A5100454639- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Phytochemical compounds biological activities
- Plant-derived Lignans Synthesis and Bioactivity
- Phytochemistry and Bioactive Compounds
- Traditional and Medicinal Uses of Annonaceae
- Plant biochemistry and biosynthesis
- Pharmacological Effects of Natural Compounds
- Marine Sponges and Natural Products
- Sirtuins and Resveratrol in Medicine
- Phytochemicals and Antioxidant Activities
- Natural Antidiabetic Agents Studies
- Bioactive Compounds and Antitumor Agents
- Biological Activity of Diterpenoids and Biflavonoids
- Phytochemical Studies and Bioactivities
- Phytochemistry and biological activity of medicinal plants
- Sesquiterpenes and Asteraceae Studies
- melanin and skin pigmentation
- Essential Oils and Antimicrobial Activity
- Cholinesterase and Neurodegenerative Diseases
- Bioactive natural compounds
- Skin Protection and Aging
- Ion Channels and Receptors
- Cynara cardunculus studies
- Chromatography in Natural Products
Yonsei University
2016-2025
Massachusetts Institute of Technology
2023
Inha University
2012-2014
Seoul National University
2003-2010
Elcom (Czechia)
2010
Sejong University
2009
Jeonju University
2009
The Mediator complex of Saccharomyces cerevisiae is required for diverse aspects transcription by RNA polymerase II (pol II). composed two functionally distinct subcomplexes, Rgr1 and Srb4. To identify the structures functions each subcomplex, we expressed recombinant proteins subunit assayed their interactions with other basal proteins. subcomplex Gal11 module, which binds activators, Med9/10 module. module both transcriptional activation repression, these activities appear to be carried...
Abstract A methanolic extract of dried Schisandra fruit ( chinensis Baill.; Schisandraceae) significantly attenuated the neurotoxicity induced by L‐glutamate in primary cultures rat cortical cells. Five dibenzocyclooctadiene lignans (deoxyschisandrin, gomisin N, A, schisandrin, and wuweizisu C) were isolated from extract; their protective effects against glutamate‐induced then evaluated. Among five lignans, deoxyschisandrin, C as measured 1) an inhibition increase intracellular [Ca 2+ ]; 2)...
Omija (Schizandra chinensis) is used as an ingredient in traditional medicine East Asia. It consumed tea and wine display pinkish-red color beneficial physiological activity. However, the origin of Omija's unique bioactivity has not been studied extensively its application very limited. Thus, it was required to determine chemical structure major phenolic compounds fruit evaluate their antioxidant The colorants extracted from a domestic cultivar were concentrated by Sep-pak(R) Plus C(18)...
Brevilin A, which has anticancer activities against a range of cancers, is an abundant constituent the medicinal herb Centipeda minima (L.) A. Braun & Asch, also been reported to have activity breast cancer cells. However, C. and brevilin A human gastric yet be reported. In this study, we aimed evaluate cytotoxicity molecular basis underlying extracts (CMX) (AGS) We deduced potential targets mechanisms based on network pharmacology approach. CCND1, CDK4, BCL2L1 were identified as key genes...
Gastritis is a common disease worldwide that caused by various causes such as eating habits, smoking, severe stress, and heavy drinking, well Helicobacter pylori infections non-steroidal anti-inflammatory drugs. Cinnamomum cassia tropical aromatic evergreen tree commonly used natural medicine in Asia functional food ingredient. Studies have reported this species’ anti-obesity, anti-diabetic, cardiovascular suppression effects. We evaluated the potential effects of C. using drugs (NSAIDs),...
Rhinacanthus nasutus (L.) Kurz (Acanthaceae) is known as traditional medicine for the treatment of fungal and herpes virus infections. A new naphthoquinone racemate, rhinacasutone (1) together with seven compounds, rhinacanthone (2), rhinacanthins C, D, N, Q, E (3-7), heliobuphthalmin (8) were isolated from root R. nasutus. Their structures determined on basis extensive spectroscopic methods, including 1D-, 2D-NMR MS data. All compounds tested their antiviral activities against PR8, HRV1B,...
Metabolomics is a useful tool for comparing metabolite changes in plants. Because of its high sensitivity, metabolomics combined with high-resolution mass spectrometry (HR-MS) the most widely accepted tools. In this study, we compared metabolites pathogen-infected rice (Oryza sativa) control using an untargeted approach. We profiled features two groups liquid chromatography quadrupole time-of-flight (QTOF-MS) system. Twelve differentially induced infected were selected through multivariate...
Chinese chive (Allium tuberosum) is a medicinal food that cultivated and consumed mainly in Asian countries. Its various phytochemicals physiological effects have been reported, but only few are available for skeletal muscle cell proliferation. Herein, we isolated new compound, kaempferol-3-O-(6″-feruloyl)-sophoroside (1), along with one known flavonoid glycoside (2) six amino acid (3–8) compounds from the water-soluble fraction of shoot chive. The were identified using extensive...
Traditional Chinese medicines have attracted increasing interest as potential sources of novel drugs with a wide range biological and pharmacological activities. Annona glabra Linn (Annonaceae) is used in traditional medicine an anticancer drug. Phytochemical investigation this plant led to the isolation acetogenins, ent-kauranes, peptides, alkaloids. In addition, compounds exhibited anticancer, anti-HIV-reserve, antimalaria.Isolation, structure determination, cytotoxic activity evaluation...
In this study we examined the inhibition of hepatic dyslipidemia by Eucommia ulmoides extract (EUE). Using a screening assay for BAX determined that EUE regulates BAX-induced cell death. Among various death stimuli tested regulated palmitate-induced death, which involves lysosomal translocation. rescued V-ATPase, α-galactosidase, α-mannosidase, and acid phosphatase, effect was reversed bafilomycin, V-ATPase inhibitor. The active components EUE, aucubin geniposide, showed similar to through...
Tuberculosis (TB) is a chronic infectious disease caused by Mycobacterium tuberculosis (Mtb) and remains major health problem worldwide. Thus, identification of new more effective drugs to treat emerging multidrug-resistant TB (MDR-TB) reduce the side effects anti-TB drugs, such as liver toxicity other detrimental changes, urgently needed. In this study, develop novel candidate drug for treatment with few in host, we selected pasakbumin A isolated from Eurycoma longifolia (E. longifolia)...
Despite the excellent antimicrobial activity of aminoglycoside antibiotics, permanent inner ear damage associated with use these drugs has resulted in need to develop strategies address ototoxic risk given their widespread use. In a previous study, we showed that avocado oil protects hair cells from caused by neomycin. However, detailed mechanism which this protection occurs is still unclear. Here, investigated auditory cell-protective enhanced functional extract (DKB122). RNA sequencing...