A5100693252- Natural product bioactivities and synthesis
- Inhalation and Respiratory Drug Delivery
- Phytochemistry and Biological Activities
- Genomics, phytochemicals, and oxidative stress
- Bioactive natural compounds
- Phytochemical compounds biological activities
- Neuroinflammation and Neurodegeneration Mechanisms
- Traditional and Medicinal Uses of Annonaceae
- Mitochondrial Function and Pathology
- Bioactive Compounds and Antitumor Agents
- Microbial Natural Products and Biosynthesis
- Liver Disease Diagnosis and Treatment
- Spondyloarthritis Studies and Treatments
- Autoimmune and Inflammatory Disorders Research
- Seaweed-derived Bioactive Compounds
- Medicinal Plants and Neuroprotection
- Chemical synthesis and alkaloids
- Medicinal Plant Research
- Pharmacological Effects of Natural Compounds
- Tannin, Tannase and Anticancer Activities
- Biological and pharmacological studies of plants
- Telomeres, Telomerase, and Senescence
- Cancer Research and Treatments
- Alkaloids: synthesis and pharmacology
- Psoriasis: Treatment and Pathogenesis
Chonnam National University
2018-2025
Chonnam National University Hospital
2023
Korea Research Institute of Bioscience and Biotechnology
2020
Virginia Tech
2017-2018
Target (United States)
2015-2017
National Cancer Institute
2015-2017
Center for Cancer Research
2015-2017
Seoul National University
2011-2016
The aim of this study was to investigate the potential anti-cancer effects probiotic cell-free supernatant (CFS) treatment using Lactobacillusfermentum for colorectal cancer (CRC) in 3D culture systems. Cell viability assessed MTS (3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium, inner salt) assays, whereas apoptosis monitored through RT-qPCR analysis Bax, Bak, Noxa, and Bid mRNA expressions addition flow cytometry Lactobacillus (LCFS) treatment. Our...
Recent studies found that short-chain fatty acids (SCFAs), which are produced through bacterial fermentation in the gastrointestinal tract, have oncoprotective effects against cervical cancer. The most common SCFAs well known include acetic acid, butyric and propionic among acid (PA) has been reported to induce apoptosis HeLa cells. However, mechanism suppress cell viability remain poorly understood. Our study aims provide a more detailed look into of PA Flow cytometry analysis revealed...
Natural products can serve as one of the alternatives, exhibiting high potential for treatment and prevention COVID-19, caused by SARS-CoV-2. Herein, we report a screening platform to test antiviral efficacy natural product library against SARS-CoV-2 verify their activity using lung organoids. Since is classified risk group 3 pathogen, drug assay must be performed in biosafety level (BSL-3) laboratory. To circumvent this limitation, pseudotyped viruses (PVs) have been developed replacements...
Polydatin (3,4',5-trihydroxy-3-β-d-glucopyranoside, PD) is known for its antioxidant and anti-inflammatory properties. Oxaliplatin (OXA)-based chemotherapy the first-line treatment metastatic recurrent colorectal cancer (CRC). However, lack of selectivity normal cells often results in side effects. Consequently, search anti-cancer components with high efficacy low cytotoxicity has become a significant focus recent years. The anti-tumor effects PD, OXA or their combination were assessed by...
Chromatographic purification of a methanol extract the roots Lespedeza bicolor led to isolation four new pterocarpans (1–4), two coumestans (6 and 7), arylbenzofurans (8 9), known pterocarpan 1-methoxyerythrabyssin II (5). Their structures were identified using NMR spectroscopy, UV mass spectrometry. Cytotoxicity assays showed that compounds 1–9 exerted antiproliferative effects on blood cancer cells. Of these compounds, 1 6 induced mitochondrial depolarization apoptosis in Jurkat These...
Compared to other organs, the brain has limited antioxidant defenses. In particular, hippocampus is central region for learning and memory highly susceptible oxidative stress. Glial cells are most abundant in brain, sustained glial cell activation critical neuroinflammation that aggravates neuropathology neurotoxicity. Therefore, regulating a promising neurotherapeutic treatment. Quinic acid its derivatives possess anti-oxidant anti-inflammatory properties. Although previous studies have...
Breast cancer is now the most common type of worldwide, surpassing lung cancer. This issue further worsened by lack effective therapies for disease. Recent reports indicate that inhibition ubiquitin-like modifier-activating enzyme 5 (UBA5) can impede tumor development. However, there have been few regarding UBA5-inhibiting compounds. work studied usenamine A, a natural product from lichen Usnea longissimi exhibits UBA5-inhibitory effects. Bioinformatics analysis was performed using public...
Prolonged exposure to fine dust (FD) increases the risk of skin inflammation. Stimulated epidermal cells release growth factors into their extracellular environment, which can induce inflammation in dermal cells. Algae are considered rich sources bioactive materials. The present study emphasized effect low-molecular-weight fucoidan isolated from Sargassum confusum (LMF) against FD-induced HaCaT keratinocytes and underneath fibroblasts (HDFs) an integrated culture model. HDFs were treated...
Abstract Alzheimer’s disease (AD) is a neurodegenerative induced by cholinergic neuron damage or amyloid-beta aggregation in the basal forebrain region and resulting cognitive disorder. We previously reported on neuroprotective effects of Betula platyphylla bark (BPB) an amyloid-beta-induced amnesic mouse model. In this study, we obtained cognitive-enhancing compound assessing results using scopolamine-induced Our show that oral treatment mice with BPB betulin significantly ameliorated...
Differentially expressed genes (DEGs) have been previously identified using massive parallel RNA sequencing in matched normal, breast cancer (BC) and nodal metastatic tissues. Squalene epoxidase (SQLE), one of these DEGs, is a key enzyme cholesterol synthesis. The aim the present study was to investigate potential involvement SQLE tumorigenic process BC determine its association with clinical outcome BC. mRNA expression measured reverse transcription‑quantitative PCR 10 pairs ductal...
It is well known that activated microglia produce nitric oxide (NO), which has an important role in the pathophysiology of several neurodegenerative diseases such as Alzheimer's disease. In course searching for novel therapeutic agents from medicinal plants against neuroinflammatory diseases, methanolic extract Tetrapanax papyriferus was found to have significant NO inhibitory activity lipopolysaccharide (LPS)-stimulated BV2 cells. Nine oleanane-type triterpenes, including two new compounds,...