A5030198338- Opioid Use Disorder Treatment
- Statistical Methods in Clinical Trials
- Antibiotics Pharmacokinetics and Efficacy
- Pain Management and Opioid Use
- Antibiotic Resistance in Bacteria
- Forensic Toxicology and Drug Analysis
- Drug Transport and Resistance Mechanisms
- Statistical Methods and Bayesian Inference
- Helminth infection and control
- Pharmacogenetics and Drug Metabolism
- Analytical Chemistry and Chromatography
- Pharmaceutical studies and practices
- Schizophrenia research and treatment
- Substance Abuse Treatment and Outcomes
- Pharmacological Effects and Toxicity Studies
- Diphtheria, Corynebacterium, and Tetanus
- Antimicrobial Resistance in Staphylococcus
- Antibiotic Use and Resistance
- Neutropenia and Cancer Infections
- Neuroscience of respiration and sleep
- Effects and risks of endocrine disrupting chemicals
- Statistical Methods and Inference
- Genetic Associations and Epidemiology
- Blood disorders and treatments
- Cannabis and Cannabinoid Research
Indivior (United States)
2015-2024
Indivior (United Kingdom)
2019
Toxalim Research Centre in Food Toxicology
2010-2016
University of Florida
2016
Columbus Oncology and Hematology Associates
2016
École Nationale Vétérinaire de Toulouse
2001-2014
Institut National Polytechnique de Toulouse
2011-2014
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2013-2014
Université Toulouse III - Paul Sabatier
2011-2012
Université de Toulouse
2010-2011
The transepithelial intestinal elimination of ivermectin was studied using the closed-loop model in rat. common bile duct cannulated, and duodenum, jejunum, ileum were isolated situ with their intact blood supplies. Following administration 100, 200, or 400 microg/kg b.wt. via carotid artery, parent into small lumen over 90 min approximately 5-fold higher than bile. major amount secreted recovered but duodenum showed a capacity other segments respect to length. Systemic coadministration...
Chronic opioid consumption is associated with addiction, physical dependence, and tolerance. Tolerance results in dose escalation to maintain the desired effect. Intake of high‐dose or potent opioids may cause life‐threatening respiratory depression, an effect that be reduced by We performed a pharmacokinetic‐pharmacodynamic analysis effects fentanyl chronic users opioid‐naïve subjects quantify tolerance depression. Fourteen individuals eight received escalating doses intravenous...
Background Opioid-induced respiratory depression driven by ligand binding to mu-opioid receptors is a leading cause of opioid-related fatalities. Buprenorphine, partial agonist, binds with high affinity but displays effects. The authors examined whether sustained buprenorphine plasma concentrations similar those achieved some extended-release injections used treat opioid use disorder could reduce the frequency and magnitude fentanyl-induced depression. Methods In this two-period crossover,...
BACKGROUND. Potent synthetic opioids, such as fentanyl, are increasingly abused, resulting in unprecedented numbers of fatalities from respiratory depression. Treatment with the high-affinity mu-opioid receptor partial agonist buprenorphine may prevent by reducing binding potent opioids to opioid receptor, limiting
Data from low and middle-income countries (LMICs) on multidrug-resistant microorganisms (MDROs) in intensive care units (ICUs) are scarce. Working several ICUs Argentina, we sought to estimate the prevalence characteristics of MDRO infections carbapenemase-producing Enterobacterales (CPE) colonization. Mortality associated with infection was also evaluated. The study a 24-hour point conducted 164 adult Argentina between 24 November 28 2023. main outcome in-ICU mortality secondary outcomes...
A retrospective study was performed on 649 horses admitted to the Clinic of Equine Internal Medicine (Utrecht University) for gastrointestinal colic. The aim this provide a better guideline determining prognosis in with Short- and long-term survival were evaluated, Cox regression analysis identify clinical clinicopathologic variables usable predict survival. Intestinal displacements strangulations most frequently diagnosed causes Regarding surgically treated horses, 54% discharged 88% these...
RBP-6000 is a novel sustained-release formulation of buprenorphine for the treatment opioid use disorder, which has been designed once-monthly (28 days) subcutaneous (SC) injections. A population pharmacokinetic (PK) model was developed to describe time course plasma concentrations after repeated SC injections at 50 mg, 100 200 or 300 mg in treatment-seeking opioid-dependent subjects previously on sublingual (Subutex(®) ) treatment. The μ-opioid receptor occupancy predicted using PK/PD Emax...
The purpose of this study was to develop a whole-body physiologically based pharmacokinetic (WB-PBPK) model for ciprofloxacin ICU patients, on only plasma concentration data. In next step, tissue and organ time profiles in patients were predicted using the developed model. WB-PBPK built non-linear mixed effects approach data from 102 adult intensive care unit patients. Tissue distribution coefficients (Kp) available literature used as informative priors. successfully characterized both...
Purpose Area under the curve (AUC) dosing is routinely carried out for carboplatin, but chosen target AUC values remain largely empirical. This multicenter pharmacokinetic-pharmacodynamic (PK-PD) study was performed to determine covariates involved in interindividual variability of carboplatin hematotoxicity that should be considered when choosing individual AUCs. Patients and Methods Three hundred eighty-three patients received as part established regimens. A semi-physiologic population...
ObjectivesTo explore different ciprofloxacin dosage regimens for the treatment of intensive care unit (ICU) patients with respect to clinical outcome and development bacterial resistance major Gram-negative pathogens.
BUP-XR (a.k.a. RBP-6000 or SUBLOCADE™) is an extended-release subcutaneous buprenorphine formulation for the treatment of opioid use disorder. was designed to provide sustained exposure throughout monthly dosing interval, at concentrations sufficient control all aspects disease (withdrawal, craving, and blockade subjective effects). To characterize population pharmacokinetics based on phase II III data evaluate whether target therapeutic were reached with regimens evaluated in program. The...
The severity of the ongoing opioid crisis, recently exacerbated by COVID-19 pandemic, emphasizes importance for individuals suffering from use disorder (OUD) to have access and receive efficacious, evidence-based treatments. Optimal treatment OUD should aim at blocking effects illicit opioids while controlling craving withdrawal facilitate abstinence promote recovery. present work analyses relationship between buprenorphine plasma exposure clinical efficacy in participants with moderate...
Abstract Objective —To determine pharmacodynamic cutoffs with pharmacokinetic-pharmacodynamic principles and Monte Carlo simulation (MCS) for use of amoxicillin in pigs to set interpretive criteria antimicrobial susceptibility testing. Sample —191 plasma disposition curves obtained from 21 IV, 104 IM, 66 PO administrations corresponding 2,098 concentrations. Procedures —A population model was developed IM administration. The MCS method then used determine, various dosage regimens, the...