Proteolysis targeting chimera (PROTAC) is emerging as a promising medicinal modality, which has aroused widespread interest among the field of pharmaceutical manufacturing in recent years. ARV-471 an orally active PROTAC estrogen receptor degrader against breast cancer, leads to ubiquitylation and subsequent degradation receptors via proteasome. In this study, we developed highly sensitive liquid chromatography tandem mass spectrometry method (LLOQ = 0.5 ng/mL) for measurement rat plasma....

Objective: The air content within the lungs directly influences dielectric properties of lung tissue; however, existing studies have been conducted under ex vivo conditions and without quantitatively controlling volume. study aims to develop an improved model using in measurements accurately characterize rabbit tissue across various tidal volumes, based on Kramers-Kronig (KK) relationships. Methods: In this study, six sets different volumes (30, 40, 50, 60, 70, 80 mL) were set frequency band...

Introduction Electrical impedance tomography (EIT) enables non-invasive, continuous, bedside evaluation of ventilation/perfusion (V/Q) match. To avoid the presence invasive monitoring for cardiac output in relative V/Q ratio calculation, we proposed a novel calibration method based on arterial blood pressure to optimize EIT match assessments. Methods We involved 12 mechanically ventilated piglets three experimental phases: baseline, pulmonary embolism, and atelectasis. After thorough...

When using the traditional Douglas–Peucker (D–P) algorithm to simplify linear objects, it is easy generate results containing self-intersecting errors, thus affecting application of D–P algorithm. To solve problem self-intersection, a new vector line simplification based on algorithm, monotonic chains and dichotomy, proposed in this paper. First, used original lines, then simplified lines are divided into several chains. Second, dichotomy search intersection positions effectively,...

Objective: Magnetic induction tomography (MIT) is viewed as a promising method for brain imaging. Most MIT studies are based on time-difference imaging, which cannot be used detecting hemorrhagic stroke. However, many years, multifrequency (mfMIT) has been proposed the early detection of stroke, but focus primarily theoretical analysis and simulations. mfMIT not applied in clinical research owing to issues such inadequate imaging algorithms systems. Methods: A weighted frequency difference...

Electrical impedance tomography (EIT) is a noninvasive and radiation-free imaging method. As "soft-field" technique, in EIT, the target signal center of measured field frequently swamped by at edge, which restricts its further application. To alleviate this problem, study presents an enhanced encoder-decoder (EED) method with atrous spatial pyramid pooling (ASPP) module. The proposed enhances ability to detect central weak targets constructing ASPP module that integrates multiscale...

High structural quality, compressively strained Ge surface epilayers have been grown on Si(100) substrates of up to 200 mm diameter. The epitaxial growth by industrially compatible reduced pressure chemical vapor deposition proceeded uninterruptedly via an intermediate relaxed buffer. In-depth characterization the revealed a relatively smooth and low threading dislocation density. layers were demonstrated remain fully for thicknesses more than 100 nm. high quality material flexibility choose...

Electrical impedance tomography (EIT) is a promising medical technique for monitoring brain injury through the reflection of electrical changes in internal tissues. However, contact impedances at electrode-scalp interfaces can still notably affect EIT accuracy. Hence, we propose method real-time multi-channel cerebral using reference electrode attached close to head vertex. This allows approximate inter-channel differences and over time impedances. The experimental results on 36 volunteers...

Abstract Objective : This study investigated the feasibility of electrical impedance tomography (EIT) for monitoring deterioration ischemic lesion after onset stroke. Approach Fifteen rats were randomly distributed into two groups: operated to establish a right middle cerebral artery occlusion (MCAO) ( n = 10), and sham-operated 5). Then, kept 2 h under anesthesia EIT monitoring. Subsequently, descriptive statistical analysis was performed on whole-brain resistivity changes,...

Objective. Traditional magnetic induction tomography (MIT) algorithms have problems in reconstruction, such as large area error (AE), blurred boundaries of reconstructed targets, and considerable image noise (IN). As the size boundary a lesion greatly affect treatment plan, more accurate are necessary to meet clinical needs.Approach. In this study, adaptive threshold split Bregman (ATSB) is proposed for brain injury monitoring imaging MIT. We established 3D MIT simulation model with actual...

Electrical impedance tomography (EIT) is low-cost and noninvasive has the potential for real-time imaging bedside monitoring of brain injury. However, injury by EIT suffers from image noise (IN) resolution problems, causing blurred reconstructions. To address these a least absolute shrinkage selection operator model built, fast iterative shrinkage-thresholding algorithm with continuation (FISTA-C) proposed. Results numerical simulations head phantom experiments indicate that FISTA-C reduces...

Multi-frequency electrical impedance tomography (mfEIT) offers a nondestructive imaging technology that reconstructs the distribution of characteristics within subject based on spectral differences among biological tissues. However, faces challenges in multi-class lesion targets when conductivity background tissues is frequency-dependent. To address these issues, we propose spatial-frequency cross-fusion network (SFCF-Net) algorithm, built multi-path fusion structure. This algorithm uses...

A cerebral contrast-enhanced electrical impedance tomography perfusion method is developed for acute ischemic stroke during intravenous thrombolytic therapy. Several clinical contrast agents with stable characteristics and high-conductivity were screened experimentally as agent candidates. The was tested on rabbits focal infarction, its capability early detection verified based images. experimental results showed that ioversol 350 performed significantly better an than other (p < 0.01)....

A strain-symmetrized Ge/Si 0.35 Ge 0.65 multiple quantum well (MQW) structure has been grown on a relaxed Si 0.2 0.8 virtual substrate by reduced pressure chemical vapour deposition. The as-grown MQW with one period thickness of 25 nm (14 nm/11 nm) was annealed in nitrogen ambient at different temperatures from 550 to 750 °C. thermal stability and interdiffusion properties were studied high-resolution x-ray diffraction. No obvious or strain relaxation the observed for annealing ⩽600 °C,...

Electrical impedance tomography (EIT) has been shown to be a promising, bedside imaging method monitor the progression of intracranial hemorrhage (ICH). However, observed changes within brain related ICH differed among groups, and we hypothesized that cranium intactness (open or closed) may one potential reasons leading difference. Therefore, aim this study was investigate effect open closed on in rabbit model. In study, first established model 12 rabbits with cranium. Simultaneously, EIT...

The thermal stability of thin (≤110 nm) compressively strained Ge surface channels, grown by reduced-pressure chemical vapor deposition on high quality relaxed Si0.2Ge0.8 reverse-graded buffers, has been investigated using in-situ hydrogen annealing at temperatures up to 650°C. Strain relaxation was observed and found increase for thicker channels higher anneal temperatures. For a channel thickness ≤45 nm, an increased roughening dominate the strain process, which culminated in islanding....

Strain-symmetrized Ge/SiGe multiple quantum wells have been grown on a thin (2.1 µm) relaxed Si 0.2 Ge 0.8 /Ge/Si(1 0 0) virtual substrate (VS) by reduced pressure chemical vapour deposition. Such structures are of interest in optoelectronic applications for which the structural integrity well layers, after processing, is critical. The layer composition, thickness and interface quality studied wafers both as-grown annealing between 550 700 °C. Transmission electron microscopy indicated...

Electrical impedance tomography (EIT) is a noninvasive functional diagnostic technique that has been successfully applied to human lung and brain. EIT reconstruction an ill-conditioned problem: the regularization parameters establish trade-off between acceptable data fitting solution stability. This necessary select optimal for each frame continuously obtain high-quality images in real-time monitoring. However, using objective parameter selection method before image may reduce efficiency,...

Head movement interferences are a common problem during prolonged dynamic brain electrical impedance tomography (EIT) clinical monitoring. mainly originate from body movements of patients and nursing procedures performed by medical staff, etc. These will lead to variation in boundary voltage signals, which affects image reconstruction. This study employed data preprocessing method based on wavelet decomposition inhibit head EIT data. Mixed Gaussian models were applied describe the...

The RCA-cleaned 6H-SiC surface has a 1 nm native oxide layer, which was directly observed by high-resolution transmission electron microscopy and confirmed energy-dispersive X-ray spectroscopy photoelectron spectroscopy. band bending caused the layer studied synchrotron radiation binding energy of Si 2p core level for Ni/oxygen-free SiC interface showed almost zero shift (<0.07 eV). However, it red-shifted about 0.34 eV Ni/native-oxide/SiC interface, indicated that negative charged states...

Detail dynamic characteristics analysis of buck-type PET under general load condition was accomplished and the study showed that: inductive condition, open-loop system is marginally stable serious output voltage oscillation can be provoked by any random disturbance upon input voltage, control signal or current. Therefore, in order to ensure out power quality, we must find a suitable close-loop regulator. In this paper, employed classical PID algorithm instantaneously following pre-setting...

Electrode detachment may occur during dynamic brain electrical impedance tomography (EIT) measurements. After the faulty electrodes have been reset, EIT can restore to steady monitoring but corrupted data, which will challenge interpretation of results, are notoriously difficult recover.Here, a piecewise processing method (PPM) is introduced manage erroneous data after reattachment electrodes. In PPM, we define three phases before, and reconnection electrode as PI, PII PIII, respectively....