A5100761865- Bioactive natural compounds
- Hearing, Cochlea, Tinnitus, Genetics
- Synthesis of Organic Compounds
- Treatment of Major Depression
- Vestibular and auditory disorders
- Wood Treatment and Properties
- Ion Channels and Receptors
- Pineapple and bromelain studies
- Metabolism, Diabetes, and Cancer
- Bladder and Urothelial Cancer Treatments
- Multicomponent Synthesis of Heterocycles
- Medicinal Plant Extracts Effects
- Agricultural and Financial Auditing
- Regional Development and Environment
- Drug-Induced Hepatotoxicity and Protection
- Natural Antidiabetic Agents Studies
- Sleep and related disorders
- Postharvest Quality and Shelf Life Management
- Nematode management and characterization studies
- Case Reports on Hematomas
- Plant responses to elevated CO2
- Plant-Microbe Interactions and Immunity
- Flowering Plant Growth and Cultivation
- Protease and Inhibitor Mechanisms
- Digitalization and Economic Development in Agriculture
Kyung Hee University
2020-2024
Kangwon National University
2020-2024
DongKook Pharmaceutical (South Korea)
2019-2023
Gyeongnam National University of Science and Technology
2013-2021
Pukyong National University
2016
Hallym University
2013-2015
University of Ulsan
2010
Dong-A University
2005
Yeungnam University
2002
Chugai Pharma (United States)
2000
This study sought to evaluate the effects of Phaseolus multiflorus var. albus Bailey extract (PM extract) and Pleurotus eryngii ferulae (PF on inhibition digestive enzymes confirm anti-obesity effect DKB-117 (a mixture PM PF in enzyme a mouse model obesity induced by high-fat diet. In vitro studies, have increased dose-dependent inhibitory activity α-amylase (Inhibitory concentration (IC50 value: 6.13 mg/mL)) pancreatic lipase value; 1.68 mg/mL), respectively. High-fat diet–induced obese...
Despite the excellent antimicrobial activity of aminoglycoside antibiotics, permanent inner ear damage associated with use these drugs has resulted in need to develop strategies address ototoxic risk given their widespread use. In a previous study, we showed that avocado oil protects hair cells from caused by neomycin. However, detailed mechanism which this protection occurs is still unclear. Here, investigated auditory cell-protective enhanced functional extract (DKB122). RNA sequencing...
The total synthesis of biologically active pyranoflavone natural products 1 and 2 was carried out starting from 2H-pyran. pyranochalcone products, lonchocarpin (9) 4-hydroxylonchocarpin (10), their derivatives 30-32 is described. This synthetic route also provides interesting materials such as β-tubaic acid (24), desmethyl isoencecalin (25), (27).
Sensorineural hearing loss (SNHL) is one of the most common causes disability, affecting over 466 million people worldwide. However, prevention or therapy SNHL has not been widely studied. Avocado oil shown many health benefits but it yet studied in regards to SNHL. Therefore, we aimed investigate efficacy avocado on vitro and vivo elucidate its mode action. For present study, used enhanced functional extract (DKB122). DKB122 led recovery otic hair cells zebrafish after neomycin-induced cell...
Early tumor detection is crucial for the prevention of colon cancer. Near-infrared fluorescence (NIRF) imaging using a target-activatable probe may permit earlier disease detection. Matrix metalloproteinases (MMPs) participate in tumorigenesis and growth. The aim this study was to determine whether NIRF an MMP-activatable can detect tumors at early stages.WE UTILIZED TWO MURINE COLON CANCER MODELS: sporadic cancer model induced by azoxymethane (AOM), colitis-associated combination AOM...
Reactive oxygen species (ROS) generation in tomato plants by Ralstonia solanacearum infection and the role of hydrogen peroxide (H2O2) nitric oxide bacterial wilt control were demonstrated. During disease development wilt, accumulation superoxide anion (O2−) H2O2 was observed lipid peroxidation also occurred leaf tissues. High doses H2O2and sodium nitroprusside (SNP) donor showed phytotoxicity to detached leaves 1 day after petiole feeding showing reduced fresh weight. Both SNP have vitro...
Persea americana Mill., Lauraceae, commonly known as the avocado, is native to tropical and subtropical regions, including Brazil. From leaves of P. americana, one previously undescribed flavonol glycoside (1) together with ten flavonoids (2–11), four megastigmane glycosides (12–15) two lignans (16–17) were isolated. Their structures determined by extensive spectroscopic methods 1D- 2D-nuclear magnetic resonance mass spectrometry data. This first investigation that reports lignan classes...
Objectives Nonresponse or a partial response to 1 more antidepressants is common and significant problem in clinical practice. Adjunctive therapy with atypical antipsychotics considered as of the next treatment options for such inadequate responses. The present trial evaluated efficacy safety aripiprazole an augmentation ongoing antidepressant monotherapy patients major depressive disorder (MDD) who have previously exhibited response. Methods This was 6-week prospective, multicenter,...
The efficacy of amoxicillin sodium for controlling field and experimental Streptococcus iniae S. parauberis infections in olive flounder (Paralichthys olivaceus) was evaluated after a single intramuscular administration. Furthermore, the minimal inhibitory concentrations (MIC) against 21 strains were determined. In addition, pharmacokinetics residue depletion investigated. Single doses at 20, 40, 80, 160 mg/kg b.w. fish significantly reduced cumulative mortality rates to 18.8-31.3% (P <...
The bordered pitting arrangements in the tracheids of Dahurian larch (DL) and Japanese (JL) growing Korea were studied using optical microscopy to gain insights into wood identification both species. Differences noted tracheid patterns between In juvenile wood, DL dominantly exhibited uniseriate along earlywood within a growth ring, whereas JL displayed biseriate at start earlywood, transitioning pitting. transition predominantly showed beginning, with end, while initially middle. mature...
Abstract The radial variation of rays within the stems Dahurian larch and Japanese growing in Korea was studied to obtain valuable information identify two species determine wood quality. Uniseriate ray height, fusiform number, spacing, epithelial cell number were investigated by optical microscopy. heights uniseriate numbers lower than those larch. had greater spacing wood. In both species, increased with increasing growth ring but then stabilized from a certain number. However, decreased...
Avocado oil is beneficial to human health and has been reported have effects on sensorineural hearing loss (SNHL). However, the compounds in avocado that affect SNHL not identified. In this study, we identified 20 from oil, including two new 18 known fatty acid derivatives, using extensive spectroscopic analysis. The efficacy of isolated for improving was investigated an ototoxic zebrafish model. compounds, namely (2R,4R,6Z)-1,2,4-trihydroxynonadec-6-ene...
We describe the molecular characterization of Cu,Zn superoxide dismutase (SOD1) gene Cordyceps militaris, which is one entomopathogenic fungi called a vegetable wasp and plant worm. The SOD1 C. militaris spans 922 bp consisted three introns four exons coding for 154 amino acid residues. deduced sequence cDNA showed 88% identity to Claviceps purpurea SOD1, 82% Neurospora crassa 75–64% sequences from other fungi. possesses typical metal binding ligands six histidines aspartic common fungal...
The primary aim of this non-inferiority study was to investigate the clinical effectiveness and safety generic escitalopram (Lexacure(®)) versus branded (Lexapro(®)) for patients with major depressive disorder (MDD).The present included 158 patients, who were randomized (1:1) receive a flexible dose (n=78) or (n=80) over 6-week single-blind treatment period. benefits in two groups evaluated using Montgomery-Åsberg Depression Rating Scale (MADRS), 17-item Hamilton (HDRS), Clinical Global...
Phaseolus multiflorus var. albus (Leguminosae), commonly known as "white kidney bean", is a twining perennial vine whose fruit has been used popular food worldwide owing to its high nutritional content, in terms of proteins, carbohydrates, fats, and vitamins. As part our ongoing study investigate novel bioactive components from various natural resources, phytochemical investigation the extract P. fruits resulted isolation three phenolic compounds (1-3) one dipeptide (4). The chemical...
Sensorineural hearing loss (SNHL), characterized by damage to the inner ear or auditory nerve, is a prevalent disorder. This study explores potential of Castanopsis echinocarpa (CAE) as therapeutic agent for SNHL. In vivo experiments were conducted using zebrafish and mouse models. Zebrafish with neomycin-induced ototoxicity treated CAE, resulting in otic hair cell protection an EC50 0.49 µg/mL index 1020. CAE treatment improved function protected cochlear sensory cells model after...
This study sought to investigate the antihyperuricemia efficacy and safety of DKB114 (a mixture Chrysanthemum indicum Linn flower extract Cinnamomum cassia extract) evaluate its potential as a dietary supplement ingredient. clinical trial was randomized, 12-week, double-blind, placebo-controlled study. A total 80 subjects (40 with an intake 40 that placebo) who had asymptomatic hyperuricemia (7.0–9.0 mg/dL serum uric acid) randomly assigned. No significant difference between placebo groups...
This corrects the article "Menadione Sodium Bisulfite-Protected Tomato Leaves against Grey Mould via Antifungal Activity and Enhanced Plant Immunity" in Volume 36 on page 335.
アカマツ (Pinus densiflora Sieb.et Zucc.) 苗木の針葉のガス交換とクロロフィル蛍光特性の日内変化を野外条件下で追跡し, 光合成の日中低下の機構について検討を行った。苗木の頂部に展開した当年葉を対象に, ガス交換とクロロフィル蛍光を測定した。好陽的・耐乾性的な特性を持つと予想されるアカマツにおいても, 夏の晴天日における真昼の強光と温度上昇に対する光合成の日中低下が見られた。この光合成の日中低下には, 気孔コンダクタンスおよび光化学系IIを介しての量子収率 (Delta;F/Fm') と電子伝達速度 (ETR) の低下が伴っていた。測定は充分な土壌水分下の苗木を対象に行われたため, 植物体の水分不足ではなく, 1) 葉温や水蒸気圧欠差の上昇に伴う気孔の閉鎖反応と, 2) 強光下での光化学系の活性低下が, 光合成の日中低下の複合的な原因と考えられた。このとき, 非光化学的な光エネルギー放散 (NPQ) が増大しており, 過剰な光エネルギーの発生を散逸する機構が働いていることが示唆された。
Hibiscus syriacus L. flower (HSF) is a food ingredient commonly used for tea, and previous animal studies have reported its sleep-promoting effect. This study aims to test the potential of HSF extract as functional that improves sleep in humans.Eighty participants with disturbances who meet inclusion/exclusion criteria will be enrolled this study. Since effect on considered rather than medicine, severe insomnia excluded from The randomly assigned or placebo groups 1:1 ratio. capsules look...
Abstract For see ChemInform in Full Text.