A5018670108- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Cardiovascular Health and Disease Prevention
- Glycosylation and Glycoproteins Research
- Pulmonary Hypertension Research and Treatments
- Mitochondrial Function and Pathology
- Galectins and Cancer Biology
- Gastrointestinal disorders and treatments
- Cardiovascular Disease and Adiposity
- Ubiquitin and proteasome pathways
- Cardiac Ischemia and Reperfusion
- Cancer, Hypoxia, and Metabolism
- Chemotherapy-induced organ toxicity mitigation
- Proteoglycans and glycosaminoglycans research
- Functional Brain Connectivity Studies
- Trace Elements in Health
- Silk-based biomaterials and applications
- Retinal and Optic Conditions
- Advanced Photocatalysis Techniques
- Hydrological Forecasting Using AI
- Extracellular vesicles in disease
- Polyomavirus and related diseases
- Parasitic infections in humans and animals
- Ferroptosis and cancer prognosis
- Alzheimer's disease research and treatments
China Institute of Water Resources and Hydropower Research
2025
Ministry of Water Resources of the People's Republic of China
2025
Tianjin People's Hospital
2016-2024
Tianjin Third Central Hospital
2024
Tianjin Medical University
2024
Qingdao National Laboratory for Marine Science and Technology
2024
Fudan University
2024
Ocean University of China
2024
Marine Biomedical Research Institute of Qingdao
2024
Shanghai Institute of Organic Chemistry
2024
Ferroptosis has emerged as a form of programmed cell death and exhibits remarkable promise for anticancer therapy. However, it is challenging to discover ferroptosis inducers with new chemotypes high ferroptosis-inducing potency. Herein, we report series ferrocenyl-appended GPX4 inhibitors rationally designed in "one stone kills two birds" strategy. selectivity assays, inhibitory activity CETSA experiments validated the inhibition novel compounds on GPX4. In particular, ROS-related...
Purpose.: Proangiogenic protein VEGF-A contributes significantly to retinal lesions and neovascularization in diabetic retinopathy (DR). In preclinical DR, hyperglycemia can upregulate cells. The promoter is responsive the transcription factor specificity 1 (Sp1). O-GlcNAc modification driven by glucose concentration has a profound effect on Sp1 activity. This study investigated effects of Sp1-mediated expression endothelium pigment epithelium. Methods.: Hyperglycemia-exposed ARPE-19 (human...
Tongmai Yangxin Pills (TMYXP), a traditional Chinese patent medicine, has been widely used to treat coronary heart disease for few decades. However, the potential protective effect of TMYXP on cisplatin-induced cardiotoxicity not reported.The target proteins corresponding compounds from Pharmmapper database, PubMed database and ChEMBL were collected construct 'TMYXP-compound-target' network. DAVID was annotation enrichment pathways String 9.1 analysis protein-protein interaction....
ABSTRACT Flood forecasting plays an important role in water resources management and flood prevention, leading to enormous research interests. Given the considerable data amount computational complexity, many scholars have considered this problem from perspective of time-series made substantial contributions a data-driven manner. Based on this, novel method is proposed handle study, which modified denoising diffusion probabilistic model (DDPM). In addition, attention mechanism, Graph...
Metabolic remodeling plays a vital role in the development of heart failure. The trimetazidine can optimize fatty acid and glucose oxidation via inhibition long-chain 3-ketoacyl CoA thiolase heart. So, commonly used cardiovascular therapy as myocardial metabolic drug. This study was conducted to assess effects mechanisms on ketone body metabolism failure rats.A rat model established by continuous subcutaneous injection isoproterenol 10 mg/kg/d. We examined weight, weight index, tested B-type...
Abstract Background The triglyceride glucose-body mass index (TyG-BMI index) has been suggested as a novel predictor of insulin resistance. However, its predictive value for slow coronary flow phenomenon (SCFP) in patients with ischemia and nonobstructive arteries (INOCA) remains unclear. Methods We consecutively recruited 1625 INOCA from February 2019 to 2023 divided them into two groups based on thrombolysis myocardial infarction (TIMI) frame counts (TFCs): the SCFP group ( n = 79) control...
Mitochondrial biosynthesis regulated by the PGC-1α-NRF1-TFAM pathway is considered a novel potential therapeutic target to treat heart failure (HF). Perindopril (PER) an angiotensin-converting enzyme inhibitor that has proven efficacy in prevention of HF; however, its mechanism not well established. In this study, investigate mechanisms PER cardiac protection, rat model cardiomyopathy was established continuous isoproterenol (ISO) stimulation. Changes body weight, weight index,...
A reversed phase (RP)-HPLC method was established for simultaneous determination of chlorogenic acid, arctiin and forsythin in Yinqiao Jiedu Granules, which a commonly used Chinese herbal medical preparation treatment rheum ailments. The based on gradient elution (A: 1% acetic pH=3.0, B: methanol) C18 column an automatic wavelength switching program, where 325 nm acid 280 forsythin, respectively. Good linearities were obtained over the range 2—200 mg·l−1 3 objective compounds. spike...
The aim of the present study was to investigate incremental value resting three-dimensional speckle-tracking echocardiography (3D-STE) in detection early-stage left ventricular dysfunction patients with coronary artery disease (CAD). A total 110 suspected having CAD were recruited. All underwent 3D-STE and angiography (CAG). They divided a group normal according results CAG. Using software, peak values longitudinal strain (LS), circumferential (CS), radial (RS) area (AS) time these strains...
Precise control of selectivity in nitrobenzene hydrogenation is a long-standing challenge, especially under solvent-free conditions. The PdOx the key species for enhancing H2 dissociation and conversion. Here, we report that tuning proportion deposited on CeO2 with regulating methods different preparation methods, shape-selectivity modifying Pd particle sizes could effectively tailor hydrogenation. With calcination temperature 450 °C, Pd/CeO2–4.72 nm catalyst exhibited satisfying...
Pulmonary hypertension (PH) is a frequent complication in patients with pulmonary fibrosis (PF), whereas the mechanism was not well-understood. This study aimed to explore influence of immune cell infiltration on PH status based genomic expression profiles. Microarray data GSE24988 were downloaded from GEO database, including 116 lung tissue samples derived PF various status. Proportion infiltrated cells evaluated using CIBERSORT, gene expression-based de-convolution algorithm. A random...
Abstract Purpose The present study aimed to investigate the cardioprotective potential of soluble guanylate cyclase (sGC) and its 1 subunit on myocardial ischemia/reperfusion injury (MIRI), as well mechanism. Methods SD rats were subjected left coronary artery ischemia/reperfusion, H9C2 cells cultured in an Anaero Pack anaerobic bag induce a MIRI model. Myocardial infarction area, tissue morphology ultrastructure observed by TTC, HE transmission electron microscopy, respectively. tissues...
A 73-year-old man with a 25-year history of liver cirrhosis has been treated for cancer 13 years. His is currently well-controlled, and his AFP normal. The gastroscopy revealed clearly-border whitish mucosa frost-like coating in the greater curvature gastric body. Under magnification, lesion that micro-structure(MS) mucosal surface are faintly discernible, marginal crypt epithelium(MCE) showing irregular closely spaced villous projections. color tone IIb region appears same surrounding...
Abstract OBJECTIVE To explore the diagnostic and predictive value of pulse pressure index (PPI) brachial–ankle wave velocity (baPWV) for coronary heart disease (CHD) in elderly patients with hypertension. METHODS A total 307 who had chest pain or distress angiography were enrolled. According to Gensini score, CHD (n = 260) divided into low-risk group (<20 points, n 96), moderate-risk (20–40 80), high-risk (>40 84). baPWV was measured using an ankle–brachial measuring device....