tone1 versus...
Abstract Background The prevalence of lupus nephritis (LN) remains high despite various emerging monoclonal antibodies against with targeting systemic erythematosus (SLE). Renal fibrosis is the main feature late stage LN, and novel therapeutic agents are still needed. We previously reported that microRNA (miR)-150 increases in renal biopsies American LN patients miR-150 agonist promotes cultured kidney cells. Presently, we aim to verify whether locked nucleic acid (LNA)-anti-miR-150 can...
Inflammation is an important factor in the progression from acute kidney injury (AKI) to chronic disease (CKD). The role of interleukin (IL)-18 this has not been examined. We aimed clarify whether and how IL-18 limits progression. In a folic acid induced renal mouse model, we studied time course expression. wild-type mice following injection, expression increased. parallel, characterized other processes, including at day 2, tubular necroptosis assessed by receptor-interacting...
Abstract Lithium‐ion batteries commonly exhibit a gradual loss of Li‐storage capacity during operation and storage. However, they can also abruptly lose much their in rollover fashion (i.e., “sudden death”) under aggressive but practically relevant conditions, such as high‐voltage or cycling at elevated temperatures. Here the origin failure is investigated high‐energy LiNi 0.80 Co 0.15 Al 0.05 O 2 ‐graphite (NCA‐Gr) cycled 55 °C. A combined chemical, structural, electrochemical studies...
Renal tubulointerstitial fibrosis is a common pathological feature of progressive chronic kidney disease (CKD), and current treatment has limited efficacy. The circular RNA circHIPK3 reported to participate in the pathogenesis various human diseases. However, role renal not been examined. In this study, we aimed determine whether how might fibrosis. Mice received peritoneal injection folic acid (250 mg/kg). Of note, 30 days later, was present on periodic acid–Schiff (PAS) Masson staining,...
A sodium ion based organic radical battery has been developed using a polynorbornene derivative polymer as the cathode active material. The electrochemical performances of are preliminarily investigated, showing cyclability battery. delivers discharge capacity at 1st cycle and retention 50th cycle.
Renal interstitial fibrosis (RIF) is a common pathological feature contributing to chronic injury and maladaptive repair following acute kidney injury. Currently, there no effective therapy for RIF. We have reported that locked nuclear acid (LNA)-anti-miR-150 antagonizes pro-fibrotic pathways in human renal tubular cells by regulating the suppressor of cytokine signal 1 (SOCS1)/Janus kinase (JAK)/signal transducer activator transcription (STAT) pathway. In present study, we aimed clarify...
Vasopressin V2 receptors (V2R) are a promising drug target for autosomal dominant polycystic kidney disease (ADPKD). As previous research demonstrated that the residence time of V2R antagonists is critical to their efficacy in both ex vivo and models ADPKD, we performed extensive structure–kinetic relationship (SKR) analyses on series benzodiazepine derivatives. We found subtle structural modifications derivatives dramatically changed binding kinetics but not affinity. Compound 18 exhibited...
A cancer-associated mutation in protein kinase Cι selectively disrupts epithelial polarity by inhibiting the binding of specific substrates.
Purpose: Lymph node metastasis is a multifactorial event. Several scholars have developed nomograph models to predict the sentinel lymph nodes (SLN) before operation. According clinical and pathological characteristics of breast cancer patients, we use new method establish more comprehensive model add some factors which never been analyzed in world explored prospect its application. Materials methods: The clinicopathological data 633 patients with who underwent SLN examination from January...
All-solid-state sodium batteries (ASSSBs) are attractive alternatives to lithium-ion for grid-scale energy storage due their high safety and ubiquitous distribution of Na sources. A critical component ASSSB is sodium-ion conducting solid-state electrolyte (SSE). Here, we report a high-performance SSE with the recently developed bulk interfacial superionic conductor (BISC) concept. The ionic conductivity areal conductance Na+ BISC at 25 °C reaches 6.5 × 10-4 S cm-1 260 mS cm-2, respectively....
Recent studies have focused on nuclear-encoded circular RNAs (circRNAs) in kidney diseases, but little is known about mitochondrial circRNAs. Differentially expressed circRNAs were analyzed by RNA deep sequencing from lupus nephritis (LN) biopsies and normal human kidneys. In LN renal biopsies, the most downregulated circRNA was circMTND5, which encoded genome. We quantitated circMTND5 qPCR localized fluorescence situ hybridization (FISH). Mitochondrial abnormalities identified electron...
Iron overload is common in cardiovascular disease, it also the factor that drives ferroptosis. Noncoding RNAs play an important role heart disease; however, their regulatory iron overload-mediated ferroptosis remains much unknown. In our study, model mice was constructed through a high-iron diet, and ammonium citrate treatment used to mimic vitro. We found induced cardiomyocytes, which dependent on high expression of transferrin receptor (TFRC). MiR-31-5p downregulated during overload;...
Abstract Succinonitrile (SCN) based plastic crystal electrolytes (SPCEs) have attracted much attention for lithium metal batteries due to their considerable ionic conductivity and thermal stability. Insufficient mechanical properties, weak reductive stability, the presence of free SCN molecules can result in adverse interfacial reactions. Polymer introduction has been explored address these challenges. However, polymer affects state, leading reduced conductivity, potentially limited...
Abstract Lipase member H (LIPH), a novel of the triglyceride lipase family. The clinical implications its expression in breast cancer are still unclear. Therefore, this study, we investigated associations between LIPH and tumorigenic behaviours 144 triple‐negative (TNBC) patients. ratio mammosphere‐forming ability CD44+/CD24− stem‐like cells were tested. role cell migration invasion was also evaluated. In addition, effect silencing on mitochondrial respiration determined using Seahorse...
Journal Article Cohort Profile: The Northeast China Biobank (NEC-Biobank) Get access Qing Chang, Chang Clinical Research Center, Shengjing Hospital of Medical University, Shenyang, Search for other works by this author on: Oxford Academic PubMed Google Scholar Qijun Wu, Wu Department Epidemiology, Yang Xia, Xia Hehua Zhang, Zhang Shanyan Gao, Gao Yixiao Urology Surgery, Yuan Yuan, Tumor Etiology and Screening Cancer Institute General Key Laboratory Prevention in Liaoning Education...