A5076577662- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Hepatitis Viruses Studies and Epidemiology
- Liver Disease and Transplantation
- Cancer, Lipids, and Metabolism
- MicroRNA in disease regulation
- HIV/AIDS Research and Interventions
- Ferroptosis and cancer prognosis
- Viral gastroenteritis research and epidemiology
- Sarcoma Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- Phagocytosis and Immune Regulation
- Immune Cell Function and Interaction
- Liver physiology and pathology
- Inflammatory Biomarkers in Disease Prognosis
- Polyomavirus and related diseases
- Adipose Tissue and Metabolism
- Muscle Physiology and Disorders
- Immune responses and vaccinations
- Autophagy in Disease and Therapy
- Reproductive tract infections research
- Protein Degradation and Inhibitors
- Viral-associated cancers and disorders
- Vascular Tumors and Angiosarcomas
China Medical University
2013-2025
Children's Hospital of Philadelphia
2018-2024
Sheng Jing Hospital
2024
Zhongnan Hospital of Wuhan University
2022-2023
Wuhan University
2022-2023
Hubei Provincial Center for Disease Control and Prevention
2023
Zhejiang Provincial People's Hospital
2023
China Agricultural University
2023
Hebei Medical University
2011-2022
Weatherford College
2022
The main transmission route of the hepatitis B virus (HBV) is mother to child and contributes significantly chronic HBV infection. Even though immunoprophylaxis with immunoglobulin (HBIG) vaccine administrated neonates whose mothers are surface antigen (HBsAg) positive, about 10% suffer from infection in their early life.To survey among pregnant women infants analyze reason for failure.Serum HBsAg was tested all women. HBVDNA other serum markers including e (HBeAg), core antibody (anti-HBc)...
Summary Background Data on tenofovir alafenamide fumarate (TAF) for preventing mother‐to‐child transmission of hepatitis B virus (HBV) are lacking. Aims To investigate the efficacy and safety TAF therapy transmission. Methods Mothers with chronic HBV infection, positive e‐antigen DNA >200 000 IU/mL received were enrolled retrospectively from multiple centres data collection mother‐infant dyads up to postpartum week 24‐28. Primary measurements rate infants' malformation rate. Secondary...
Summary We evaluated the efficacy and safety of telbivudine (LdT, 600 mg/day) vs control patients (no treatment) in decreasing vertical transmission HBV , HB eAg‐positive mothers ( HBVDNA >6log 10 copies/ mL ). pregnant women either second or third trimester were recruited a prospective, case–control, open‐label study, at Second Affiliated Hospital Southeast University, China (February 2008‐December 2010). Efficacy (month 7: (+), sAg (+) infants) overall group treated was analysed using...
Fgf21 has been identified as playing a regulatory role in muscle growth and function. Although the mechanisms through which endurance training regulates skeletal have widely studied, contribution of remains poorly understood. Here, size function were measured, markers fiber type evaluated using immunohistochemistry, immunoblots, or qPCR endurance-exercise-trained wild-type KO mice. We also investigated Fgf21-induced conversion C2C12 cells, incubated with lentivirus and/or pathway inhibitors....
Nucleos(t)ide analogues (NAs) have been widely used for the treatment of chronic hepatitis B (CHB). Because viral DNA polymerase lacks proofreading function (3′ exonuclease activity), theoretically, incorporated NAs would irreversibly terminate synthesis. This study explored natures nascent virus (HBV) and infectivity progeny virions produced under NA treatment. HBV was determined by infection HepG2‐NTCP cells primary human hepatocytes (PHHs). Biochemical properties in were investigated...
The World Health Organization (WHO) has set the goal of eliminating hepatitis as a threat to public health by 2030. Blocking mother-to-child transmission (MTCT) B virus (HBV) is not only key viral hepatitis, but also hot issue in field prevention and treatment. To standardize clinical management preventing MTCT HBV achieve zero infection among infants, Chinese Foundation for Hepatitis Prevention Control organized experts compile algorithm based on latest research progress guidelines,...
Preventing hepatitis B virus (HBV) mother-to-child transmission (MTCT) is the key to controlling prevalence of chronic HBV infection. Adequate awareness in s antigen (HBsAg) positive pregnant women may be helpful reduce MTCT. The aim this study was explore seroprevalence among and investigate level HBsAg women. serum biomarkers were tested visiting Shengjing Hospital China Medical University. HBsAg-positive received a DNA test completed questionnaire. different loads interpreted as follows:...
Summary Telbivudine, an FDA pregnancy category B drug, has been found to reduce hepatitis virus (HBV) perinatal transmission with no safety concerns in infants aged up 1 year. This study evaluated the long‐term efficacy and of telbivudine 214 born 210 pregnant women chronic infection who were treated during (weeks 20‐32 gestation). The followed for 5 years after birth. endpoint was rate transmission, which established by HBsAg HBV DNA levels at 7 12 months. Safety endpoints included head...
Undifferentiated embryonal sarcoma of the liver (UESL) is a rare malignancy originating from primary mesenchymal tissue. The clinical manifestations, laboratory tests, and imaging examinations disease lack specificity preoperative misdiagnosis rate high. overall prognosis poor survival low.To investigate diagnosis, treatment, UESL.We performed retrospective, single-center cohort study in Shengjing Hospital China Medical University, which central hospital northeast China. From 2005 to 2017,...
Abstract Objectives The purpose of this study was to explore whether pretreatment potential prognostic factors are related chemotherapeutic outcomes and the prognosis inpatients with metastatic colorectal cancer (mCRC) undergoing chemotherapy. Materials methods Data from 71 patients mCRC were analyzed retrospectively. relationship between before first‐line chemotherapy clinicopathological characteristics response calculated using Fisher's exact test chi‐square test. univariate multivariate...
Abstract Liver fibrosis is a severe health problem worldwide, and it characterized by the activation of hepatic stellate cells (HSCs) excessive deposition collagen. Prolonged arsenic exposure can induce HSCs liver fibrosis. In present study, results showed that chronic NaAsO 2 ingestion could result in oxidative stress Sprague–Dawley rats, along with representative collagen activation. addition, inositol‐requiring enzyme 1α (IRE1α)–endoplasmic reticulum (ER)‐stress pathway was activated,...
The hepatitis B virus (HBV) has been classified into eight genotypes (A-H) based on intergenotypic divergence of at least 8% in the complete nucleotide sequence or more than 4% S gene. To facilitate investigation relationship between efficacy drug treatment and mutation with specific genotype HBV, we have established a new genotyping strategy fragment HBV DNA polymerase Pairwise phylogenetic analyses were performed using CLUSTAL V (DNASTAR) standard full-length sequences from GenBank (NCBI)...
Purpose: To evaluate the efficacy and safety of nucleos(t)ide analogues, especially telbivudine (LdT) for prevention mother-to-child transmission (MTCT) hepatitis B virus (HBV) in women with high viremia.Methods: We conducted a prospective, open-label, multicenter study LdT treating pregnant having viral loads (HBV DNA>5 log10 IU/mL) but normal levels alanine aminotransferase (ALT).Maternal HBV DNA, serologic status ALT were measured at baseline, 4 weeks after therapy, before delivery, 12...
Individual food items and nutrients are associated with the development of nephrolithiasis.
Colorectal cancer is one of the most common primary malignancies and third cause death in both men women United States. Among people diagnosed with initial colorectal cancer, 22% had metastatic while 5-year survival rate was less than 20%. The purpose this study to develop a nomogram for predicting distant metastasis newly patients identify high-risk groups.We retrospectively reviewed data who were at Zhong nan Hospital Wuhan University People's Gansu Province between January 2016 December...
Objective: The proportion of hepatitis e antigen (HBeAg)-negative chronic B (CHB) patients in China has increased rapidly.However, the response these to peginterferon (peg-IFN) treatment is poor, and antiviral strategies are inconsistent.This study aimed investigate role virus (HBV) DNA surface (HBsAg) early prediction HBeAg-negative CHB receiving peg-IFN α-2a.Patients Methods: Treatment-naïve were involved this prospective during 2014-2018.The HBV HBsAg quantified at baseline (weeks 12, 24...
Background & aims: accumulating evidence shows that various sleep behaviors are related to metabolic dysfunction-associated fatty liver disease (MAFLD), and diet plays an important role in both preventing treating this condition. However, the overall effect of a healthy pattern its joint with on risk MAFLD remain unclear. The aim study is explore independent combined effects dietary patterns risk. Methods: population-based prospective cohort was conducted China sample size 13 687...