A5085866935- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Olfactory and Sensory Function Studies
- Biochemical Analysis and Sensing Techniques
- Neurobiology and Insect Physiology Research
- Alzheimer's disease research and treatments
- Neural dynamics and brain function
- Autonomous Vehicle Technology and Safety
- Advanced Chemical Sensor Technologies
- Effects of Vibration on Health
- IPv6, Mobility, Handover, Networks, Security
- Advanced Wireless Network Optimization
- Optical Coherence Tomography Applications
- Wireless Networks and Protocols
- Photoacoustic and Ultrasonic Imaging
- Wireless Power Transfer Systems
- Energy Harvesting in Wireless Networks
- Mitochondrial Function and Pathology
- Network Traffic and Congestion Control
- Neurogenesis and neuroplasticity mechanisms
- Software-Defined Networks and 5G
- Electron and X-Ray Spectroscopy Techniques
- Sleep and Wakefulness Research
- Time Series Analysis and Forecasting
- Ergonomics and Musculoskeletal Disorders
University of California, Irvine
2016-2024
Japan Science and Technology Agency
2017-2020
Ritsumeikan University
2016-2017
Norwegian University of Science and Technology
2011-2015
The University of Tokyo
2004-2012
RIKEN
2009-2011
NTNU Samfunnsforskning
2011
Tokyo Medical University
2011
RIKEN Center for Brain Science
2010
NTT (Japan)
2003-2007
Odor signals are conveyed from the olfactory bulb to cortex (OC) by mitral cells (MCs) and tufted (TCs). However, whether how two types of projection neuron differ in function axonal connectivity is still poorly understood. responses patterns were compared between MCs TCs mice visualizing axons electrophysiologically identified single neurons. demonstrated shorter onset latency for reliable than MCs. The response was maintained a wide range odor concentrations, whereas responded only strong...
In the past decade, much has been elucidated regarding functional organization of axonal connection olfactory sensory neurons to bulb (OB) glomeruli. However, manner in which projection OB process odorant input and send this information higher brain centers remains unclear. Here, we report long-range, large-scale tracing patterns using two-photon microscopy. Tracer injection into a single glomerulus demonstrated widely distributed mitral/tufted cell projections on lateroventral surface mouse...
The entorhinal cortex (EC) has bidirectional connections with the hippocampus and plays a critical role in memory formation retrieval. EC is one of most vulnerable regions brain early stages Alzheimer's disease (AD), neurodegenerative progressive impairments. Accumulating evidence from healthy behaving animals indicates gamma oscillations (30–100 Hz) as for mediating interactions circuit between hippocampus. However, it still unclear whether have causal relationship impairment AD. Here we...
Mitral and tufted cells are the projection neurons in olfactory bulb, conveying odour information to various regions of cortex. In spite their functional importance, there few molecular genetic tools that can be used for selective labelling or manipulation mitral cells. Tbx21 was first identified as a T-box family transcription factor regulating differentiation function T lymphocytes. brain, is specifically expressed bulb.In this study, we performed promoter/enhancer analysis mouse gene by...
Abstract The olfactory bulb (OB) transforms sensory input into spatially and temporally organized patterns of activity in principal mitral (MC) middle tufted (mTC) cells. Thus far, the mechanisms underlying odor representations OB have been mainly investigated MCs. However, experimental findings suggest that MC mTC may encode parallel complementary representations. We analyzed functional roles these pathways by using a morphologically physiologically realistic three-dimensional model to...
The glomerular sheet of the olfactory bulb (OB) forms odorant receptor maps that are parceled into zones. We previously reported molecular receptive range (MRR) property individual glomeruli in dorsal zone (zone 1) OB and showed polar functional groups play a major role activating this zone. However, MRR zones 2-4 is not well understood yet. Using method intrinsic signal imaging, we recorded odorant-induced activity from ventrolateral surface (zones 2-4) rat OB. While hydrocarbon odorants...
We investigate the uniqueness of driver behavior in vehicles and possibility using it for personal identification with objectives achieving safer driving, assisting case emergencies, being a part multi-mode biometric signature identification. use Gaussian mixture models (GMM) modeling individualities accelerator brake pedal pressures, focus on not only static features, but also dynamics pressures. Experimental results show that dynamic features significantly improve performance
Clinical evidence suggests that the entorhinal cortex is a primary brain area triggering memory impairments in Alzheimer’s disease (AD), but underlying circuit mechanisms remain largely unclear. In healthy brains, sharp-wave ripples (SWRs) hippocampus and play critical role consolidation. We tested SWRs MEC layers 2/3 of awake amyloid precursor protein knock-in (APP-KI) mice, recorded simultaneously with hippocampal CA1. found MEC→CA1 coordination SWRs, previously was disrupted APP-KI mice...
In this paper, we propose a driver identification method that is based on the driving behavior signals are observed while following another vehicle. Driving signals, such as use of accelerator pedal, brake vehicle velocity, and distance from in front, measured using simulator. We compared rate obtained different models features. As result, found nonparametric better than parametric models. Also, driver's operation were to be road environment car signals. The for thirty actual city area was 73%.
Since the discovery of odorant receptors (ORs) in rodents, most ORs have remained orphan receptors. Even for deorphanized vitro, their vivo properties are largely unknown. Here, we report odor response profiles two highly homologous mouse ORs, MOR29A and MOR29B, both vitro. The BAC transgenic was generated, which olfactory sensory neurons (OSNs) expressing transgenes MOR29B were differently tagged with IRES-gapECFP IRES-gapEYFP, respectively. MOR29A- MOR29B-expressing OSN axons converged on...
Here, we report in vivo 3-D visualization of the layered organization a rat olfactory bulb (OB) by swept source optical coherence tomography (SS-OCT). The SS-OCT operates at wavelength 1334 nm with respective theoretical depth and lateral resolutions 6.7 μm 15.4 air hence it is possible to get 3D structural map OB micron level resolution millimeter-scale imaging depth. Up until now, methods such as MRI, confocal microscopy, structure had not been clearly visualized these do satisfy criterion...