A5026096692- melanin and skin pigmentation
- Bioactive natural compounds
- Biochemical Analysis and Sensing Techniques
- Phytochemicals and Antioxidant Activities
- Calcium signaling and nucleotide metabolism
- Natural product bioactivities and synthesis
- Hearing, Cochlea, Tinnitus, Genetics
- Vestibular and auditory disorders
- Adipose Tissue and Metabolism
- Zebrafish Biomedical Research Applications
- Natural Antidiabetic Agents Studies
- Essential Oils and Antimicrobial Activity
- Protein Tyrosine Phosphatases
- Antimicrobial Peptides and Activities
- Ginseng Biological Effects and Applications
- Plant biochemistry and biosynthesis
- Neurobiology and Insect Physiology Research
- Oral microbiology and periodontitis research
- Food Quality and Safety Studies
- Pomegranate: compositions and health benefits
- Alcohol Consumption and Health Effects
- Healthcare and Venom Research
- Pharmacological Effects of Natural Compounds
- Bioactive Compounds and Antitumor Agents
- Diet, Metabolism, and Disease
Kyung Hee University
2018-2025
Prince of Songkla University
2024
Context: Traditional knowledge of herbal remedies plays an important role in the search for more effective alternative treatment a variety disorders. The ethnobotanical surveys southern Thailand have revealed that 35 Thai formulas been used by traditional healers against dental caries. However, scientific evaluation to confirm their rational uses is scarce.
Sensorineural hearing loss (SNHL) is one of the most common causes disability, affecting over 466 million people worldwide. However, prevention or therapy SNHL has not been widely studied. Avocado oil shown many health benefits but it yet studied in regards to SNHL. Therefore, we aimed investigate efficacy avocado on vitro and vivo elucidate its mode action. For present study, used enhanced functional extract (DKB122). DKB122 led recovery otic hair cells zebrafish after neomycin-induced cell...
Thai rejuvenating remedies are mixed herbal formulas promoting longevity. Due to the complexity, biological activities of these minimal. Therefore, in this study, authors evaluated anti-pigmentation effect at molecular level selected remedy fulfill knowledge gap. First, found that showed promising activity against tyrosinase enzyme with an IC50 value 9.41 µg/mL. In comparison, kojic acid (positive control) exhibited 3.92 µg/mL same enzyme. Later, identified glabridin as a bioactive molecule...
This study presents a phytochemical investigation of Lepionurus sylvestris leaf extracts and their anti-diabetic activities. Traditionally, L. leaves were used as vegetables food in local recipes, but the root plant can also be body tonic erectile dysfunction treatments. Following preliminary activity screening test, 80% ethanolic extract exhibited potent anti-alpha glucosidase activity. So, leaves’ active components selected for further investigation. Firstly, was extracted via maceration...
Sensorineural hearing loss (SNHL) is a common condition that results from the of function hair cells, which are responsible for converting sound into electrical signals within cochlea and auditory nerve. Despite prevalence SNHL, universally effective treatment has yet to be approved. To address this absence, present study aimed investigate potential therapeutic effects TS, combination Cuscutae Semen Rehmanniae Radix Preparata. end, both in vitro vivo experiments were performed evaluate...
Metabolic syndrome has become a global health care problem since it is rapidly increasing worldwide. The search for alternative natural supplements may have potential benefits obesity and diabetes patients. Diospyros kaki fruit extract its oligosaccharides, including gentiobiose, melibiose, raffinose, were examined their anti-insulin resistance obesity-preventing effect in zebrafish larvae. results show that D. oligosaccharides improved insulin high-fat-diet-induced larvae, evidenced by...
Pharmacognosy Magazine ,2019,15,65,708-714.DOI:10.4103/pm.pm_43_19Published:September 2019Type:Original Article Authors:Sukanya Dej-adisai, Kedsaraporn Parndaeng, Chatchai Wattanapiromsakul, Wanlapa Nuankaew, and Tong Ho Kang Author(s) affiliations:Sukanya Dej-adisai1, Parndaeng1, Wattanapiromsakul1, Nuankaew2, Kang2 1Department of Pharmaceutical Botany, Faculty Sciences, Prince Songkla University, Hat-Yai, Songkhla, Thailand 2Department Oriental Medicinal Biotechnology, Graduate School...
Insulin resistance, which occurs when insulin levels are sufficiently high over a prolonged period, causing the cells to fail respond normally hormone. As system for resistance and diabetes drug development, insulin-resistant rodent models have been clearly established, but there is limitation high-throughput screening. Recently, zebrafish identified as an excellent discovery identification of therapeutic targets, studies on not extensively performed. Therefore, we aimed make rapid model...
The circadian rhythm is the internal clock that controls sleep-wake cycles, metabolism, cognition, and several processes in body, its disruption has been associated with aging. differentiated embryo chondrocyte (Dec) gene related to rhythm. To our knowledge, there are no reports of relationship between dec expression KRG effect. Therefore, we treated Dec knockout (KO) aging mice study anti-aging effects possible mechanisms. We evaluated genes an ototoxicity model. livers was further...
Sensorineural hearing loss (SNHL), characterized by damage to the inner ear or auditory nerve, is a prevalent disorder. This study explores potential of Castanopsis echinocarpa (CAE) as therapeutic agent for SNHL. In vivo experiments were conducted using zebrafish and mouse models. Zebrafish with neomycin-induced ototoxicity treated CAE, resulting in otic hair cell protection an EC50 0.49 µg/mL index 1020. CAE treatment improved function protected cochlear sensory cells model after...
Tyrosinase is an important enzyme in the biosynthesis of melanin. Many skin-whitening agents that inhibit tyrosinase activity from natural sources have been identified because they are harmless and non-toxic. In this work, 114 samples 54 Fabaceae plants were assessed for their anti-tyrosinase using a dopachrome method. The results found
The EtOAc, n-BuOH, and aqueous fractions from the aerial parts of Malva verticillata have been shown to promote significant recovery alloxan-induced pancreatic islet (PI) damage in zebrafish larvae at 10 μg/mL. Therefore, this study aimed identify principal active components these plant their pharmacological properties. Repeated SiO 2 octadecyl column chromatography with M. led isolation four phenolic compounds; compounds were identified as benzyl-α-D-galactopyranoside (1),...