A5019687552- Neuroscience and Neuropharmacology Research
- Alzheimer's disease research and treatments
- Memory and Neural Mechanisms
- Neural dynamics and brain function
- Neuroscience and Neural Engineering
- Data Quality and Management
- Privacy-Preserving Technologies in Data
- Alkaloids: synthesis and pharmacology
- Photoreceptor and optogenetics research
- Neuroinflammation and Neurodegeneration Mechanisms
- Biological and pharmacological studies of plants
- Cryptography and Data Security
- Sleep and Wakefulness Research
- Blockchain Technology Applications and Security
- Glaucoma and retinal disorders
- Adenosine and Purinergic Signaling
- Genetics and Neurodevelopmental Disorders
- Chemical synthesis and alkaloids
- Advanced Image and Video Retrieval Techniques
- Web Data Mining and Analysis
- Cholinesterase and Neurodegenerative Diseases
- Child Development and Digital Technology
- Epilepsy research and treatment
- Traditional Chinese Medicine Analysis
- Hydrology and Watershed Management Studies
Army Medical University
2010-2024
University of Chicago
2022-2024
China University of Geosciences
2020
Czech Academy of Sciences, Institute of Physiology
2014
Air Force Medical University
2012
Abstract Background The over-activation of adenosine A 2A receptors (A R) is closely implicated in cognitive impairments Alzheimer's disease (AD). Growing evidence shows that R blockade possesses neuroprotective effects on AD. Spatial navigation impairment an early manifestation deficits However, whether can prevent spatial function and the underlying mechanism still unclear. Methods transgenic APP/PS1 mouse model AD amyloidosis was used this study. Behavioral tests were conducted to observe...
Accumulated soluble amyloid beta- (A β -) induced aberrant neuronal network activity may directly contribute to cognitive deficits, which are the most outstanding characteristics of Alzheimer’s disease (AD). The entorhinal cortex (EC) is one earliest affected brain regions in AD. Impairments EC neurons responsible for deficits However, little effort has been made investigate effects A on discharge properties vivo . present study was designed examine 1−42 neurons, using extracellular single...
Recent experimental and theoretical data indicate that the functional capabilities of axons with specialized structures are much more diverse than traditionally thought. However, few observations were concerned main without arborization. In present study, electrical stimulation saphenous nerve at different frequencies (2, 5, 10, 20 Hz) was used to test role activity-dependent effects on pattern action potentials propagate along individual unmyelinated fibers (C fibers) within trunk in...
Pooling and sharing data increases distributes its value. But since cannot be revoked once shared, scenarios that require controlled release of for regulatory, privacy, legal reasons default to not sharing. Because selectively controlling what is difficult, the few data-sharing consortia exist are often built around agreements resulting from long tedious one-off negotiations. We introduce Data Station, a escrow designed enable formation consortia. owners share with knowing it will released...
Abnormal accumulation of soluble amyloid beta (Aβ) is believed to cause malfunction neurons in Alzheimer's disease (AD). The hippocampus one the earliest affected brain regions AD. However, little effort has been made investigate effects Aβ1–42 oligomers on discharge properties hippocampal vivo. This study was designed examine CA1 using extracellular single-unit recordings protective riluzole (RLZ) were also investigated for prevention Aβ1–42-induced alterations spontaneous neurons. results...
We present Ver <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sup> , a data discovery system that identifies project-join views over large repositories of tables do not contain join path information, and even when input queries are inaccurate. implements reference architecture to solve both the technical (scale search) human (semantic ambiguity, navigating number results) problems view discovery. demonstrate users find they want using with...
Accurate estimations of evapotranspiration (ET) are essential for understanding land-atmosphere coupling and atmosphere-underlying surface energy water vapor exchanges. Based on input data processing, this paper simulates the temporal spatial variation ET in Dajiuhu Basin from 1990 to 2018 using BEPS-TerrainLab V2.0 model. Compared with measured by an eddy covariance (EC) tower, model explained 80.1% variation. From 2018, average annual was 1262.7 mm/yr indicating a downward trend (−27.12...
Electrical stimulation of ventral division medial geniculate body (MGBv) neurons evokes a shift the frequency-tuning curves auditory cortical (AC) toward best frequency (BF) stimulated MGBv (frequency-specific plasticity). The BF is induced by inhibition responses at recorded AC neuron, with coincident facilitation neuron. However, synaptic mechanisms are not yet understood. We hypothesize that activation thalamocortical transmission and receptor function may contribute to...
Usually, the main axon is assumed to faithfully conduct action potentials (APs). Recent data have indicated that neural processing can occur along axonal path. However, patterns and mechanisms of temporal coding are not clear. In present study, single fiber recording was used analyze activity-dependent modulation AP trains in axons C fibers rabbit saphenous nerve. Trains 5 superthreshold electrical pulses at interstimulus intervals 20 or 50 ms were applied nerve trunk for 200 s. The...
We demonstrate Ver¹ [10], a data discovery system that identifies project-join views over large repositories of tables do not contain join path information. Ver solves both the technical (scale and search) human (semantic ambiguity, navigating number results) problems view discovery.
The data-driven economy has created tremendous value in our society. Individuals share their data with platforms exchange for services such as search, social networks, and health recommendations. Platforms use the to provide those create other revenue-generating opportunities, e.g., selling brokers. With ever-expanding comes growing concern about potential misuse. While most give individuals certain control over (i.e., what is being shared), do not know how will be used once shared; they...