Rapidly sharing scientific information is an effective way to reduce public panic about COVID-19, and doing so the key providing real-time guidance epidemiologists working contain outbreak, clinicians managing patients, modelers helping understand future developments possible effectiveness of various interventions. This issue has rapidly reviewed published articles describing including drug treatment options for SARS-CoV-2, its clinical characteristics, therapies involving a combination...

MicroRNAs (miRNAs) are small noncoding RNAs whose function as modulators of gene expression is crucial for the proper control cell growth. Although many microRNAs were found to express in central nervous system (CNS), role regulatory networks which they involved and their pathological process nerve cells only just emerging. In present study, possible mechanisms by one neuronal miRNAs, miR-125b, affected growth investigated using vitro line model.The pattern miR-125b ATRA-treated human glioma...

The aging of a population structure is an inevitable path demographic transition, as inescapable result decline in fertility rate and extension life expectancy. Although transition occurred earlier Japan than China, the two countries had similar patterns, both which took much shorter period time Western to complete well have been at rapid speed that has rarely seen world. highest level world, China experiencing very fast pace process largest older population. Drawing upon data from World...

To assess the effectiveness of response strategies avoiding large gatherings or crowded areas and to predict spread COVID-19 infections in Japan, we developed a stochastic transmission model by extending Susceptible-Infected-Removed (SIR) epidemiological with an additional modeling individual action on whether stay away from areas. The population were divided into three compartments: Susceptible, Infected, Removed. Susceptible transitions Infected every hour probability determined ratio...

Japan is experiencing unprecedented aging of its population. People age 65 years or older accounted for 28.1% the total population in 2018, and that proportion expected to reach 33.3% 2036 38.4% 2065. In 2017, average life expectancy was 81.09 men 87.26 women. By 2065, it 84.95 91.35 Population affects health long-term care systems. The government proposed establishment "a community-based integrated system" by 2025 with purpose comprehensively ensuring provision care, nursing preventive...

RNA binding proteins (RBPs) dysregulation have been reported in various malignant tumors and associated with the occurrence development of cancer. However, role RBPs lung adenocarcinoma (LUAD) is poorly understood. We downloaded sequencing data LUAD from Cancer Genome Atlas (TCGA) database determined differently expressed between normal cancer tissues. The study then systemically investigated expression prognostic value these by a series bioinformatics analysis. A total 223 were identified,...

Abstract Background Efforts to precisely assess tumor-specific T-cell immune responses still face major challenges, and the potential molecular mechanisms mediating hepatocellular carcinoma (HCC) microenvironment imbalance after incomplete radiofrequency ablation (iRFA) are unclear. This study aimed provide further insight into integrated transcriptomic proteogenomic landscape identify a new target involved in HCC progression following iRFA. Methods Peripheral blood matched tissue samples...

Over the past few years, Chinese Government has paid greater attention to rare diseases and it incorporated in national health strategy planning. On May 22, 2018, officially released its first list of diseases, which included 121 diseases. The was published facilitate societal awareness improve ability front-line medical staff treat introduce incentives for research development orphan drugs, increase availability medicines This effort will enhance management China, raise level diagnosis...

On July 11, 2017, the State Council of China issued a bold plan to revolutionize medical education and promote collaboration between practice. The cornerstone is training more qualified professionals improve public healthcare on path Healthy 2030. According this plan, "5+3" system will be instituted train in China, top colleges encouraged recruit students. However, given less-than-ideal professional status Chinese doctors, frequent incidents violence against them, long working hours heavy...

On November 28th, 2019, the National Healthcare Security Administration (NHSA) and Ministry of Human Resources Social (MOHRSS) China announced results drug pricing negotiations. Seventy first-negotiated drugs with 60.7% average price decrease twenty-seven re-negotiated medicines 26.4% fall, involving 11 disease categories, were successfully incorporated into Reimbursement Drug List (NRDL). Medicines that get accessed to NRDL are mostly new listings high clinical value, more than half them...

In order to deepen the health system reform and improve mechanism for formation of drug prices, in January 2019, General Office State Council People's Republic China issued "National centralized purchasing using pilot program", selected 11 cities mainland carry out "4+7" city volume based work. This paper introduces specific implementation plan, organizational structure selection process China's volume-based work, expounds initial effects, existing problems policy development after policy....

Antibiotics are medicines used to prevent and treat bacterial infections. Antibiotic resistance occurs when bacteria change in response the use of these medicines. is rising dangerously high levels all parts world, leading higher medical costs, prolonged hospital stays, increased mortality. In European Union alone, drug-resistant estimated cause 25,000 deaths cost more than US$1.5 billion every year healthcare expenses productivity losses. The problems antibiotic misuse quite serious China....

Alzheimer's disease (AD) is a neurodegenerative disorder that affects millions worldwide and expected to surge in prevalence due aging populations. Frailty, characterized by muscle function decline, becomes more prevalent with age, imposing substantial burdens on patients caregivers. This paper aimed comprehensively review the current literature AD coupled frailty, encompassing prevalence, screening, assessment, treatment while delving into field's challenges future trajectories. Frailty...

Studies have found that intermittent fasting (IF) can prevent diabetes, cancer, heart disease, and neuropathy, while in humans it has helped to alleviate metabolic syndrome, asthma, rheumatoid arthritis, Alzheimer's many other disorders. IF involves a series of coordinated hormonal changes maintain the organism's balance cellular homeostasis. More importantly, activate hepatic autophagy, which is important for maintaining homeostasis energy balance, quality control, cell tissue remodeling,...

Diagnosis-related groups (DRG) based hospital payment systems are gradually becoming the main mechanism for reimbursement of acute inpatient care. We reviewed existing literature to ascertain global use DRG-based systems, compared similarities and differences original DRG versions in ten countries, used ischemic stroke as an example design implementation strategies various systems. The current challenges with direction development also analyzed. found that vary greatly countries terms their...

Japan has experienced five waves of the COVID-19 pandemic so far. Four states emergency were declared, and Tokyo 2020 Olympic (July 23-August 8, 2021) Paralympic Games (August 24-September 5, held during fifth wave pandemic. Although a record 5,773 new cases reported in on August 13, number abruptly decreased afterwards, only 9 confirmed November 1, 2021. The high vaccination rates (79.2% total population received first dose 77.8% second as December 24, behavioral changes (such mask wearing...