Haoran Gao

ORCID: 0000-0003-4480-7263
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About
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Research Areas
  • Food Allergy and Anaphylaxis Research
  • Spine and Intervertebral Disc Pathology
  • Allergic Rhinitis and Sensitization
  • Contact Dermatitis and Allergies
  • Musculoskeletal pain and rehabilitation
  • Spinal Fractures and Fixation Techniques
  • Spinal Hematomas and Complications
  • Cervical and Thoracic Myelopathy
  • Medical Imaging and Analysis
  • Celiac Disease Research and Management
  • Pregnancy-related medical research
  • Regional Development and Environment
  • Asthma and respiratory diseases
  • Pancreatic and Hepatic Oncology Research
  • Rangeland Management and Livestock Ecology
  • Geomechanics and Mining Engineering
  • Cancer, Hypoxia, and Metabolism
  • Heme Oxygenase-1 and Carbon Monoxide
  • Occupational exposure and asthma
  • Environmental and Social Impact Assessments
  • Heavy metals in environment
  • Anesthesia and Pain Management
  • Geochemistry and Geologic Mapping
  • Anesthesia and Neurotoxicity Research
  • Transgenic Plants and Applications

Indiana University School of Medicine
2024-2025

Indiana University – Purdue University Indianapolis
2024-2025

Center for Excellence in Molecular Cell Science
2024

University of Chinese Academy of Sciences
2024

Michigan State University
2018-2024

China University of Geosciences
2023-2024

Air Force Medical University
2009-2024

Xuzhou Medical College
2024

First Affiliated Hospital of Zhengzhou University
2023-2024

Affiliated Hospital of Xuzhou Medical College
2024

Diabetes Mellitus (DM) is widely acknowledged to increase the risk of cardiovascular death, which warrants use aggressive primary prevention strategies. The aim present study was investigate pretreatment effects tanshinone IIA (TSN), a traditional Chinese medicine, on myocardial infarct size, apoptosis, inflammation and cardiac functional recovery in diabetic rats subjected ischaemia/reperfusion (I/R).Streptozocin (STZ) induced (n = 80) were randomized receive TSN, TSN plus wortmannin [a...

10.1111/j.1463-1326.2009.01166.x article EN Diabetes Obesity and Metabolism 2009-11-06

Minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) is an effective surgical option for spinal stenosis (LSS) with spondylolisthesis. However, few studies have discussed oblique lateral (OLIF) MIS-TLIF.To evaluate postoperative improvements, complications, and reoperation rates between patients LSS undergoing OLIF or MIS-TLIF.We retrospectively studied 113 LLS who underwent (53) MIS-TLIF (60) percutaneous pedicle screw fixation January 2016 December 2018. We measured...

10.3389/fmed.2022.829426 article EN cc-by Frontiers in Medicine 2022-05-19

Abstract Food allergy has had a rapid rise in prevalence, and thus it is important to identify approaches limit the development of food early life. Because maternal dietary supplementation with α-tocopherol (α-T), an isoform vitamin E, during pregnancy nursing increases neonate plasma levels α-T can other allergies, we hypothesized that allergy. To assess this, male mice mutations their skin barrier genes (FT−/− mice) were mated wild-type females received diet supplemented or control diet....

10.1093/jimmun/vkae041 article EN other-oa The Journal of Immunology 2025-02-01

Food allergy can be life threatening and often develops early in life, especially infants children with atopic dermatitis. is induced neonatal mice skin barrier mutations (Flaky Tail, FT+/- filaggrin mattrin gene mutations) by epicutaneous sensitization co-exposures to the food allergen peanut extract (PNE), environmental Alternaria alternata (Alt), detergent (4% SDS); oral PNE-challenge induces anaphylaxis. Sensitization these neonates also eosinophil infiltration into elevates expression...

10.1093/jimmun/vkae044 article EN other-oa The Journal of Immunology 2025-03-06

Abstract Minimally invasive surgery (MIS) has shown satisfactory surgical results for the treatment of thoracic myelopathy (TM) caused by ossification ligamentum flavum (OLF). This study investigated prognostic factors following MIS and was based on retrospective analysis OLF patients who underwent percutaneous full endoscopic posterior decompression (PEPD). Thirty single-segment with an average age 60.4 years were treated PEPD under local anaesthesia. Clinical data collected from medical...

10.1038/s41598-020-58198-x article EN cc-by Scientific Reports 2020-01-28

Zucchini (Cucurbita pepo L.) is one of the main vegetable crops grown under protected cultivation in northern China. Low-temperature (LT) stress severely inhibits growth zucchini seedlings, resulting reductions yield and quality. Here, using three kinds different humic acids, including coal-based acid (CHA), fulvic (FA), biochemical (BHA), we investigated effects acids against LT (5 °C) seedlings. Treatment with all improves tolerance by decreasing oxidative damage through increases...

10.3390/plants12030548 article EN cc-by Plants 2023-01-25

Gluten hypersensitivity is characterized by the production of IgE antibodies against specific wheat proteins (allergens) and a myriad clinical allergic symptoms including life-threatening anaphylaxis. Currently, only recommended treatment for gluten complete avoidance gluten. There have been extensive efforts to develop dietary-based novel therapeutics combating this disorder. were four objectives study: (i) compile current understanding mechanism hypersensitivity; (ii) critically evaluate...

10.3390/ijms25084399 article EN International Journal of Molecular Sciences 2024-04-16

Abstract Wheat allergy is a potentiallylife‐threatening disease that affects millions of people around the world. Food processing has been shown to influence allergenicity wheat and other major foods. However, comprehensive review evaluating whether or not food can be used develop hypo‐/nonallergenic products unavailable. There were three objectives for this study: (1) critically evaluate evidence on effect fermentation, thermal processing, enzyme acid hydrolysis so as identify potential...

10.1111/1541-4337.12830 article EN Comprehensive Reviews in Food Science and Food Safety 2021-08-29

Abstract Background Lumbar revision surgery can be performed by simple lumbar nerve decompression or interbody fusion, including percutaneous endoscopic discectomy, transforaminal fusion (TLIF), etc. However, is very difficult in surgical operation. We sought to explore the technique safety and efficacy of microscope-assisted minimally invasive (MI-TLIF) surgery. Methods Cases postoperative recurrence following spine ( n = 63) treated from December 2016 July 2021 were retrospectively...

10.1186/s13018-024-04591-5 article EN cc-by Journal of Orthopaedic Surgery and Research 2024-01-31

Sphingosine 1-phosphate receptor 3 (S1PR3) participates in the inflammatory response multiple types of diseases. However, biological role S1PR3 intervertebral disc degeneration and underlying mechanism are unclear. The aim present study was to investigate functional lipopolysaccharide (LPS)-induced human nucleus pulposus cells. expression Toll-like (TLR) 2 LPS-induced (NP) cells investigated using western blotting. Cell Counting Kit-8 assay used detect cell proliferation, levels factors were...

10.3892/etm.2024.12553 article EN Experimental and Therapeutic Medicine 2024-04-25

Objective The main aim of this study was to investigate the ovarian reserve, menstruation, and lymphocyte subpopulation in systemic lupus erythematosus (SLE) patients childbearing age. Methods We enrolled 40 SLE age age-matched healthy controls. Anti-Müllerian hormone (AMH) tested by electrochemiluminescence, subsets were flow cytometry. Menstruation situation obtained interview. Results AMH level group significantly lower than that control ( p < 0.001), which negatively correlated with...

10.1177/0961203317726378 article EN Lupus 2017-08-18

Recent studies have investigated the separation of olefins from fluid catalytic cracking naphtha by solvent treatment to produce motor gasoline. This study explored effect structure and group six solvents on 1-hexene–benzene 1-hexene–thiophene systems. Solvents with a chain structure, such as N-methyl diethanolamine (MDEA) tetraethylene glycol, showed satisfactory performance for but poor benzene thiophene. result can be ascribed weak polarity low solubility By contrast, ring separated...

10.1021/acs.energyfuels.9b00939 article EN Energy & Fuels 2019-05-13

Wheat allergy and other immune-mediated disorders triggered by wheat proteins are growing at an alarming rate for reasons not well understood. A mouse model to study hypersensitivity responses salt-soluble protein (SSWP) extract is currently unavailable. Here we tested the hypothesis that SSWP from will induce sensitization as allergic disease in mice.Female BALB/cJ mice were weaned onto a plant protein-free diet. The injected total of 4 times with (0.01 mg/mouse) fraction extracted durum...

10.1159/000479386 article EN International Archives of Allergy and Immunology 2017-01-01

There are many pharmaceutical interventions available to prevent osteoporotic vertebral fractures in postmenopausal women, but the efficacy and safety of these drugs unknown. This study aimed investigate prevention fractures.PubMed, Embase, Cochrane Library were comprehensively searched for randomized controlled trials (RCTs) published up February 15, 2020, including women with osteoporosis. Network meta-analysis was conducted based on Handbook Systematic Reviews Interventions Preferred...

10.1016/j.heliyon.2022.e11880 article EN cc-by-nc-nd Heliyon 2022-11-29
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