A5100635282- Cancer Cells and Metastasis
- Liver Disease Diagnosis and Treatment
- Sperm and Testicular Function
- Advanced Breast Cancer Therapies
- Global Health Care Issues
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- COVID-19 and Mental Health
- HER2/EGFR in Cancer Research
- Nutritional Studies and Diet
- Healthcare professionals’ stress and burnout
- Radiomics and Machine Learning in Medical Imaging
- Cancer Immunotherapy and Biomarkers
- COVID-19 diagnosis using AI
- Ovarian function and disorders
- Autophagy in Disease and Therapy
- Digestive system and related health
- Immune cells in cancer
- Prostate Cancer Treatment and Research
- Cancer-related Molecular Pathways
- Diet and metabolism studies
- Hippo pathway signaling and YAP/TAZ
- vaccines and immunoinformatics approaches
- Sirtuins and Resveratrol in Medicine
- Cell Adhesion Molecules Research
China Medical University
2009-2025
Capital Medical University
2023-2025
Beijing Chao-Yang Hospital
2025
Beijing Institute of Technology
2024
Liaoning University
2024
Capital University
2023
Johns Hopkins University
2019-2023
Henan Agricultural University
2023
First Affiliated Hospital of Fujian Medical University
2023
Fujian Medical University
2023
An increasing number of public datasets have shown a marked impact on automated organ segmentation and tumor detection. However, due to the small size partially labeled problem each dataset, as well limited investigation diverse types tumors, resulting models are often segmenting specific organs/tumors ignore semantics anatomical structures, nor can they be extended novel domains. To address these issues, we propose CLIP-Driven Universal Model, which incorporates text embedding learned from...
Abstract Early detection is critical to achieving improved treatment outcomes for child patients with congenital heart diseases (CHDs). Therefore, developing effective CHD techniques using low-cost and non-invasive pediatric electrocardiogram are highly desirable. We propose a deep learning approach detection, CHDdECG, which automatically extracts features from wavelet transformation characteristics, integrates them key human-concept features. Developed on 65,869 cases, CHDdECG achieved...
The incidence density of metabolic dysfunction-associated fatty liver disease (MAFLD) and the effect a healthy lifestyle on risk MAFLD remain unknown. We evaluated prevalence investigated association between MAFLD.
Venous thromboembolism (VTE) is a major, frequent, and potentially fatal health issue worldwide. Community-acquired pneumonia (CAP) one of the leading causes hospitalization parapneumonic pleural effusion (PPE) relatively common complication pneumonia. Whether PPE risk factor for VTE in hospitalized patients with CAP has not been studied before. We retrospectively reviewed all diagnosed admitted to our center from 1 January 31 August 2019. The clinical laboratory data were collected medical...
ABSTRACT Fusarium crown rot (FCR) and sharp eyespot (SE) are serious soil‐borne diseases in wheat its relatives that have been reported to cause yield losses many areas. In this study, the expression of a cell wall invertase gene, TaCWI‐B1 , was identified be associated with FCR resistance through combination bulk segregant RNA sequencing genome resequencing recombinant inbred line population. Two bi‐parental populations were developed further verify association resistance. Overexpression...
Background: Integrin family are known as key gears in focal adhesion for triple-negative breast cancer (TNBC) metastasis. However, the integrin independent factor TLN1 remains vague TNBC. Methods: Bioinformatics analysis was performed based on TCGA database and Shengjing Hospital cohort. Western blot RT-PCR were used to detect expression of pathway cells. A small-molecule C67399 screened blocking β1 through a novel computational screening approach by targeting protein-protein binding...
Abstract Background Breast cancer metastasis to the bone can be exacerbated by osteoporosis, is associated with poor long-term survival, and has limited therapeutic options. Sclerostin (SOST) an endogenous inhibitor of formation, attractive target for treatment osteoporosis. However, it unclear whether SOST used as a metastases breast cancer, small molecule compounds that in cells inhibit metastasis. Methods expression 442 tissues was characterized immunohistochemistry statistically analyzed...
An increasing number of public datasets have shown a marked impact on automated organ segmentation and tumor detection. However, due to the small size partially labeled problem each dataset, as well limited investigation diverse types tumors, resulting models are often segmenting specific organs/tumors ignore semantics anatomical structures, nor can they be extended novel domains. To address these issues, we propose CLIP-Driven Universal Model, which incorporates text embedding learned from...
Tumor metastasis remains the main cause of breast cancer-related deaths, especially delayed cancer distant metastasis. The current study assessed frequency CD44 - /CD24 cells in 576 tissue specimens for associations with clinicopathological features and investigated underlying molecular mechanisms. results indicated that higher (≥19.5%) was associated postoperative Furthermore, triple negative (TNBC) spontaneously converted into + stem (CSCs) properties similar to CSCs from primary human...
Background Checkpoint targets play a key role in tumor-mediated immune escape and therefore are critical for cancer immunotherapy. Unfortunately, there is lack of bioinformatics resource that compile all the checkpoint translational research drug discovery immuno-oncology. Methods To this end, we developed therapeutic target database (CKTTD), first comprehensive (proteins, miRNAs LncRNAs) their modulators. A scoring system was adopted to filter more relevant with high confidence. In...
Recent evidences from clinical trials (NCT04486911) revealed that the combination of pyrotinib, letrozole, and dalpiciclib exerted optimistic therapeutic effect in treating HER2+HR+ breast cancer; however, underlying molecular mechanism remained elusive. Through drug sensitivity test, efficacy tamoxifen, to BT474 cells was tested. The mechanisms were investigated using immunofluorescence, Western blot analysis, immunohistochemical staining, cell cycle analysis. Potential risk factor may...
To explore the prevalence of major anxiety and its associated risk factors in residents China.This multicenter, cross-sectional study was conducted from December 2019 to February 2020; 1,343 8 hospitals Northeast China were included final analysis (effective response rate 86.48%). Demographic characteristics, dietary habits, life-related factors, work-related psychological characteristics collected participants via a self-reported questionnaire. This questionnaire measured sleep quality,...
Background: The role of meat and vegetable intake in the development asthenozoospermia has been controversial, cooking methods for vegetables association yet to be determined. present study aimed illuminate relationship between consumption risk asthenozoospermia. Methods: In this hospital-based case-control study, we enrolled 552 patients with 585 healthy controls. Dietary information was assessed using a validated self-administered food frequency questionnaire. Asthenozoospermia diagnosed...
Is dietary total antioxidant capacity (DTAC) associated with the odds of developing asthenozoospermia in Chinese men?There is no statistically significant association between DTAC indices and asthenozoospermia.Both diet oxidative stress may be related to sperm quality; however, few studies have investigated quality.This case-control study was conducted from June 2020 December 2020. Those diagnosed were assigned case group, whereas those normal parameters control group. Data a 553 cases 586...
ABSTRACT Background At present, there is no epidemiological evidence of the association between metabolic kidney diseases (MKD) and exposure to air pollution. Methods We investigated long-term pollution risk developing MKD using samples from Northeast China Biobank. Results Data 29 191 participants were analyzed. prevalence was 3.23%. Every standard deviation increment in PM2.5 increased [odds ratio (OR) = 1.37, 95% confidence interval (CI) 1.19–1.58), diabetic disease (DKD) (OR 2.03, CI...