A5073905061- Dialysis and Renal Disease Management
- Cervical Cancer and HPV Research
- Advanced Radiotherapy Techniques
- Endometrial and Cervical Cancer Treatments
- Natural product bioactivities and synthesis
- Pancreatic function and diabetes
- Advances in Oncology and Radiotherapy
- Hearing, Cochlea, Tinnitus, Genetics
- Archaeological and Historical Studies
- Medieval Architecture and Archaeology
- Diabetes and associated disorders
- Diet, Metabolism, and Disease
- Glaucoma and retinal disorders
- Receptor Mechanisms and Signaling
- Ginseng Biological Effects and Applications
- Historical Studies of Medieval Iberia
- Monoclonal and Polyclonal Antibodies Research
- Potassium and Related Disorders
- Ocular Oncology and Treatments
- Birth, Development, and Health
- Vestibular and auditory disorders
- Therapeutic Uses of Natural Elements
- Muscle and Compartmental Disorders
- Plant and soil sciences
- Prenatal Screening and Diagnostics
Hospital Universitario La Paz
2013-2025
Kyung Hee University
2016-2024
Hospital Universitario Virgen de las Nieves
2004-2024
Instituto de Investigación Biosanitaria de Granada
2024
Servicio Cántabro de Salud
2023
Hospital Universitari Germans Trias i Pujol
2023
University of California, San Francisco
2020-2022
Sociedad Española de Cardiología
2019
Keele University
2019
Hospital Universitario Severo Ochoa
2001-2017
Between October 1998 and April 1999, 51 persons belonging to two separate groups developed acute pulmonary histoplasmosis after visiting a cave in Costa Rica. The first group consisted of 61 children 14 adults from San Jose, Rica; 44 (72%) were diagnosed with histoplasmosis. second comprised tourists the United States Canada; 9 (64%) After median incubation time days, most common symptoms headache, fever, cough, myalgias. Risk factors for developing included crawling (odds ratio [OR] = 17.5,...
<i>Background/Aim:</i> Sodium and water retention is common in peritoneal dialysis patients contributes to cardiovascular disease. As sodium removal depends partly on dwell time, automated (APD) often uses short time exchanges, the aim of this study was compare 24-hour APD standard continuous ambulatory (CAPD) analyze its possible influence blood pressure control. <i>Methods:</i> A total 53 balance studies (30 23 CAPD) were performed 36 stable patients. The net...
Vasoactive intestinal peptide (VIP) receptor density is high in the pineal gland, which receives VIP innervation and responds to with a relatively small increase cAMP cGMP levels. In present study, we show that (5-200 nM) treatment increased intracellular calcium concentration ([Ca2+]i) 64% of isolated individual pinealocytes; comparison, norepinephrine (NE) elevated [Ca2+]i 93% cells produced more robust responses. Analysis role second messengers indicated was strongly by analogs, but not...
Pancreatic islets (PIs) are damaged under diabetic conditions, resulting in decreased PI size. This study examined the regenerative effects of coffee and its components (caffeine, CFI; trigonelline, TRG; chlorogenic acid, CGA) on zebrafish larval PIs β-cells by administration alloxan (AX). In addition, influence active KATP channels was investigated using diazoxide (DZ) as a channel activator. size fluorescence intensity were significantly increased coffee-treated group relative to...
Ginger (Zingiber officinale Roscoe) and its active compounds (gingerols, shogaols paradols) have been reported as having beneficial functions for several diseases, including diabetes. In this study, we revealed that the steaming process could enhance anti-diabetic potential of ginger. To confirm effect steamed ginger extract (GG03), assessed pancreatic islets impaired by alloxan in zebrafish demonstrated anti-hyperglycemic efficacy a mouse model. The EC50 values (GE) GG03 showed was greater...
Testosterone deficiency (hypogonadism) is common among men undergoing haemodialysis, but its clinical implications are not well characterized. an anabolic hormone that induces erythrocytosis and muscle synthesis. We hypothesized testosterone would be associated with low mass, physical inactivity higher dosages of erythropoietin-stimulating agents (ESA). Single-center cross-sectional study 57 male haemodialysis patients. None the patients was replacement therapy. Total measured in serum. Body...
Sensorineural hearing loss (SNHL) is one of the most common causes disability, affecting over 466 million people worldwide. However, prevention or therapy SNHL has not been widely studied. Avocado oil shown many health benefits but it yet studied in regards to SNHL. Therefore, we aimed investigate efficacy avocado on vitro and vivo elucidate its mode action. For present study, used enhanced functional extract (DKB122). DKB122 led recovery otic hair cells zebrafish after neomycin-induced cell...
Historical and recent data demonstrate that off-the-shelf infant formulas are heavily contaminated with aluminium. The origin of this contamination remains to be elucidated though may imported via ingredients, packaging processing. Specialised exist address health issues, such as low birth weight, allergy or intolerance medical conditions, renal insufficiency. aluminium content these prescription is measured here for the first time. We obtained 24 through a paediatric clinic their total by...
Persea americana Mill., Lauraceae, commonly known as the avocado, is native to tropical and subtropical regions, including Brazil. From leaves of P. americana, one previously undescribed flavonol glycoside (1) together with ten flavonoids (2–11), four megastigmane glycosides (12–15) two lignans (16–17) were isolated. Their structures determined by extensive spectroscopic methods 1D- 2D-nuclear magnetic resonance mass spectrometry data. This first investigation that reports lignan classes...
Background . Low serum magnesium has been associated with an increased cardiovascular risk in the general population and dialysis patients. Our aim was to analyze influence of on overall mortality outcomes patients advanced CKD not yet dialysis. Methods Seventy stages 4 5 were included. After a single measurement s-magnesium, followed mean 11 months. Primary end-point death any cause, secondary occurrence fatal or nonfatal CV events. Results Basal s-magnesium within normal range (<mml:math...
20(S)-Protopanaxadiol 20-O-D-glucopyranoside, also called compound K (CK), exerts antidiabetic effects that are mediated by insulin secretion through adenosine triphosphate (ATP)-sensitive potassium (KATP) channels in pancreatic β-cells. However, the of CK may be limited because its low bioavailability.In this study, we aimed to enhance activity and lower toxicity including it with β-cyclodextrin (CD) (CD-CK), determine whether CD-CK enhanced islet recovery, compared alone, an...
Background . We examine whether cystatin C, a surrogate marker of renal function, could identify patients with chronic kidney disease (CKD) an increased risk progression, death, or cardiovascular events. Methods Data were obtained for 180 patients, diagnosis failure based on serum creatinine estimated glomerular filtration rate (eGFR creat ) <90 mL/min/1.73 m 2 This population was grouped in tertiles according to C and values at baseline. Cardiovascular events overall mortality each...
Background. Predicting the progression of kidney failure in patients with chronic disease is difficult. The aim this study was to assess predictors rapid decline a cohort referred single outpatient nephrology clinic. Design. Longitudinal, prospective median follow-up 3.39 years. Methods. Data were obtained from 306 renal based on serum creatinine-estimated glomerular filtration rate (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:msub><mml:mrow><mml:mi...
Changing consumption patterns and increasing health awareness, especially in Europe, are resulting an increased demand for sesame seeds. In 2016, Asia imported the highest quantity of seeds, followed by Europe North America. We examined, first time, effects treatment with oil sesamin hearing impairment models. Sesame exhibited ameliorative effect on auditory a hair cell line zebrafish mice. ototoxic larvae, neuromasts otic cells numbers because oil. Furthermore, function noise-induced loss...
Repeated column separation yielded four enterolactone type lignans from Forsythia koreana flowers (FKF), whose chemical structures were identified using several spectral technics. FKF MeOH extract (FKFM) and significantly recovered aloxan induced pancreatic islet in zebrafish. Especially, aglycones, 1 3, exhibited relatively higher activity than the lignan glycosides, 2 4. Therefore, FKFM was fermented a Microbacterium esteraromaticum, BGP1, to yield (FKFM-BGP1). FKFM-BGP1 extracted...
The electronic prescription refill rate (EPRR) of 183 consecutive patients was determined over a 19-month retrospective study period, divided into 7 months PRE (Sep-19 to Mar-20) and 12 POST pandemic (Apr-20 Mar-21), in order compare adherence inhaled corticosteroids (ICS) with asthma prior during the COVID-19 pandemic. Before (PRE), an average 0.58 inhalers/month were from pharmacy; [SD 0.33], very similar 0.59 inhalers/month; 0.34] retrieved subsequent since (POST) (p = 0.768). EPRR showed...
Diabetic sensorineural damage is a complication of the sensory neural system, resulting from long-term hyperglycemia. Red ginseng (RG) has shown efficacy for treatment various diseases, including diabetes mellitus; however, there little research about its benefit treating damage. Therefore, we aim to evaluate RG in alloxan-induced diabetic neuromast (AIDN) zebrafish.In this study, developed and validated an AIDN zebrafish model. To assess effectiveness, observed morphological changes live...
Avocado oil is beneficial to human health and has been reported have effects on sensorineural hearing loss (SNHL). However, the compounds in avocado that affect SNHL not identified. In this study, we identified 20 from oil, including two new 18 known fatty acid derivatives, using extensive spectroscopic analysis. The efficacy of isolated for improving was investigated an ototoxic zebrafish model. compounds, namely (2R,4R,6Z)-1,2,4-trihydroxynonadec-6-ene...