Hepatocellular carcinoma (HCC) is still the most common cause of cancer-related mortality worldwide and accumulating studies report that HCC frequently linked to chronic inflammation. G-protein alpha-subunit (GNAS)-activating mutations have recently been reported form a rare subgroup inflammatory liver tumors. In this study, we investigated roles GNAS in inflammation-related progression its underlying mechanism.Lipopolysaccharides (LPS) diethylnitrosamine were employed stimulate cells an...

Undifferentiated embryonal sarcoma of the liver (UESL) is a rare malignancy originating from primary mesenchymal tissue. The clinical manifestations, laboratory tests, and imaging examinations disease lack specificity preoperative misdiagnosis rate high. overall prognosis poor survival low.To investigate diagnosis, treatment, UESL.We performed retrospective, single-center cohort study in Shengjing Hospital China Medical University, which central hospital northeast China. From 2005 to 2017,...

To investigate the protective effect and mechanism of alanyl-glutamine dipeptide (Ala-Gln) against hepatic ischemia-reperfusion injury in rats.Rats were divided into group C as normal control Group (n=16) G pretreatment (n=16). Rats intravenously infused with 0.9% saline solution Ala-Gln -enriched (2% glutamine) via central venous catheter for three days. Then all rats underwent warm ischemia 30 min followed by different periods reperfusion. Changes biochemical parameters,the content...

Acute liver damage is considered to be the major cause of mortality after massive hepatectomy. Prostaglandin E1 (PGE1) and somatostatin (SST) have been shown protect against hepatic injury rats partial However, precise mechanisms remain largely unknown. In this study, we examined effects PGE1, SST combination these two drugs on acute 90% We found that animal survival was improved when pretreated with PGE1 SST. Portal venous pressure (PVP), serum alanine aminotransferase (ALT) aspartate...

Armc8 (armadillo-repeat-containing protein 8) was proved to promote disruption of E-cadherin complex through regulating α-catenin degradation. In this study, we investigated expression in hepatocellular carcinoma using immunohistochemistry (IHC). The positive rate 53.9 % and higher than that normal hepatic tissues (9.2 %) (p < 0.05). Clinicopathological analysis shows significantly associated with larger tumor size (≥5 cm), multiple numbers, pathological grade (media poor), advanced TNM...

&lt;b&gt;&lt;i&gt;Objective:&lt;/i&gt;&lt;/b&gt; To ascertain whether glutamine (Gln) pretreatment protects rats with obstructive jaundice from hepatic ischemia/reperfusion (I/R) injury and to determine the underlying molecular mechanisms. &lt;b&gt;&lt;i&gt;Methods:&lt;/i&gt;&lt;/b&gt; An rat model was developed by bile duct ligation. On first day after operation, all were randomized into two groups received oral Gln or normal saline (NS) daily for 7 days. Then both underwent a 15-min liver...

Abstract Adult primary undifferentiated embryonal sarcoma of the liver (UESL) is a rare disease. While etiology UESL remains largely unknown, association with systemic inflammatory disorders has been observed. Here, we report case in 46-year-old woman lupus erythematosus (SLE) and without chronic hepatitis or cirrhosis. Systematic review publicly available English language medical literature identified only 27 cases patients aged &gt;45 years none SLE. Our patient presented abdominal pain...

BACKGROUND This study investigated the effect of 70% portal vein ligation (PVL), a widely used procedure for inducing rapid liver regeneration, on expression autophagy-related proteins in non-ligated lobes rats. MATERIAL AND METHODS Rats were subjected to either sham (n=30, major branches exposed but kept intact) or PVL double-ligated) operations. Liver samples collected 12, 24, 48, 72, and 168 h after operation. volume, color, percentage, expressions light chain (LC) 3, beclin 1, cyclin D1...

Background/Aims . Hepatic ischemia-reperfusion (I/R) injury is a serious concern during hepatic vascular occlusion. The objectives of this study were to assess effects three techniques for occlusion on I/R and explore the underlying mechanisms. Methods Liver cirrhotic rats had undertaken Pringle maneuver (PR), hemihepatic (HH), or blood inflow without artery control (WH). Levels tumor necrosis factor alpha (TNF- α ), nuclear kappa B (NF- κ B), toll-like receptor 4 (TLR4),...

Abstract Background Resection of a retrocaval paraganglioma is technically challenging due to limited tumor accessibility and proximity the vena cava. Case presentation A large, malignant was found behind retrohepatic segment inferior cava 60-year-old male. During resection this rare paraganglioma, left lateral lobe liver, portion caudate gallbladder were also removed. Unfortunately, patient died six months after surgery hepatic metastasis. Conclusion This case demonstrates that partial...

Purpose: In this study, we evaluated the efficacy of microwave ablation-assisted laparoscopic hepatectomy (MLH) for management hepatocellular carcinoma (HCC) in cirrhotic patients.Methods: Data from HCC patients with liver cirrhosis who underwent (LH) or MLH Shengjing Hospital (Shenyang, China) were retrospectively analyzed January 2013 to June 2017. The demographic characteristics, clinical features, intraoperative parameters and surgical outcomes compared. Propensity scores matching (PSM)...

Background: To investigate the value and significance of modified Pringle method in liver resection treatment for hepatocellular carcinoma (HCC). Methods: In this retrospective observational study, we analyzed 94 cases HCC treated with hepatic our department between January 2006 November 2013. The patients were divided into two groups by blood flow occlusion used (modified Pringle, 56 cases; 38 cases). following data collected: intraoperative loss; transfusion volume (including red cells...

This study aimed to assess whether a single dose of ertapenem prophylaxis was more effective than other antibiotics prevent surgical site infection (SSI) after selective hepatectomy for hepatocellular carcinoma (HCC).The data from HCC patients with open between January 2012 and June 2017 in Shengjing Hospital were retrospectively analyzed. These divided into two groups: (ER) group, where ER administered; non-ertapenem (NER) NER administered. The SSI rates compared groups before matching the...

Background: To investigate the value and significance of modified Pringle method in liver resection treatment for hepatocellular carcinoma (HCC).