A5048440061- Hepatitis B Virus Studies
- Mobile Ad Hoc Networks
- Hepatitis C virus research
- Wireless Networks and Protocols
- RNA Research and Splicing
- Cooperative Communication and Network Coding
- Opioid Use Disorder Treatment
- Minerals Flotation and Separation Techniques
- Herpesvirus Infections and Treatments
- Hepatitis Viruses Studies and Epidemiology
- Cancer Research and Treatments
- Analytical chemistry methods development
- Cancer-related molecular mechanisms research
- Asthma and respiratory diseases
- Forensic Toxicology and Drug Analysis
- Magnetic and Electromagnetic Effects
- Allergic Rhinitis and Sensitization
- RNA modifications and cancer
- Dermatology and Skin Diseases
- Analytical Chemistry and Chromatography
- CRISPR and Genetic Engineering
- Belt Conveyor Systems Engineering
- Natural product bioactivities and synthesis
- Educational Technology and Pedagogy
- Animal Virus Infections Studies
Harbin Veterinary Research Institute
2020-2025
Chinese Academy of Agricultural Sciences
2020-2025
Shanghai Institute of Materia Medica
2004-2024
Chinese Academy of Sciences
2004-2024
Princeton University
2021-2024
Model Animal Research Center
2024
Nanjing University
2024
Beijing General Research Institute of Mining and Metallurgy
2010-2023
State Ethnic Affairs Commission
2021-2023
Southwest Minzu University
2021-2023
The systemic immune-inflammation index (SII) has been used as a prognostic marker for several cancer types, but there is no in-depth study in bladder cancer. This evaluated the potential utility of SII factor patients with after radical cystectomy.A retrospective analysis 209 who had undergone cystectomy and were randomized into primary (N=139) validation (N=70) cohorts was conducted. overall survival (OS) calculated using Kaplan-Meier curves. value analyzed by Cox regression model. A...
A major goal for the treatment of opioid use disorder is to reduce or eliminate illicit opioids. Buprenorphine, a μ-opioid receptor partial agonist and kappa antagonist, now being developed as monthly, sustained-release formulation (RBP-6000). The objective this study was demonstrate that RBP-6000 blocks subjective effects reinforcing efficacy hydromorphone (intramuscularly administered) in subjects with moderate severe disorder. Subjects were first inducted dose stabilized on sublingual...
The p53 mutation and altered Pten expression are two most common genetic events in Hepatitis B virus (HBV) infection related hepatocellular carcinoma (HCC). To confirm the causative role of somatic HCC development, we established CRISPR/Cas9-mediated gene disruption via hydrodynamic tail vein injection, allowing for vivo targeting simultaneously adult HBV transgenic mice. Here demonstrated that utility this approach resulted macroscopic liver tumors as early 4 months' post injection harbored...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) evolves rapidly under the pressure of host immunity, as evidenced by waves emerging variants despite effective vaccinations, highlighting need for complementing antivirals. We report that targeting a pyrimidine synthesis enzyme restores inflammatory response and depletes nucleotide pool to impede SARS-CoV-2 infection. deploys Nsp9 activate carbamoyl-phosphate synthetase, aspartate transcarbamoylase, dihydroorotase (CAD) catalyzes...
Chicken infectious anemia (CIA) is a highly contagious disease caused by the chicken virus (CIAV), and it poses serious threat to poultry industry. However, effective control measures strategies have not been identified. In this study, recombinant Marek's (rMDV) expressing VP1 VP2 proteins of CIAV was successfully constructed using CRISPR/Cas9, commercial (MDV) vaccine strain used as vector. expression rMDV confirmed immunofluorescence assay western blot analysis, which revealed robust in...
Human papillomavirus (HPV) infection is the most important risk factor for cervical cancer development. In HeLa cell line, HPV viral genome integrated at 8q24 in one allele of chromosome 8. It has been reported that fragment can cis-activate expression proto-oncogene MYC, which located 500 kb downstream site. However, underlying molecular mechanism this regulation unknown. A recent study MYC was highly expressed exclusively from HPV-integrated haplotype, and a long-range chromatin...
Nucleos(t)ide analogues (NAs) have been widely used for the treatment of chronic hepatitis B (CHB). Because viral DNA polymerase lacks proofreading function (3′ exonuclease activity), theoretically, incorporated NAs would irreversibly terminate synthesis. This study explored natures nascent virus (HBV) and infectivity progeny virions produced under NA treatment. HBV was determined by infection HepG2‐NTCP cells primary human hepatocytes (PHHs). Biochemical properties in were investigated...
Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a heterogeneous disease characterized by different clinical features and treatment responsiveness. This study aimed to compare the serum metabolomics profiles between eosinophilic CRSwNP (eCRSwNP) non-eosinophilic (neCRSwNP) healthy controls (HC) explore objective biomarkers for distinguishing eCRSwNP before surgery. Methods: Serum samples were collected from 33 neCRSwNP patients, 37 29 HC. investigated ultra-high-performance...
Marek's disease (MD), an immunosuppression induced by virus (MDV), is one of the significant diseases affecting health and productive performance poultry. The roles circular RNAs (circRNAs) in MD development were poorly understood. In this study, we found a circRNA derived from exon 6 RUNX family transcription factor 2 (RUNX2) gene, named circRUNX2.2, was highly expressed chicken tumorous spleens (TS) MDV. Through fluorescence situ hybridization nuclear-cytoplasmic separation assay,...
RBP-8000 is a double mutant cocaine esterase that rapidly metabolizes cocaine. This study was conducted to assess the pharmacokinetics of and cocaine-induced physiological effects in absence (placebo) or presence RBP-8000. Twenty-nine abusers were randomized 1:1 (active: placebo) 4 sequences 2 treatment periods. In RBP-8000, plasma exposures dropped by 90% within min; significantly reduced with higher extent faster decrease systolic blood pressure pulse rate compared placebo. provides strong...
SUMMARY The newly emerged SARS-CoV-2 caused a global pandemic with astonishing mortality and morbidity. mechanisms underpinning its highly infectious nature remain poorly understood. We report here that exploits cellular CTP synthetase 1 (CTPS1) to promote synthesis suppress interferon (IFN) induction. Screening expression library identified ORF7b ORF8 suppressed IFN induction via inducing the deamidation of regulatory factor 3 (IRF3). Deamidated IRF3 fails bind promoters classic...
The intrinsic flexibility and independence of infrastructure enable mobile ad hoc networks (MANET) to be widely used in various environments such as disaster rescue, battlefield. Recently, researches have shown that interference can impose a significant impact on the performance MANET. However, there is no unified definition MANETs currently. Therefore, this paper, we first introduce an explicit interference. Based definition, present series formulas for computing node-interference,...
A new, long-acting, subcutaneous (SC) formulation of risperidone (RBP-7000) has been developed for the treatment schizophrenia to address issues non-adherence associated with oral treatment. The objective this work was establish an exposure-response relationship between total active moiety (AM) plasma exposure (risperidone + 9-hydroxy-risperidone) and Positive Negative Syndrome Scale (PANSS) or Clinical Global Impression severity (CGI-S) scores using data from a registration trial.This Phase...
Two phase I studies assessed the pharmacokinetics of buprenorphine, its metabolite norbuprenorphine, and naloxone following administration buprenorphine/naloxone sublingual tablets in Chinese participants. In first I, open-label, single ascending-dose (SAD) study, 82 opioid-naïve volunteers received a dose ranging from 2 mg/0.5 mg to 24 mg/6 while under naltrexone block. second multiple (MAD) 27 patients with opioid dependence withdrawal doses either 16 mg/4 or for 9 consecutive days. Serial...
The aberrant expression of transcription factor Basonuclin (BNC) had been reported in different kinds tumors. Here, we investigated the and methylation status two homologs, BNC1 BNC2 hepatocellular carcinoma (HCC). We found that levels both were down-regulated HCC cell lines primary tissues. frequency intensity promoter hypermethylation tumor tissues was significantly higher than adjacent non-tumor 5-Aza-2'-Deoxycytidine treatment could increase methylated lines, which implicated epigenetic...
The aim of this study was to identify differences in serum metabolomics profiles house-dust-mite (HDM)-induced allergic rhinitis (AR) patients compared controls and explore novel biomarkers reflecting disease severity. Serum samples were collected from 29 healthy HDM-induced 72 AR patients, including 30 mild (MAR) 42 moderate severe (MSAR). Metabolomics detection performed, orthogonal partial least square discriminate analysis applied assess the between for subgroups based on These results...