A5030831916- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- RNA Research and Splicing
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Immune cells in cancer
- Cancer, Lipids, and Metabolism
- Vascular Tumors and Angiosarcomas
- HIV-related health complications and treatments
- Cardiac tumors and thrombi
- CAR-T cell therapy research
- Hepatocellular Carcinoma Treatment and Prognosis
- Medical Research and Treatments
- Dietary Effects on Health
- Cytokine Signaling Pathways and Interactions
- MRI in cancer diagnosis
- Radiomics and Machine Learning in Medical Imaging
- Ferroptosis and cancer prognosis
- Immune Cell Function and Interaction
- Phagocytosis and Immune Regulation
- Clinical Nutrition and Gastroenterology
- Epigenetics and DNA Methylation
- interferon and immune responses
- Moringa oleifera research and applications
- Cancer-related gene regulation
China Medical University
2018-2024
Sheng Jing Hospital
2018-2023
First Hospital of China Medical University
2021
Hepatocellular carcinoma (HCC) is still the most common cause of cancer-related mortality worldwide and accumulating studies report that HCC frequently linked to chronic inflammation. G-protein alpha-subunit (GNAS)-activating mutations have recently been reported form a rare subgroup inflammatory liver tumors. In this study, we investigated roles GNAS in inflammation-related progression its underlying mechanism.Lipopolysaccharides (LPS) diethylnitrosamine were employed stimulate cells an...
Hepatocellular carcinoma (HCC) is still the most common cause of tumor-related death worldwide and accumulating studies report that long non-coding RNAs (LncRNAs) are closely related with HCC development, metastasis prognosis. Cisplatinum, a well-known chemotherapeutic drug, has been widely used for treatment numerous human cancers including HCC. This study aimed to investigate differential expressions LncRNAs in cells treated cisplatinum its underlying mechanism.The were determined by...
Background Cancer-associated fibroblasts (CAFs) are essential components of the tumor microenvironment (TME). These cells play a supportive role throughout cancer progression. Their ability to modulate immune system has also been noted. However, there limited investigation CAFs in TME epithelial ovarian (EOC). Methods We comprehensively evaluated CAF landscape and its association with gene alterations, clinical features, prognostic value, cell infiltration at pan-cancer level using...
Dysregulation of fatty acid (FA) metabolism is involved in hepatocellular carcinoma (HCC) development. Non-POU domain-containing octamer binding protein (NONO), known as the component nuclear paraspeckles, has recently been found to promote HCC progression. In this study, we investigated functions NONO regulating de novo FA synthesis and its underling mechanism during development.The roles development by applying gene function loss analysis cells were detected quantitative real-time...
Background & AimsHepatocellular carcinoma (HCC) is the most common type of hepatic malignancies, with poor prognosis and low survival rate. Paraspeckles, which are unique subnuclear structures, recently found to be involved in development various tumors, including HCC, related induction chemoresistance HCC. This study aimed investigate possibility paraspeckle HCC cells participating immune escape its underlying mechanism vitro vivo.MethodsExpression NEAT1_2, framework paraspeckle, tissues...
Primary cardiac angiosarcoma (PCAS) is a rare and aggressive heart tumour with limited treatment options poor prognosis. Understanding cellular heterogeneity microenvironment (TME) crucial for the development of effective therapies. Here, we investigated intratumoural TME diversity PCAS using single-cell RNA sequencing (scRNA-seq).
To investigate the correlation between contrast-enhanced ultrasound parameters and hepatic venous pressure gradient (HVPG), to develop a new noninvasive method for evaluation of portal hypertension in patients with decompensated liver cirrhosis.One-hundred cirrhosis were examined by ultrasound, dynamic images collected offline analysis. The contrast arrival time was obtained artery (HA), vein (PV), (HV), HA-HV transit (HA-HVTT) PV-HV (PV-HVTT) calculated. At same time, HVPG measured within...
The prevention and treatment of posthepatectomy liver failure (PHLF) is a difficult problem for hepatectomy. PHLF characterized by many risk factors, limited methods high mortality. There are factors that lead to the insufficient quantity or quality postoperative remnant cells, such as comorbid conditions patients, underlying disease liver, excessive resection so on, which increase incidence PHLF. However, therapeutic at present, key reduce morbidity mortality lies in accurate evaluation...
Objective To investigate the perioperative risk factors for posthepatectomy liver failure (PHLF) in patients with hepatocellular carcinoma(HCC). Methods Data of 322 cases resection HCC were retrospectively analyzed from Sep 2013 to 2018. Logistic regression was used analyze PHLF. The receiver operating characteristic (ROC) curve predictive power ALBI score and Child-Pugh PHLF. Results Child-Pugh score, intraoperative bleeding amount, ICG R15 fibrosis, peritoneal effusion...
<h3>Background</h3> The aim of this study was to develop and externally validate a prognostic model for survival in people living with HIV/AIDS (PLWHA) initiating ART based on two large population-based cohorts China. <h3>Approach</h3> derivation cohort consisted PLWHA treated between February 2004 December 2019 tertiary center Guangzhou, South China, validation patients 2018 another hospital Shenyang, Northeast We assessed 20 candidate predictors an endpoint death from all causes. developed...